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Depression and anxiety in long-term survivors 5 and 10 years after cancer diagnosis
Abstract
Purpose Our study provides data on depression and anxiety in long-term cancer survivors, in men, women and various age groups, as well as identifies associated factors and coping-related resources.Methods We present data obtained from 1002 cancer survivors across a large variety of tumour entities 5 years (cohort 1) and 10 years (cohort 2) after diagnosis, in a cross-sectional study. We analysed depression (PHQ-9) and anxiety (GAD-7) symptomatology in comparison with two large age- and sex-matched samples randomly selected from the general population.Results Moderate to severe depression and anxiety were reported in 17% and 9% of cancer survivors, respectively. There were no significant differences between the 5 years and 10 years after diagnosis cohorts (p = 0.232). In both cohorts, we found higher depression and anxiety in women than in men (p < 0.001), and lower depression and anxiety in elderly patients (p < 0.001). Cancer survivors younger than 60 years of age were more depressed and anxious than the general population (p < 0.001). The variables, financial problems (Beta = 0.16, p < 0.001), global quality of life (Beta = - 0.21, p < 0.001) and cognitive function (Beta = - 0.30, p < 0.001), had the strongest association with depression and anxiety.Conclusions For the prevention of depression and anxiety in long-term cancer survivors, individual treatment of physical and psychological symptoms is as important as social support and professional counselling. Post-treatment, cognitive limitations should be carefully assessed in long-term cancer survivorship to distinguish them from symptoms of a mental disorder, especially since younger cancer survivors of working age and female survivors seem to be more affected by depression and anxiety.
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“once patients have reached later phases of the survivorship trajectory, elevated levels of distress have been found equally prevalent when comparing survivors at five and ten years after diagnosis (Götze et al., 2020).”
From Internet-delivered Mindfulness-Based Cognitive Therapy for anxiety and depression in cancer survivors: Predictors of treatment response (2021) · cites this paper as Götze et al., 2020
In the citing paper
“Generally, older age has been found related to lower levels of psychological distress in cancer patients (Linden et al., 2012; Götze et al., 2020)”
From Internet-delivered Mindfulness-Based Cognitive Therapy for anxiety and depression in cancer survivors: Predictors of treatment response (2021) · cites this paper as Götze et al., 2020
In the citing paper
“which has been found to be equally prevalent among cancer survivors after 5 to 10 years (Götze et al., 2020).”
From Internet-delivered Mindfulness-Based Cognitive Therapy for anxiety and depression in cancer survivors: Predictors of treatment response (2021) · cites this paper as Götze et al., 2020
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“Depression and anxiety are more common in female PWC.3,8-11”
From Mindfulness and Psychosocial Symptoms in People with Cancer: Testing Rumination and Experiential Avoidance as Mediators, and Sex as a Moderator. (2025) · cites this paper as [3]
In the citing paper
“Although short‐term ΝPI benefits for patients are frequently reported, 24 , 117 , 118 this modest dose may be insufficient to sustain psychological improvements because distress can (re‐)emerge in patients and caregivers during prolonged treatment. 119”
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Metadata
- Authors
- Götze, H., Friedrich, M., Taubenheim, S., Dietz, A., Lordick, F., & Mehnert, A.
- Affiliations
- University Hospital Leipzig (DE)
- Corresponding author
- Götze, Heide
- Venue
- Supportive Care in Cancer
- Published
- 2019-04-18
- Volume
- 28
- Issue
- 1
- Pages
- 211-220
- ISSN
- 0941-4355 (ISSN-L)
- 1433-7339
- OpenAlex
- W2940210168
- Cited by
- 281
- References
- 40
- Citations by year
- 2026: 16 · 2025: 57 · 2024: 68 · 2023: 58 · 2022: 33 · 2021: 32 · 2020: 16 · 2019: 1
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Supportive Care in Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- SWISS BRIDGE Foundation (Swiss Bridge Award 2013)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Keywords
- cancer survivors, depression, anxiety, long-term survivorship, sex differences, age differences, financial problems, quality of life, cognitive function, coping resources, psychological symptoms
- MeSH terms
- Cancer Survivors, Adolescent, Adult, Aged, Aged, 80 and over, Anxiety, Anxiety Disorders, Cross-Sectional Studies, Depression, Depressive Disorder, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasms, Quality of Life, Social Support, Cohort Studies, Case-Control Studies, Young Adult
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