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Clinical practice guidelines for the management of non-specific low back pain in primary care: an updated overview
Open accessAbstract
OBJECTIVE: The aim of this study was to provide an overview of the recommendations regarding the diagnosis and treatment contained in current clinical practice guidelines for patients with non-specific low back pain in primary care. We also aimed to examine how recommendations have changed since our last overview in 2010. METHOD: The searches for clinical practice guidelines were performed for the period from 2008 to 2017 in electronic databases. Guidelines including information regarding either the diagnosis or treatment of non-specific low back pain, and targeted at a multidisciplinary audience in the primary care setting, were considered eligible. We extracted data regarding recommendations for diagnosis and treatment, and methods for development of guidelines. RESULTS: We identified 15 clinical practice guidelines for the management of low back pain in primary care. For diagnosis of patients with non-specific low back pain, the clinical practice guidelines recommend history taking and physical examination to identify red flags, neurological testing to identify radicular syndrome, use of imaging if serious pathology is suspected (but discourage routine use), and assessment of psychosocial factors. For treatment of patients with acute low back pain, the guidelines recommend reassurance on the favourable prognosis and advice on returning to normal activities, avoiding bed rest, the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and weak opioids for short periods. For treatment of patients with chronic low back pain, the guidelines recommend the use of NSAIDs and antidepressants, exercise therapy, and psychosocial interventions. In addition, referral to a specialist is recommended in case of suspicion of specific pathologies or radiculopathy or if there is no improvement after 4 weeks. While there were a few discrepancies across the current clinical practice guidelines, a substantial proportion of recommendations was consistently endorsed. In the current review, we identified some differences compared to the previous overview regarding the recommendations for assessment of psychosocial factors, the use of some medications (e.g., paracetamol) as well as an increasing amount of information regarding the types of exercise, mode of delivery, acupuncture, herbal medicines, and invasive treatments. These slides can be retrieved under Electronic Supplementary Material.
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“Most clinical practice guidelines endorse the use of psychological treatments for chronic LBP.16”
From Psychological interventions for chronic, non-specific low back pain: systematic review with network meta-analysis (2022) · cites this paper as [16]
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“However, existing guidelines typically provide generic or incomplete recommendations.”
From Psychological interventions for chronic, non-specific low back pain: systematic review with network meta-analysis (2022) · cites this paper as [16]
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“Existing guidelines consistently endorse that exercise and psychosocial therapies should be prescribed for management of chronic LBP.16”
From Psychological interventions for chronic, non-specific low back pain: systematic review with network meta-analysis (2022) · cites this paper as [16]
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Goode, A. P., Goertz, C., Chakraborty, H., Salsbury, S. A., Broderick, S., Levy, B. T., Ryan, K., Settles, S. J., Hort, S. J., Dolor, R. J., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-097133 · Cited by 2
Predictors of treatment adherence in patients with centralized low back pain
Watson, S., Trudelle-Jackson, E. J., Weber, M. D., & Brizzolara, K. J. (2025) · Journal of Back and Musculoskeletal Rehabilitation · doi:10.1177/10538127251332211 · Cited by 2
Rhon, D. I., George, S. Z., Parsons, N., & Fritz, J. M. (2025) · Journal of Pain · doi:10.1016/j.jpain.2025.105414 · Cited by 2
Beneciuk, J. M., Bialosky, J. E., Hayes, J. R., Buzzanca-Fried, K. E., Rowe, R., Cristello, S., Harrison, T., Vickers, R., & Shan, G. (2025) · BMJ Open · doi:10.1136/bmjopen-2025-099932 · Cited by 2
Longtin, C., Salisbury, A., Maher, C. G., Sharma, S., Nickel, B., Lung, T. W.-C., Ferreira, G. E., Shaheed, C. A., Furmage, A., Tousignant‐Laflamme, Y., et al. (2025) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.2025.13409 · Cited by 2
Self-citationFurlong, B., Frey, M., Davidson, S. R. E., Ferreira, G. E., Etchegary, H., Aubrey‐Bassler, K., & Hall, A. M. (2025) · Musculoskeletal Science and Practice · doi:10.1016/j.msksp.2025.103430 · Cited by 2
Bianchi, G., Zweifel, C., Hohenauer, E., Santos, J. A., & Clijsen, R. (2025) · Frontiers in Musculoskeletal Disorders · doi:10.3389/fmscd.2025.1672539 · Cited by 2
Tian, M., Qi, B., Zeng, J., Chen, J., & Lin, M. T. (2025) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-025-09296-2 · Cited by 2
Complications during lumbar selective nerve root block: a scoping review
Welinder, A. F., Kocemba, D., Kuang, V. H., & Rasmussen, M. M. (2025) · Acta Neurochirurgica · doi:10.1007/s00701-025-06747-6 · Cited by 2
Cioeta, M., Giannotta, G., Carbotti, D., Cicinelli, D., Giovinazzi, R., Dell’Anna, A., Germani, A., Balestra, F., Giovannico, G., Mourad, F., et al. (2025) · Musculoskeletal Science and Practice · doi:10.1016/j.msksp.2025.103477 · Cited by 2
Responsiveness of central sensitization-related measures in older people with chronic low back pain
Marques, L. B. F., Nogueira, L. A. C., Nascimento, R. R., Lemuchi, M. C. V., Esposito, E., Linke, J., Franco, M. R., Freire, A. P. C. F., & Pinto, R. Z. (2026) · Musculoskeletal Science and Practice · doi:10.1016/j.msksp.2026.103519 · Cited by 2
Self-citationDe-implementing spinal injections in pursuit of value-based care: Rethinking pain relief
Ballengee, L. A., Lentz, T. A., Goertz, C., McStay, F. W., Morken, I., & George, S. Z. (2026) · Journal of Pain · doi:10.1016/j.jpain.2026.106245 · Cited by 2
Migliorini, F., Schäfer, L., Simeone, F., Memminger, M. K., Eschweiler, J., & Vaishya, R. (2026) · European journal of medical research · doi:10.1186/s40001-026-04084-7 · Cited by 3
Cholewicki, J., Hodges, P. W., Popovich, J. M., Aminpour, P., Gray, S., Lee, A. S., Breen, A. C., Brumagne, S., van Dieën, J. H., Dillen, L. R. V., et al. (2026) · European Spine Journal · doi:10.1007/s00586-026-09932-y · Cited by 2
Self-citationCorrêa, L. A., Hancock, M. J., Mathieson, S., Nogueira, L. A. C., Silva, T., Saragiotto, B. T., Fernandes, L. A. P. P., Darlow, B. J. S., & French, S. D. (2026) · Brazilian Journal of Physical Therapy · doi:10.1016/j.bjpt.2026.101600 · Cited by 2
Non-Invasive Brain Stimulation for Core Symptoms of Chronic Primary Pain: A Meta-Analysis of RCTs
Telesca, A., Vergallito, A., Vedani, A., Locatelli, G., Visiello, B., Pinter, G. L., & Lauro, L. J. R. (2026) · Brain Sciences · doi:10.3390/brainsci16070663 · Cited by 3
Bannikova, R., Kormiltsev, V., Брушко, В., & Balazh, M. (2019) · Слобожанський науково-спортивний вісник · doi:10.15391/snsv.2019-1.007 · Cited by 2
Clinical reasoning in physiotherapy management of acute lumbar radiculopathy
Smythe, A. J. (2020) · Medical Case reports and Reviews · doi:10.15761/mcrr.1000148 · Cited by 2
Self-Management and Low Back Pain
Diener, I. (2021) · Springer eBooks · doi:10.1007/978-3-030-69736-5_6 · Cited by 2
Sørensen, B. Ø., & Straszek, C. L. (2021) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2021.1920075 · Cited by 2
Gangi, S. D., Bagnoud, C., Pichierri, G., Rosemann, T. J., & Plate, A. (2021) · Journal of Pain Research · doi:10.2147/jpr.s328033 · Cited by 2
Metadata
- Authors
- Oliveira, C. B., Maher, C. G., Pinto, R. Z., Traeger, A. C., Lin, C.-W. C., Chenot, J.-F., van Tulder, M., & Koes, B. W.
- Affiliations
- Universidade Estadual Paulista (Unesp) (BR)
- Universidade Federal de Minas Gerais (BR)
- The University of Sydney (AU)
- Universitätsmedizin Greifswald (DE)
- University of Southern Denmark (DK)
- Corresponding author
- Koes, Bart W.
- ORCID
- Venue
- European Spine Journal
- Published
- 2018-07-03
- Volume
- 27
- Issue
- 11
- Pages
- 2791-2803
- ISSN
- 0940-6719 (ISSN-L)
- 1432-0932
- OpenAlex
- W2811473826
- Cited by
- 1,584
- References
- 31
- Citations by year
- 2026: 140 · 2025: 212 · 2024: 275 · 2023: 235 · 2022: 241 · 2021: 241 · 2020: 149 · 2019: 74 · 2018: 13
- FWCI
- 13.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- European Spine Journal (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- VU Research Portal (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (88881.134663/2016-01)
- National Health and Medical Research Council (APP1103022, APP1144026, APP1061400)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Clinical practice guidelines implementation
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Spine and Intervertebral Disc Pathology
- Keywords
- non-specific low back pain, primary care, diagnosis, treatment, acute low back pain, chronic low back pain, red flags, radiculopathy, imaging, psychosocial factors, nonsteroidal anti-inflammatory drugs, antidepressants, exercise therapy, specialist referral, guideline recommendations
- MeSH terms
- Humans, Primary Health Care, Low Back Pain, Practice Guidelines as Topic
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