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Autophagy and apoptosis interplay during follicular atresia in fish ovary: a morphological and immunocytochemical study

Morais, R. D. V. S., Thomé, R. G., Lemos, F. S., Bazzoli, N., Rizzo, E.·2012·Cell and Tissue Research
DOI 10.1007/s00441-012-1327-6
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Abstract

Follicular atresia in fish ovary provides an interesting model for studying autophagy and apoptosis. In order to improve knowledge of the mechanisms regulating ovarian regression, we investigated the immunolocalisation of various proteins involved in the complex network of autophagy and apoptosis. Females of three species of freshwater fish maintained in captivity were sampled after the reproductive period and the main events of follicular atresia were assessed by histology: splits in the zona radiata, yolk degradation and reabsorption, hypertrophy of the follicular cells, accumulation of autophagic vacuoles, closing of the follicular lumen and thickening of the theca. The interplay of apoptosis and autophagy was analysed by TUNEL in situ and by immunocytochemistry for caspase-3, bax, bcl-2, beclin-1 and cathepsin-D. During early and advanced stages of follicular regression, the actin cytoskeleton was well developed and labelling for bcl-2 and cathepsin-D were pronounced in the follicular cells at a stage when they were intensively involved in yolk phagocytosis. Immunofluorescence for beclin-1 was prevalent in the follicular cells, punctate labelling often surrounding autophagic vacuoles during the advanced stage of follicular regression, a critical step towards cell death. TUNEL-positive reaction and immunostaining for bax and caspase-3 demonstrated the participation of apoptosis in late follicular regression. Overall, this study provides evidence that autophagic and apoptot…

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Metadata

Authors
Morais, R. D. V. S., Thomé, R. G., Lemos, F. S., Bazzoli, N., & Rizzo, E.
Venue
Cell and Tissue Research
Publisher
Springer Science and Business Media LLC
Published
2012-02
Volume
347
Issue
2
Pages
467-478
ISSN
  • 0302-766X
  • 1432-0878
DOI
10.1007/s00441-012-1327-6
Cited by
69
References
2
Language
en
Licence
www.springer.com/tdm (tdm)

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