Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
Open accessAbstract
Autophagic and endocytic pathways are tightly regulated membrane rearrangement processes that are crucial for homeostasis, development and disease. Autophagic cargo is delivered from autophagosomes to lysosomes for degradation through a complex process that topologically resembles endosomal maturation. Here, we report that a Beclin1-binding autophagic tumour suppressor, UVRAG, interacts with the class C Vps complex, a key component of the endosomal fusion machinery. This interaction stimulates Rab7 GTPase activity and autophagosome fusion with late endosomes/lysosomes, thereby enhancing delivery and degradation of autophagic cargo. Furthermore, the UVRAG-class-C-Vps complex accelerates endosome-endosome fusion, resulting in rapid degradation of endocytic cargo. Remarkably, autophagosome/endosome maturation mediated by the UVRAG-class-C-Vps complex is genetically separable from UVRAG-Beclin1-mediated autophagosome formation. This result indicates that UVRAG functions as a multivalent trafficking effector that regulates not only two important steps of autophagy - autophagosome formation and maturation - but also endosomal fusion, which concomitantly promotes transport of autophagic and endocytic cargo to the degradative compartments.
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Fusion of autophagosomes with lysosomes is mediated by the HOPS complex, whose subunits include VPS11, VPS16, VPS18, VPS33A, VPS39, and VPS41.
“Fusion of the autophagosome and lysosome is mediated by the homotypic fusion and protein sorting (HOPS) complex, whose subunits include VPS11, VPS16, VPS18, VPS33A, VPS39, and VPS41 [45,46].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [45]
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- Authors
- Liang, C., Lee, J.-S., Inn, K.-S., Gack, M. U., Li, Q., Roberts, E. A., Vergne, I., Deretic, V., Feng, P., Akazawa, C., & Jung, J. U.
- Affiliations
- University of Southern California (US)
- Harvard University (US)
- University of New Mexico (US)
- The University of Texas Southwestern Medical Center (US)
- Tokyo Medical and Dental University (JP)
- Corresponding author
- Jung, Jae U.
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2008-06-15
- Volume
- 10
- Issue
- 7
- Pages
- 776-787
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC2878716
- OpenAlex
- W2155175976
- Cited by
- 792
- References
- 47
- Citations by year
- 2026: 16 · 2025: 30 · 2024: 21 · 2023: 36 · 2022: 37 · 2021: 55 · 2020: 45 · 2019: 51 · 2018: 49 · 2017: 46 · 2016: 46 · 2015: 45 · 2014: 61 · 2013: 55 · 2012: 60
- FWCI
- 34.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL110609)
- National Cancer Institute (CA82057, CA 106156, R01CA091819, CA-31363, R01CA106156, R01CA082057, CA-91819, R01CA031363)
- National Institute of Allergy and Infectious Diseases (AI069345, R01AI073099, AI42999, R01AI042999, R01AI069345, R37AI042999)
- National Center for Research Resources (RR00 168, K26RR000168, P51RR000168)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- UVRAG, Beclin-1, autophagosome maturation, endosomal membrane fusion, autophagosome-lysosome fusion, endosomal trafficking, autophagy, membrane trafficking
- MeSH terms
- Beclin-1, Animals, Autophagy, Cell Line, Endocytosis, Humans, Lysosomes, Membrane Fusion, Membrane Proteins, Phagosomes, Endosomes, Recombinant Fusion Proteins, rab GTP-Binding Proteins, Protein Transport, Tumor Suppressor Proteins, Vesicular Transport Proteins, Multiprotein Complexes, Apoptosis Regulatory Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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