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Neuronal apoptosis at the G1/S cell cycle checkpoint
Abstract
Apoptosis is a fundamental and essential process in development and tissue homeostasis of multicellular organisms. Roughly half of all the neurons produced during neurogenesis die apoptotically before the nervous system matures. Apoptosis is also involved in various neurodegenerative disorders such as Alzheimer's disease and neuronal trauma. Investigation of the mechanisms underlying neuronal apoptosis led to an unexpected discovery that in many cases revival of the quiescent and dormant cell cycle machinery is a common theme. Recent data suggest that uncoordinated expression of cell cycle molecules and the consequent breach of cell cycle checkpoints could be one of the primary mechanisms by which postmitotic neurons undergo apoptotic death. Evidence indicates that upregulation of cyclin-D-CDK4/6 activity and deregulation of E2F transcription factors mark key events in early stages of neuronal apoptosis. Active E2F repression by Rb family members is required for the survival of neurons. Apoptotic signals promote successive phosphorylation and dysfunction of Rb family members, resulting in sequential E2F derepression and expression of selective E2F-responsive genes. Thus, expression of derepressed E2F-responsive genes may be instrumental in propagating and amplifying the apoptotic signals instructing neuronal cells to carry out the apoptotic program.
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“Nevertheless, despite these several defence mechanisms, authors showed a cell cycle regulatory failure in lymphocytes as it was observed in neurons [130–132, 168, 169].”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [130]
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Metadata
- Authors
- Liu, D. X., & Greene, L. A.
- Affiliations
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- Corresponding author
- Liu, David X.
- Venue
- Cell and Tissue Research
- Published
- 2001-05-17
- Volume
- 305
- Issue
- 2
- Pages
- 217-228
- ISSN
- 0302-766X (ISSN-L)
- 1432-0878
- OpenAlex
- W2031825480
- Cited by
- 234
- References
- 1
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 9 · 2015: 8 · 2014: 4 · 2013: 9 · 2012: 7
- FWCI
- 6.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell and Tissue Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- neuronal apoptosis, G1/S cell cycle checkpoint, postmitotic neurons, cyclin D1, CDK4/6, E2F transcription factors, retinoblastoma protein, neurogenesis, neurodegeneration, Alzheimer's disease, cell cycle re-entry
- MeSH terms
- Animals, Cell Cycle, DNA-Binding Proteins, Humans, Neurons, Nuclear Proteins, Phosphoproteins, Proteins, Proto-Oncogene Proteins, Transcription Factors, Signal Transduction, Retinoblastoma Protein, G1 Phase, S Phase, Cyclins, Apoptosis, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Cyclin-Dependent Kinases, E2F Transcription Factors, Retinoblastoma-Like Protein p130, Retinoblastoma-Like Protein p107, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Cyclin D
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