Cited by 110Chronic Kidney Disease and DiabetesRenal Diseases and GlomerulopathiesAdipokines, Inflammation, and Metabolic Diseases

Effect of TNF-α inhibition on urinary albumin excretion in experimental diabetic rats

Moriwaki, Yuji, Inokuchi, Taku, Yamamoto, Asako, Ka, Tsuneyoshi, Tsutsumi, Zenta, Takahashi, Sumio, Yamamoto, Tetsuya·2007·Acta Diabetologica

Abstract

The objective is to assess the effect of TNF-alpha inhibition on urinary albumin excretion in experimental diabetic rats. Male Wistar rats, 8-week-old, were categorized into four groups, which were the control (n = 9), diabetes (n = 9), infliximab-treated diabetes (n = 10), and FR167653-treated diabetes (n = 9) groups. Diabetes was induced by intraperitoneal injection of STZ (40 mg/kg). Thereafter, infliximab was injected intraperitoneally once a month (5.5 mg/kg) and FR167653 was administered orally by mixing with the rat chow (0.08%). The effects of infliximab and FR167653 on urinary albumin excretion were observed for 12 weeks. Body weight, blood sugar, 24-h urinary TNF-alpha, and 24-h urinary albumin/creatinine ratio (Ualb/Ucr) levels were determined at 1, 4, 8, and 12 weeks after the STZ-injection. Treatment of rats with STZ caused a significant loss of body weight, as well as polyuria and hyperglycemia within 1 week, while the urinary excretions of albumin and TNF-alpha were increased. Neither infliximab nor FR167653 affected body weight or blood sugar levels, whereas both decreased urinary albumin excretion, together with a modest decrease in the urinary excretion of TNF-alpha. These results suggest a role of TNF-alpha in the pathogenesis of diabetic nephropathy and show that TNF-alpha inhibition is a potential therapeutic strategy.

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Crossref · 10.1007/s00592-007-0007-6

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Authors
Moriwaki, Y., Inokuchi, T., Yamamoto, A., Ka, T., Tsutsumi, Z., Takahashi, S., & Yamamoto, T.
Affiliations
Hyogo Medical University (JP)
Corresponding author
Moriwaki, Yuji
Venue
Acta Diabetologica
Published
2007-09-01
Volume
44
Issue
4
Pages
215-218
ISSN
  • 0940-5429 (ISSN-L)
  • 1432-5233
OpenAlex
W2035793960
Cited by
110
References
19
Citations by year
2025: 4 · 2024: 1 · 2023: 6 · 2022: 8 · 2021: 6 · 2020: 9 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 7 · 2014: 9 · 2013: 5 · 2012: 15
FWCI
3.86
Type
journal article
Language
en
Open access
closed
Locations
  • Acta Diabetologica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
anti-TNF therapy, urinary albumin excretion, diabetic nephropathy, infliximab, FR167653, streptozotocin-induced diabetes, TNF-α, albuminuria
MeSH terms
Infliximab, Albuminuria, Animals, Anti-Inflammatory Agents, Non-Steroidal, Antibodies, Monoclonal, Diabetes Mellitus, Experimental, Male, Pyrazoles, Pyridines, Tumor Necrosis Factor-alpha, Rats, Wistar, Rats

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