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Ventral hernia repair with poly-4-hydroxybutyrate mesh
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“To date, long-term clinical outcomes associated with P4HB mesh have not been reported beyond these 18–24 month studies, possibly due to the high costs associated with conducting a long-term clinical trial.”
From Prospective, multicenter study of P4HB (Phasix™) mesh for hernia repair in cohort at risk for complications: 3-Year follow-up (2021) · cites this paper as [9]
In the citing paper
“The results of this study compare well with the published literature, including a pilot study involving P4HB mesh in small to medium-sized, routine ventral hernias in which Plymale et al. (21) reported 0.0% SSI, 19.4% SSO (primarily seroma) and 12.9% readmission at a median follow up of 414 days. In a retrospective case review of the National Surgery Quality Improvement (NSQIP) database, Wagner et”
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Research works printed but not linked: 25
- DeBord JR (1998) The historical development of prosthetics in hernia surgery. Surg Clin N Am 78:973–1006. doi:10.1016/S0039-6109(05)70365-0 · DOI
- Sanders D, Kingsnorth AN (2012) From ancient to contemporary times: a concise history of incisional hernia repair. Hernia 16:1–7. doi:10.1007/s10029-011-0870-5 · DOI
- Buinewicz B, Rosen B (2004) Acellular cadaveric dermis (AlloDerm): a new alternative for abdominal hernia repair. Ann Plas Surg 52:188–194 · DOI
- Patton JH, Berry S, Kralovich KA (2007) Use of human acellular dermal matrix in complex and contaminated abdominal wall reconstructions. Am J Surg 193:360–363. doi:10.1016/j.amjsurg.2006.09.021 · DOI
- Luijendijk RW, Hop WCJ, van den Tol MP, de Lange DCD, Braaksma MMJ, IJzermans JNM, Boelhouwer RU, de Vries BC, Salu MKM, Wereldsma JCJ, Bruijninckx C, Jeekel J (2000) A comparison of suture repair with mesh repair for incisional hernia. N Engl J Med 343:392–398. doi:10.1056/NEJM200008103430603 · DOI · Paper page
- Burger JWA, Luijendijk RW, Hop WCJ, Halm JA, Verdaasdonk EGG, Jeekel J (2004) Long-term follow-up of a randomized controlled trial of suture versus mesh repair of incisional hernia. Ann Surg 240:578–585. doi:10.1097/01.sla.0000141193.08524.e7 · DOI · Paper page
- Roth JS, Brathwaite C, Hacker K, Fisher K, King J (2015) Complex ventral hernia repair with a human acellular dermal matrix. Hernia 19:247–252. doi:10.1007/s10029-014-1245-5 · DOI
- Bondre IL, Holihan JL, Askenasy EP, Greenberg JA, Keith JN, Martindale RG, Roth JS, Liang MK (2016) Suture, synthetic, or biologic in contaminated ventral hernia repair. J Surg Res 200:488–494. doi:10.1016/j.jss.2015.09.007 · DOI
- Fayezizadeh M, Majumder A, Belyansky I, Novitsky YW (2016) Outcomes of retromuscular porcine biologic mesh repairs using transversus abdominis release reconstruction. J Am Coll Surg 223:461–468 · DOI
- Majumder A, Winder JS, Wen Y, Pauli E, Belyansky I, Novitsky YW (2016) Comparative analysis of biologic versus synthetic mesh outcomes in contaminated hernia repairs. Surgery 160:828–838 · DOI
- Totten CF, Davenport DL, Ward ND, Roth JS (2016) Cost of ventral hernia repair using biologic or synthetic mesh. J Surg Res 203:459–465. doi:10.1016/j.jss.2016.02.040 · DOI
- Carbonell AM, Criss CN, Cobb WS, Novitsky YW, Rosen MJ (2013) Outcomes of synthetic mesh in contaminated ventral hernia repairs. J Am Coll Surg 217:991–998 · DOI · Paper page
- Cobb WS, Carbonell AM, Kalbaugh CL, Jones Y, Lokey JS (2009) Infection risk of open placement of intraperitoneal composite mesh. Am Surg 75:762–768 · DOI
- Williams SF, Martin DP, Moses AC (2016) The history of GalaFLEX P4HB scaffold. Aesthet Surg J 36:S33–S42. doi:10.1093/asj/sjw141 · DOI · Paper page
- Deeken CR, Matthews BD (2013) Characterization of the mechanical strength, resorption properties, and histologic characteristics of a fully absorbable material (poly-4-hydroxybutyrate—PHASIX Mesh) in a porcine model of hernia repair. ISRN Surg. doi:10.1155/2013/238067 · DOI · Paper page
- Martin DP, Badhwar A, Shah DV, Rizk S, Eldridge SN, Gagne DH, Ganatra A, Darois RE, Williams SF, Tai H-C, Scott JR (2013) Characterization of poly-4-hydroxybutyrate mesh for hernia repair applications. J Surg Res 184:766–773. doi:10.1016/j.jss.2013.03.044 · DOI · Paper page
- Bauer JJ, Harris MT, Gorfine SR, Kreel I (2002) Rives–Stoppa procedure for repair of large incisional hernias: experience with 57 patients. Hernia 6:120–123 · DOI
- Reynolds D, Davenport D, Korosec R, Roth JS (2013) Financial implications of ventral hernia repair: a hospital cost analysis. J Gastroint Surg 17:159–167. doi:10.1007/s11605-012-1999-y · DOI
- Plymale MA, Ragulojan R, Davenport DL, Roth JS (2017) Ventral and incisional hernia: the cost of comorbidities and complications. Surg Endosc 31:341–351. doi:10.1007/s00464-016-4977-8 · DOI
- Holihan JL, Alawadi Z, Martindale RG, Roth JS, Wray CJ, Ko TC, Kao LS, Liang MK (2015) Adverse events after ventral hernia repair: the vicious cycle of complications. J Am Coll Surg 221:478–485 · DOI
- Helgstrand F, Rosenberg J, Kehlet H, Jorgensen LN, Bisgaard T (2013) Nationwide prospective study of outcomes after elective incisional hernia repair. J Am Coll Surg 216:217–228 · DOI · Paper page
- Scott JR, Deeken CR, Martindale RG, Rosen MJ (2016) Evaluation of a fully absorbable poly-4-hydroxybutyrate/absorbable barrier composite mesh in a porcine model of ventral hernia repair. Surg Endosc 30:3691–3701 · DOI
- Tedelin S, Westbert F, Kjerrulf M, Vidal A (2007) Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease. World J Gastroenterol 13:2826–2832 · DOI
- Wang F, Liu J, Wong T, Shen K, Chen Z, Yu Y, Huang Q, Wang G, Jin S (2016) The inflammation induced by lipopolysaccharide can be mitigated by short chain fatty acid, butyrate, through up-regulation of IL-10 in septic shock. Scand J Immunol. doi:10.1111/sji.12515 · DOI
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Cited by
Roth, J. S., Anthone, G. J., Selzer, D. J., Poulose, B. K., Pierce, R. A., Bittner, J. G., Hope, W. W., Dunn, R. M., Martindale, R. G., Goldblatt, M. I., et al. (2021) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2020.12.002 · Cited by 40
Self-citationDeeken, C. R., Rosen, M. J., Poulose, B. K., Bradbury, K., Huang, L.-C., Ma, J., & Badhwar, A. (2023) · Frontiers in Surgery · doi:10.3389/fsurg.2023.1280991 · Cited by 7
Metadata
- Authors
- Plymale, M. A., Davenport, D. L., Dugan, A., Zachem, A., & Roth, J. S.
- Venue
- Surgical Endoscopy
- Published
- 2017-09-15
- Volume
- 32
- Issue
- 4
- Pages
- 1689-1694
- ISSN
- 0930-2794
- 1432-2218
- Cited by
- 43
- References
- 0
- Language
- en
- Funders
- Davol, Inc. (3048110246)
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Cite CoChat for the checks on this page, and the paper for its own findings.
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- CoChat. (2026). Citation check: Ventral hernia repair with poly-4-hydroxybutyrate mesh. https://app.cochat.ai/papers/10.1007/s00464-017-5848-7
- The paper
- Plymale, M. A., Davenport, D. L., Dugan, A., Zachem, A., & Roth, J. S. (2018). Ventral hernia repair with poly-4-hydroxybutyrate mesh. Surgical Endoscopy. https://doi.org/10.1007/s00464-017-5848-7
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
