Remodeling of uterine innervation.
Abstract
This minireview reports current hypotheses concerning the remodeling of sympathetic innervation in rodent and human uterus during the estrous cycle and gestation. Neural modulation in this organ is related to sexual hormone concentrations, and a reduction in nerve density is observed when estrogen levels are high during the estrous cycle. Estrogen receptor alpha is considered to be the major receptor mediating the action of estrogen. In the uterus, the expression of neurotrophins, such as nerve growth factor, which are involved in the survival and growth of nerve fibers, changes in response to steroid levels. Despite much research, further studies are necessary to clarify various aspects of nerve growth control under diverse physiological conditions. These studies could be of importance, since alterations of the biological mechanisms of uterus innervation may play significant roles in various pathologies, such as infertility and spontaneous abortion.
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Innervation of the healthy uterus undergoes anatomical changes during the ovarian cycle and significant changes during pregnancy.
“Furthermore, others have shown in both rodents and humans that innervation of the healthy uterus also undergoes anatomical changes during the ovarian cycle as well as significant changes during pregnancy [42].”
From Sprouted Innervation into Uterine Transplants Contributes to the Development of Hyperalgesia in a Rat Model of Endometriosis (2012) · cites this paper as [42]
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- Authors
- Latini, C., Frontini, A., Morroni, M., Marzioni, D., Castellucci, M., & Smith, P. G.
- Affiliations
- Marche Polytechnic University (IT)
- University of Kansas Medical Center (US)
- Corresponding author
- Castellucci, M.
- Venue
- Cell and Tissue Research
- Published
- 2008-08-02
- Volume
- 334
- Issue
- 1
- Pages
- 1-6
- ISSN
- 0302-766X (ISSN-L)
- 1432-0878
- OpenAlex
- W2061718936
- Cited by
- 43
- References
- 53
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 2 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 5 · 2013: 5 · 2012: 9
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell and Tissue Research (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- uterine innervation, sympathetic innervation, estrous cycle, pregnancy, estrogen, estrogen receptor alpha, nerve growth factor, neurotrophins, nerve fiber density, infertility, miscarriage
- MeSH terms
- Animals, Estrogens, Estrus, Female, Humans, Receptors, Estrogen, Uterus, Receptor, Nerve Growth Factor, Receptor, trkA, Nerve Growth Factor, Estrous Cycle, Mice, Neurogenesis
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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