Remimazolam besilate, a benzodiazepine, has been approved for general anesthesia!!

Consensus Guidelines for the Management of Postoperative Nausea and Vomiting

Gan, T. J., Diemunsch, P. A., Habib, A. S., Kovac, A. L., Kranke, P., Meyer, T. A., Watcha, M. F., Chung, F. F., Angus, S., Apfel, C. C., et al. (2013) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000000002 · Cited by 1,523

Context-sensitive Half-time in Multicompartment

Hughes, M. A., Glass, P. S. A., & Jacobs, J. R. (1992) · Anesthesiology · doi:10.1097/00000542-199203000-00003 · Cited by 802

Society for Ambulatory Anesthesia Guidelines for the Management of Postoperative Nausea and Vomiting

Gan, T. J., Meyer, T. A., Apfel, C. C., Chung, F. F., Davis, P. J., Habib, A. S., Hooper, V. D., Kovac, A. L., Kranke, P., Myles, P. S., et al. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000295230.55439.f4 · Cited by 716

HAEMODYNAMIC CHANGES DURING ANAESTHESIA INDUCED AND MAINTAINED WITH PROPOFOL

Claeys, M., Gepts, E., & Camu, F. (1988) · British Journal of Anaesthesia · doi:10.1093/bja/60.1.3 · Cited by 499

Untitled work

Kilpatrick (2007) · doi:10.1097/01.anes.0000267503.85085.c0 · Cited by 381

Prolonged sedation due to accumulation of conjugated metabolites of midazolam

Bauer, T., Ritz, R., Haberthür, C., Haefeli, W. E., Scollo‐Lavizzari, G., Ha, H. R., Hunkeler, W., & Sleight, A. J. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91209-6 · Cited by 334

Propofol infusion syndrome: a structured literature review and analysis of published case reports

Hemphill, S., McMenamin, L., Bellamy, M. C., & Hopkins, P. M. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2018.12.025 · Cited by 331

A Placebo- and Midazolam-Controlled Phase I Single Ascending-Dose Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Remimazolam (CNS 7056): Part I. Safety, Efficacy, and Basic Pharmacokinetics

Antonik, L. J., Goldwater, D. R., Kilpatrick, G., Tilbrook, G., & Borkett, K. (2012) · Anesthesia and Analgesia · doi:10.1213/ane.0b013e31823f0c28 · Cited by 321

A phase III study evaluating the efficacy and safety of remimazolam (CNS 7056) compared with placebo and midazolam in patients undergoing colonoscopy.

Rex, D., Bhandari, R., Desta, T., Demicco, M., Schaeffer, C., Etzkorn, K., Barish, C., Pruitt, R., Cash, B., Quirk, D., et al. (2018) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2018.04.2351 · Cited by 260

A Placebo- and Midazolam-Controlled Phase I Single Ascending-Dose Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Remimazolam (CNS 7056): Part II. Population Pharmacokinetic and Pharmacodynamic Modeling and Simulation

Wiltshire, H. R., Kilpatrick, G. J., Tilbrook, G. S., & Borkett, K. M. (2012) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318241f68a · Cited by 215

A Phase IIa, Randomized, Double-Blind Study of Remimazolam (CNS 7056) Versus Midazolam for Sedation in Upper Gastrointestinal Endoscopy

Borkett, K., Riff, D., Schwartz, H., Winkle, P., Pambianco, D. J., Lees, J., & Wilhelm-Ogunbiyi, K. (2015) · Anesthesia and Analgesia · doi:10.1213/ane.0000000000000548 · Cited by 194

Hypotension after induction of general anesthesia: occurrence, risk factors, and therapy. A prospective multicentre observational study

Jor, O., Máca, J., Jiřina Koutná, C., Gemrotova, M., Vymazal, T., Litschmannová, M., Ševčík, P., Reimer, P., Mikulova, V., Trlicova, M., et al. (2018) · Journal of Anesthesia · doi:10.1007/s00540-018-2532-6 · Cited by 191

A Phase Ib, Dose-Finding Study of Multiple Doses of Remimazolam (CNS 7056) in Volunteers Undergoing Colonoscopy

Worthington, M., Antonik, L. J., Goldwater, D. R., Lees, J., Wilhelm-Ogunbiyi, K., Borkett, K. M., & Mitchell, M. (2013) · Anesthesia and Analgesia · doi:10.1213/ane.0b013e3182a705ae · Cited by 160

Performance of Propofol Target-Controlled Infusion Models in the Obese

Cortínez, L. I., de la Fuente, N., Eleveld, D. J., Oliveros, A., Crovari, F. J., Sepúlveda, P., Ibacache, M. E., & Solari, S. (2014) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000000317 · Cited by 91

Early Phase Pharmacokinetics but Not Pharmacodynamics Are Influenced by Propofol Infusion Rate

Masui, K., Kira, M., Kazama, T., Hagihira, S., Mortier, E. P., & Struys, M. M. R. F. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181b799c1 · Cited by 81

Comparison of the sedative properties of CNS 7056, midazolam, and propofol in sheep

Upton, R. N., Martinez, A., & Grant, C. M. (2009) · British Journal of Anaesthesia · doi:10.1093/bja/aep269 · Cited by 70

A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEG and the respiratory and cardiovascular systems

Upton, R. N., Martinez, A. M., & Grant, C. M. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.228 · Cited by 57

Pharmacokinetics and pharmacodynamics of the short-acting sedative CNS 7056 in sheep

Upton, R. N., Somogyi, A. A., Martinez, A. M., Colvill, J., & Grant, C. M. (2010) · British Journal of Anaesthesia · doi:10.1093/bja/aeq260 · Cited by 49

Remimazolam: New Beginnings or Just a Me-Too?

Sneyd, J. R. (2012) · Anesthesia and Analgesia · doi:10.1213/ane.0b013e31823acb95 · Cited by 44

Paediatric total intravenous anaesthesia

Gaynor, J., & Ansermino, J. M. (2016) · BJA Education · doi:10.1093/bjaed/mkw019 · Cited by 42

Reduction of pain on injection of propofol using meperidine and remifentanil

Başaranoğlu, M., Erden, V., Delatioğlu, H., & Saitoğlu, L. (2005) · European Journal of Anaesthesiology · doi:10.1017/s0265021505231502 · Cited by 36

Waste anesthetic gas exposure and strategies for solution

Deng, H., Li, F., Cai, Y., & Xu, S. (2018) · Journal of Anesthesia · doi:10.1007/s00540-018-2448-1 · Cited by 35

Identification and Structure–Activity Studies of Novel Ultrashort-Acting Benzodiazepine Receptor Agonists

Stafford, J. A., Pacofsky, G. J., Cox, R. F., Cowan, J. R., Dorsey, G. F., Gonzales, S. S., Jung, D. K., Koszalka, G. W., McIntyre, M. S., Tidwell, J. H., et al. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)00512-7 · Cited by 30

Population pharmacokinetic analysis of propofol in underweight patients under general anaesthesia

Park, J. H., Choi, S., Park, J. H., Lee, K. H., Yun, H. J., Lee, E. K., Choi, B., & Noh, G. (2018) · British Journal of Anaesthesia · doi:10.1016/j.bja.2018.04.045 · Cited by 27

Comparison between hemodynamic effects of propofol and thiopental during general anesthesia induction with remifentanil infusion: a double-blind, age-stratified, randomized study

Hino, H., Matsuura, T., Kihara, Y., Tsujikawa, S., Mori, T., & Nishikawa, K. (2019) · Journal of Anesthesia · doi:10.1007/s00540-019-02657-x · Cited by 26

Effect of dexmedetomidine for attenuation of propofol injection pain in electroconvulsive therapy: a randomized controlled study

Li, X., Chen, C., Tan, F., Pan, J., Xing, J., Zhu, Q., Hei, Z., & Zhou, S. (2017) · Journal of Anesthesia · doi:10.1007/s00540-017-2430-3 · Cited by 24

Reversal of Midazolam-Induced Laryngospasm With Flumazenil

Davis, D. P., Hamilton, R. S., & Webster, T. H. (1998) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(98)70148-9 · Cited by 24

Population pharmacodynamic modelling of midazolam induced sedation in terminally ill adult patients

Franken, L. G. W., de Winter, B. C. M., Masman, A. D., van Dijk, M., Baar, F. P. M., Tibboel, D., Koch, B. C. P., van Gelder, T., & Mathôt, R. A. A. (2017) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13442 · Cited by 22

Procedural sedation and analgesia in the emergency department in Japan: interim analysis of multicenter prospective observational study

On behalf of the Japanese Procedural Sedation and Analgesia Registry investigators, Norii, T., Homma, Y., Shimizu, H., Takase, H., Kim, S., Nagata, S., Shimosato, A., & Crandall, C. S. (2019) · Journal of Anesthesia · doi:10.1007/s00540-018-02606-0 · Cited by 20

Comparison of TIVA with different combinations of ketamine–propofol mixtures in pediatric patients

Biricik, E., Karacaer, F., Güleç, E., Sürmelioğlu, Ö., Ilgınel, M. T., & Özcengiz, D. (2017) · Journal of Anesthesia · doi:10.1007/s00540-017-2438-8 · Cited by 13

Context sensitive decrement times of remimazolam.

Schnider, T., & Minto, C. (2013) · Anesthesia and Analgesia · doi:10.1213/ane.0b013e3182942954 · Cited by 11

Evaluation of pharmacokinetic models of intravenous dexmedetomidine in sedated patients under spinal anesthesia

Obara, S., Imaizumi, T., Hakozaki, T., Hosono, A., Iseki, Y., Sanbe, N., & Murakawa, M. (2017) · Journal of Anesthesia · doi:10.1007/s00540-017-2424-1 · Cited by 10

Rocuronium pharmacodynamic models for published five pharmacokinetic models: age and sex are covariates in pharmacodynamic models

Masui, K., Ishigaki, S., Tomita, A., & Otake, H. (2018) · Journal of Anesthesia · doi:10.1007/s00540-018-2543-3 · Cited by 7

The predictive ability of six pharmacokinetic models of rocuronium developed using a single bolus: evaluation with bolus and continuous infusion regimen

Sasakawa, T., Masui, K., Kazama, T., & Iwasaki, H. (2016) · Journal of Anesthesia · doi:10.1007/s00540-016-2174-5 · Cited by 7

Population pharmacokinetics of palonosetron and model-based assessment of dosing strategies

Lee, S., Kim, I., Pyeon, T., Lee, S., Song, J., Rhee, J., & Jeong, S. (2019) · Journal of Anesthesia · doi:10.1007/s00540-019-02641-5 · Cited by 3

Remimazolam: non-clinical and clinical profile of a new sedative/anesthetic agent

Kilpatrick, G. J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.690875 · Cited by 262

Remimazolam: pharmacological characteristics and clinical applications in anesthesiology

Kim, K. M. (2022) · Anesthesia and Pain Medicine · doi:10.17085/apm.21115 · Cited by 250

Remimazolam: An Updated Review of a New Sedative and Anaesthetic

Hu, Q.-X., Liu, X., Wen, C., Li, D., & Lei, X.-F. (2022) · Drug Design, Development and Therapy · doi:10.2147/dddt.s384155 · Cited by 185

Safety and efficacy of remimazolam compared with propofol in induction of general anesthesia.

Dai, G., Pei, L., Duan, F., Liao, M., Zhang, Y., Zhu, M., Zhao, Z.-B., & Zhang, X. (2021) · Minerva Anestesiologica · doi:10.23736/s0375-9393.21.15517-8 · Cited by 132

Effect of remimazolam induction on hemodynamics in patients undergoing valve replacement surgery: A randomized, double-blind, controlled trial

Liu, T., Lai, T., Chen, J., Lu, Y., He, F., Chen, Y., & Xie, Y. (2021) · Pharmacology Research & Perspectives · doi:10.1002/prp2.851 · Cited by 146

Remimazolam: First Approval

Keam, S. J. (2020) · Figshare · doi:10.6084/m9.figshare.12017124

Remimazolam – Update zu Grundlagen und klinischem Potenzial

Scheckenbach, V., & Drexler, B. (2024) · Die Anaesthesiologie · doi:10.1007/s00101-024-01450-0 · Cited by 1

Remimazolam: A New Ultra Short Acting Benzodiazepine

(2016) · Journal of Anesthesia & Critical Care Open Access · doi:10.15406/jaccoa.2016.04.00166 · Cited by 3

Remimazolam: an ultrashort-acting intravenous anesthetic suitable for general anesthesia

CARDIA, L. (2021) · Minerva Anestesiologica · doi:10.23736/s0375-9393.21.16006-7 · Cited by 16

Research Progress of Remimazolam in Induction and Maintenance of General An-esthesia

Yan, J.-W. (2022) · Advances in Clinical Medicine · doi:10.12677/acm.2022.126759