Insulin-like growth factor binding protein: a possible marker for the metabolic syndrome?
Abstract
Insulin-like growth factor (IGF) binding proteins (IGFBPs) moved on to contain both IGF high- and low-affinity binders, exerting mitogenic and metabolic actions through its complex interplay between IGF/insulin and its IGF/insulin-independent manner. Progress on the metabolic-related function of IGFBPs has been rapid in recent years. A wealth of studies in 3T3-L1 adipocytes and the transgenic mice models demonstrated that IGFBPs played important roles in the pathogenesis of obesity and insulin resistance. Studies conducted in humans demonstrated the close relation between IGFBPs and the components of the metabolic syndrome. Abnormal expression of IGFBP was detected in various states of the metabolic disorders, suggesting that it could be used as a convenient and sensitive marker of insulin resistance, identification of insulin-resistant individuals at high cardiovascular risk, and may be an earlier marker of the metabolic syndrome. These exciting findings bring us new insight into the elucidation of the metabolic syndrome, which may have important clinical implications.
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The progression of DCM has been linked to cardiomyocyte hypertrophy and increased fibrosis.
“Structurally, the progression of DCM has been linked to cardiomyocyte hypertrophy and increased fibrosis [26-29].”
From Role of Serum Biomarkers in Early Detection of Diabetic Cardiomyopathy in the West Virginian Population (2016) · cites this paper as [27]
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“Structurally, the progression of DCM has been linked to cardiomyocyte hypertrophy and increased fibrosis [26-29].”
- Authors
- Ruan, W., & Lai, M.
- Affiliations
- Zhejiang University (CN)
- Corresponding author
- Lai, Maode
- Venue
- Acta Diabetologica
- Published
- 2009-09-22
- Volume
- 47
- Issue
- 1
- Pages
- 5-14
- ISSN
- 0940-5429 (ISSN-L)
- 1432-5233
- OpenAlex
- W1978025072
- Cited by
- 96
- References
- 6
- Citations by year
- 2025: 6 · 2024: 4 · 2021: 1 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 11 · 2016: 6 · 2015: 7 · 2014: 5 · 2013: 7 · 2012: 18
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Diabetologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- IGF binding proteins, metabolic syndrome, insulin resistance, obesity, biomarkers, cardiovascular risk, adipocytes
- MeSH terms
- Animals, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Insulin, Insulin Resistance, Obesity, Predictive Value of Tests, Somatomedins, Biomarkers, Adipocytes, Glucose Intolerance, Insulin-Like Growth Factor Binding Proteins, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor Binding Protein 2, Models, Animal, Metabolic Syndrome
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