Carotid intima media thickness, oxidative stress, and inflammation in children with chronic kidney disease
Abstract
Objective We evaluated the association between inflammation and oxidative stress with carotid intima media thickness (cIMT) and elasticity increment module (E(inc)) in pediatric patients with chronic kidney disease (CKD).Methods This analytical, cross-sectional study assessed 134 children aged 6-17 years with CKD. Anthropometric measurements and biochemistry of intact parathyroid hormone (iPTH), high-sensitivity C-reactive protein (CRP), interleukin (IL)-6, IL-1β, reduced glutathione (GSH), malondialdehyde, nitric oxide, and homocysteine were recorded. Bilateral carotid ultrasound (US) was taken. Patients were compared with controls for cIMT and E(inc) using ≥ 75 percentile (PC).Results Mean cIMT was 0.528 ± 0.089 mm; E(inc) was 0.174 ± 0.121 kPa × 10(3); cIMT negatively correlated with phosphorus (r -0.19, p =0.028) and the calcium × phosphorus (Ca × P) product (r -0.26, p =0.002), and positively with iPTH (r 0.19,p =0.024). After adjusting for potential confounders, hemodialysis (HD) (β=0.111, p =<0.001), automated peritoneal dialysis (APD) (β=0.064, p =0.026), and Ca x P product(β=-0.002, p =0.015) predicted cIMT (R(2)=0.296). In patients on dialysis, HD (β=0.068, p =0.010), low-density lipoprotein cholesterol (LDL-C) (β=0.001, p =0.048), and GSH(β=-0.0001, p=0.041) independently predicted cIMT (R(2)=0.204); HD, hypoalbuminemia, and high iPTH increased the risk of increased cIMT. In dialysis, E(inc) was inversely associated with GSH, and in predialysis, Ca × P correlated with/predicted E(inc) (β=0.001, p =0.009).Conclusions cIMT and E(inc) strongly associate with several biochemical parameters and GSH but not with other oxidative stress or inflammation markers.
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Deteriorated renal function correlates with altered markers of oxidative stress including mitochondrial oxidized LDL, homocysteine, and deficiency of reduced glutathione (GSH) and superoxide dismutase (SOD).
“Deteriorated renal function correlates well with the altered markers of oxidative stress. These involve mitochondrial oxidized low-density lipoprotein (Garcia-Bello et al. 2014), homocysteine (Chien et al. 2015), and deficiency of reduced glutathione (GSH) and superoxide dismutase (SOD) (Garcia-Bello et al. 2014).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Garcia-Bello et al. 2014
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- Authors
- Garcia-Bello, J. A., Gómez-Díaz, R. A., Contreras-Rodríguez, A., Talavera, J. O., Mondragón-González, R., Sanchez-Barbosa, L., Diaz-Flores, M., Valladares-Salgado, A., Gallardo, J. M., Aguilar-Kitsu, A., Lagunas-Munoz, J., & Wacher, N. H.
- Affiliations
- Mexican Social Security Institute (MX)
- Corresponding author
- Gómez-Díaz, Rita A.
- ORCID
- Venue
- Pediatric Nephrology
- Published
- 2013-09-28
- Volume
- 29
- Issue
- 2
- Pages
- 273-281
- ISSN
- 0931-041X (ISSN-L)
- 1432-198X
- OpenAlex
- W2126475784
- Cited by
- 26
- References
- 39
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pediatric Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- carotid intima-media thickness, pediatric chronic kidney disease, oxidative stress, inflammation, hemodialysis, peritoneal dialysis, parathyroid hormone, hyperphosphatemia, calcium-phosphate product, reduced glutathione, malondialdehyde, C-reactive protein, interleukin-6, nitric oxide, homocysteine
- MeSH terms
- Adolescent, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Inflammation, Male, Biomarkers, Oxidative Stress, Renal Insufficiency, Chronic, Elastic Modulus, Carotid Intima-Media Thickness
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