Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD+ oscillation
Open accessAbstract
The Intracellular levels of nicotinamide adenine dinucleotide (NAD(+)) are rhythmic and controlled by the circadian clock. However, whether NAD(+) oscillation in turn contributes to circadian physiology is not fully understood. To address this question we analyzed mice mutated for the NAD(+) hydrolase CD38. We found that rhythmicity of NAD(+) was altered in the CD38-deficient mice. The high, chronic levels of NAD(+) results in several anomalies in circadian behavior and metabolism. CD38-null mice display a shortened period length of locomotor activity and alteration in the rest-activity rhythm. Several clock genes and, interestingly, genes involved in amino acid metabolism were deregulated in CD38-null livers. Metabolomic analysis identified alterations in the circadian levels of several amino acids, specifically tryptophan levels were reduced in the CD38-null mice at a circadian time paralleling with elevated NAD(+) levels. Thus, CD38 contributes to behavioral and metabolic circadian rhythms and altered NAD(+) levels influence the circadian clock.
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NAD+ is widely used as a cofactor or substrate for biochemical reactions, with more than 300 enzymes relying on NAD+ for their activity.
“Beyond the main groups of NAD+-consuming enzymes discussed so far, NAD+ is widely used as a cofactor or substrate for biochemical reactions, with more than 300 enzymes1 relying on NAD+ for their activity.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [1]
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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510 · see citing works
Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001 · see citing works
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611 · see citing works
Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen, D., Guarente, L. P., & Sassone-Corsi, P. (2008) · Cell · doi:10.1016/j.cell.2008.07.002 · Cited by 1,427 · see citing works
Self-citationSIRT1 regulates circadian clock gene expression through PER2 deacetylation
Asher, G., Gatfield, D., Stratmann, M., Reinke, H., Dibner, C., Kreppel, F., Mostoslavsky, R., Alt, F. W., & Schibler, U. (2008) · Cell · doi:10.1016/j.cell.2008.06.050 · Cited by 1,376 · see citing works
Fu, L., Pelicano, H., Liu, J., Huang, P., & Lee, C. C. (2002) · Cell · doi:10.1016/s0092-8674(02)00961-3 · Cited by 1,256 · see citing works
Circadian Control of the NAD <sup>+</sup> Salvage Pathway by CLOCK-SIRT1
Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M., & Sassone-Corsi, P. (2009) · Science · doi:10.1126/science.1170803 · Cited by 1,198 · see citing works
Self-citationCircadian Clock Feedback Cycle Through NAMPT-Mediated NAD <sup>+</sup> Biosynthesis
Ramsey, K. M., Yoshino, J., Brace, C. S., Abrassart, D., Kobayashi, Y., Marcheva, B., Hong, H.-K., Chong, J. L., Buhr, E. D., Lee, C., et al. (2009) · Science · doi:10.1126/science.1171641 · Cited by 1,126 · see citing works
Circadian Regulator CLOCK Is a Histone Acetyltransferase
Doi, M., Hirayama, J., & Sassone‐Corsi, P. (2006) · Cell · doi:10.1016/j.cell.2006.03.033 · Cited by 890 · see citing works
Self-citationPost-translational modifications regulate the ticking of the circadian clock
Gallego, M., & Virshup, D. M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2106 · Cited by 863 · see citing works
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology
Malavasi, F., Deaglio, S., Funaro, A., Ferrero, E., Horenstein, A. L., Ortolan, E., Vaisitti, T., & Aydin, S. (2008) · Physiological Reviews · doi:10.1152/physrev.00035.2007 · Cited by 862 · see citing works
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
Bai, P., Cantó, C., Oudart, H., Brunyánszki, A., Cen, Y., Thomas, C., Yamamoto, H., Huber, A., Kiss, B., Houtkooper, R. H., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.004 · Cited by 837 · see citing works
Schibler, U., & Sassone‐Corsi, P. (2002) · Cell · doi:10.1016/s0092-8674(02)01225-4 · Cited by 752 · see citing works
Self-citationSirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice
Banks, A. S., Kon, N., Knight, C. M., Matsumoto, M., Juárez, R. G., Rossetti, L., Gu, W. J., & Accili, D. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.014 · Cited by 639 · see citing works
Metabolism and cancer: the circadian clock connection
Sahar, S., & Sassone-Corsi, P. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2747 · Cited by 551 · see citing works
Self-citationCLOCK-mediated acetylation of BMAL1 controls circadian function
Hirayama, J., Sahar, S., Grimaldi, B., Tamaru, T., Takamatsu, K., Nakahata, Y., & Sassone‐Corsi, P. (2007) · Nature · doi:10.1038/nature06394 · Cited by 525 · see citing works
Self-citationA clock shock: mouse CLOCK is not required for circadian oscillator function
DeBruyne, J. P., Noton, E., Lambert, C. M., Maywood, E. S., Weaver, D. R., & Reppert, S. M. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.041 · Cited by 430 · see citing works
Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice
Dudley, C. A., Erbel-Sieler, C., Estill, S. J., Reick, M., Franken, P., Pitts, S., & McKnight, S. L. (2003) · Science · doi:10.1126/science.1082795 · Cited by 415 · see citing works
Regulation of intracellular levels of NAD: A novel role for CD38
Aksoy, P., White, T. A., Thompson, M., & Chini, E. N. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.042 · Cited by 353 · see citing works
Self-citationPoly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
Asher, G., Reinke, H., Altmeyer, M., Gutierrez-Arcelus, M., Hottiger, M. O., & Schibler, U. (2010) · Cell · doi:10.1016/j.cell.2010.08.016 · Cited by 340 · see citing works
NUTRITIONAL CONTROL OF GENE EXPRESSION: How Mammalian Cells Respond to Amino Acid Limitation
Kilberg, M. S., Pan, Y., Chen, H., & Leung‐Pineda, V. (2005) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132145 · Cited by 288 · see citing works
Quantitative Metabolomics by 1H-NMR and LC-MS/MS Confirms Altered Metabolic Pathways in Diabetes
Lanza, I. R., Zhang, S., Ward, L. E., Karakelides, H., Raftery, D., & Nair, K. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010538 · Cited by 267 · see citing works
Measurement of internal body time by blood metabolomics
Minami, Y., Kasukawa, T., Kakazu, Y., Iigo, M., Sugimoto, M., Ikeda, S., Yasui, A., van der Horst, G. T. J., Soga, T., & Ueda, H. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900617106 · Cited by 261 · see citing works
PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
Bai, P., Cantó, C., Brunyánszki, A., Huber, A., Szántó, M., Cen, Y., Yamamoto, H., Houten, S. M., Kiss, B., Oudart, H., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.013 · Cited by 250 · see citing works
Synthesis and Degradation of Cyclic ADP-Ribose by NAD Glycohydrolases
Kim, H.-T., Jacobson, E. L., & Jacobson, M. K. (1993) · Science · doi:10.1126/science.8395705 · Cited by 250 · see citing works
Barbosa, M. T., Soares, S. M., Novak, C. M., Sinclair, D. A., Levine, J. A., Aksoy, P., & Chini, E. N. (2007) · The FASEB Journal · doi:10.1096/fj.07-8290com · Cited by 249 · see citing works
Self-citationCockayne, D. A., Muchamuel, T., Grimaldi, J. C., Muller‐Steffner, H., Randall, T. D., Lund, F. E., Murray, R., Schuber, F. J., & Howard, M. (1998) · Blood · doi:10.1182/blood.v92.4.1324 · Cited by 219 · see citing works
Kolthur‐Seetharam, U., Dantzer, F., McBurney, M. W., de MURCIA, G., & Sassone‐Corsi, P. (2006) · Cell Cycle · doi:10.4161/cc.5.8.2690 · Cited by 203 · see citing works
Self-citationChini, E. N. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209787185788 · Cited by 192 · see citing works
Self-citationAksoy, P., Escande, C., White, T. A., Thompson, M., Soares, S. M., Benech, J. C., & Chini, E. N. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.08.066 · Cited by 173 · see citing works
Self-citationMetabolism control by the circadian clock and vice versa
Eckel‐Mahan, K. L., & Sassone‐Corsi, P. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1595 · Cited by 146 · see citing works
Self-citationStraus, D. S., Burke, E. J., & Marten, N. W. (1993) · Endocrinology · doi:10.1210/endo.132.3.7679969 · Cited by 98 · see citing works
Insulin-like growth factor binding protein: a possible marker for the metabolic syndrome?
Ruan, W., & Lai, M. (2010) · Acta Diabetologica · doi:10.1007/s00592-009-0142-3 · Cited by 96 · see citing works
Decreased cADPR and increased NAD+ in the Cd38−/− mouse
Young, G. S., Choleris, E., Lund, F. E., & Kirkland, J. B. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.100 · Cited by 94 · see citing works
Regulation of asparagine synthetase gene expression by amino acid starvation.
Gong, S. S., Guerrini, L., & Basilico, C. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.12.6059 · Cited by 93 · see citing works
Bruhat, A., Avérous, J., Carraro, V., Zhong, C., Reimold, A. M., Kilberg, M. S., & Fafournoux, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206149200 · Cited by 82 · see citing works
Impaired adipogenesis in insulin-like growth factor binding protein-1 transgenic mice
Rajkumar, K., Modric, T., & Murphy, L. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1620457 · Cited by 79 · see citing works
Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock
Masubuchi, S., Gao, T., O’Neill, A., Eckel‐Mahan, K. L., Newton, A. C., & Sassone‐Corsi, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910292107 · Cited by 56 · see citing works
Self-citationFoxO-dependent and -independent mechanisms mediate SirT1 effects on IGFBP-1 gene expression
Gan, L., Han, Y.-S., Bastianetto, S., Dumont, Y., Unterman, T. G., & Quirion, R. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.09.169 · Cited by 54 · see citing works
Hoshino, S.-I., Kukimoto, I., Kontani, K., Inoue, S., Kanda, Y., Malavasi, F., & Katada, T. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.2.741 · Cited by 51 · see citing works
Hou, T. Y., Ward, S. M., Murad, J., Watson, N. P., Israel, M. A., & Duffield, G. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.013961 · Cited by 28 · see citing works
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Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00313-x · Cited by 1,617 · see citing works
Timing to perfection: the biology of central and peripheral circadian clocks
Albrecht, U. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.006 · Cited by 915 · see citing works
NAD+ homeostasis in health and disease
Katsyuba, E., Romani, M., Hofer, D., & Auwerx, J. (2020) · Nature Metabolism · doi:10.1038/s42255-019-0161-5 · Cited by 627 · see citing works
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Liu, L., Su, X., Quinn, W. J., Hui, S., Krukenberg, K., Frederick, D. W., Redpath, P., Zhan, L., Chellappa, K., White, E., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.018 · Cited by 564 · see citing works
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Etchegaray, J., & Mostoslavsky, R. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.029 · Cited by 521 · see citing works
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Marcheva, B., Ramsey, K. M., Peek, C. B., Affinati, A., Maury, E., & Bass, J. (2013) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-25950-0_6 · Cited by 282 · see citing works
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Feng, D., & Lazar, M. A. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.026 · Cited by 271 · see citing works
“Intracelluar NAD levels are circadian and are critical for circadian clock functions (Sahar et al., 2011).”
Regulation of metabolism: the circadian clock dictates the time
Sahar, S., & Sassone-Corsi, P. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.10.005 · Cited by 222 · see citing works
Self-citationCircadian regulation of metabolism
Bailey, S. M., Udoh, U. S., & Young, M. E. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0200 · Cited by 211 · see citing works
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Oike, H., Oishi, K., & Kobori, M. (2014) · Current Nutrition Reports · doi:10.1007/s13668-014-0082-6 · Cited by 198 · see citing works
Clock Genes and Clock-Controlled Genes in the Regulation of Metabolic Rhythms
Mazzoccoli, G., Pazienza, V., & Vinciguerra, M. (2012) · Chronobiology International · doi:10.3109/07420528.2012.658127 · Cited by 171 · see citing works
Chini, C. C. S., Guerrico, A. M. G., Nin, V., Camacho-Pereira, J., Escande, C., Barbosa, M. T., & Chini, E. N. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0150 · Cited by 147 · see citing works
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Berger, S. L., & Sassone‐Corsi, P. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019463 · Cited by 141 · see citing works
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Song, Q., Zhou, X., Xu, K., Liu, S., Zhu, X., & Yang, J. J. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.08.008 · Cited by 122 · see citing works
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Bellet, M. M., Nakahata, Y., Boudjelal, M., Watts, E. F., Mossakowska, D. E., Edwards, K. A., Cervantes, M., Astarita, G., Loh, C., Ellis, J. L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214266110 · Cited by 105 · see citing works
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Bellet, M. M., Orozco-Solís, R., Sahar, S., Eckel‐Mahan, K. L., & Sassone‐Corsi, P. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010520 · Cited by 89 · see citing works
Self-citationSirtuins and the circadian clock: Bridging chromatin and metabolism
Masri, S., & Sassone‐Corsi, P. (2014) · Science Signaling · doi:10.1126/scisignal.2005685 · Cited by 88 · see citing works
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Lee, W., Milewski, T. M., Dwortz, M. F., Young, R. L., Gaudet, A. D., Fonken, L. K., Champagne, F. A., & Curley, J. P. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.04.015 · Cited by 42 · see citing works
Williams, A. C., Hill, L. J., & Ramsden, D. B. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/302875 · Cited by 41 · see citing works
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Balashova, N. V., Zavileyskiy, L. G., Artiukhov, A. V., Shaposhnikov, L. A., Op, S., Tishkov, V. I., Tramonti, A., POMETUN, A. A., & Bunik, V. I. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.886485 · Cited by 18 · see citing works
Hashimoto, S., Gamage, U. S. K., Inoue, Y., Iwata, H., & Morimoto, Y. (2025) · Scientific Reports · doi:10.1038/s41598-024-81393-z · Cited by 14 · see citing works
NAD + deficiency in human congenital malformations and miscarriage: A new model of pleiotropy
Mark, P. R. (2022) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.62764 · Cited by 15 · see citing works
The use of Nicotinamide and Nicotinamide riboside as an adjunct therapy in the treatment of glaucoma
Silva, S. G. N. E., Occhiutto, M. L., & Costa, V. P. (2023) · European Journal of Ophthalmology · doi:10.1177/11206721231161101 · Cited by 14 · see citing works
Lakin‐Thomas, P. L. (2018) · Current Genetics · doi:10.1007/s00294-018-0897-6 · Cited by 12 · see citing works
Metcalfe, M., David, B. T., Langley, B. C., & Hill, C. E. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114479 · Cited by 11 · see citing works
Liu, X., Wu, Y., Jiang, W., Ma, K., Du, J., & Li, J. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.106701 · Cited by 10 · see citing works
Circadian Rhythms in Liver Physiology and Liver Diseases
Tong, X., & Yin, L. (2013) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2013.tb00505.x · Cited by 46 · see citing works
Viewing teratogens through the lens of nicotinamide adenine dinucleotide ( NAD +)
Mark, P. R., & Dunwoodie, S. L. (2022) · Birth Defects Research · doi:10.1002/bdr2.2089 · Cited by 6 · see citing works
Circadian Measurements of Sirtuin Biology
Ramsey, K. M., Affinati, A. H., Peek, C. B., Marcheva, B., Hong, H., & Bass, J. T. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-637-5_19 · Cited by 6 · see citing works
Circadian-disruption-induced gene expression changes in rodent mammary tissues
Kochan, D. Z., Ilnytskyy, Y., Golubov, A., Deibel, S. H., McDonald, R. J., & Kovalchuk, O. (2016) · Oncoscience · doi:10.18632/oncoscience.292 · Cited by 6 · see citing works
The role of circadian and redox rhythms in cancer hypoxia
Omer, S., Karunagaran, D., & Suraishkumar, G. K. (2021) · Advances in Redox Research · doi:10.1016/j.arres.2021.100018 · Cited by 5 · see citing works
Understanding the intricacies of cellular mechanisms in remyelination: The role of circadian rhythm
Tang, Y., Zhang, L., Huang, P., She, Z., Luo, S., Peng, H., Chen, Y., Luo, J., Duan, W., Xiao, Y., et al. (2025) · Neurochemistry International · doi:10.1016/j.neuint.2025.105929 · Cited by 4 · see citing works
Fan, Z., Liu, X., Gao, W., Zhang, L., Yang, X., & Li, J. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250275 · Cited by 3 · see citing works
Lee, W., Milewski, T. M., Dwortz, M. F., Young, R. L., Gaudet, A. D., Fonken, L. K., Champagne, F. A., & Curley, J. P. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.04.458987 · Cited by 3 · see citing works
Shi, Y., Wan, L., Jiao, M., Zhong, C., Cui, H., & Yuan, J. (2025) · Nature Communications · doi:10.1038/s41467-025-57517-y · Cited by 2 · see citing works
Yang, Y., Jiang, Z., Cheng, S., Wang, Y., Liu, Y., Xiao, J., Guo, H., Li, S., Hou, W., & Wang, Z. (2013) · Biological Rhythm Research · doi:10.1080/09291016.2013.842378 · Cited by 2 · see citing works
The role of biological clock in glucose homeostasis
Chrościcki, P., Usarek, M., & Bryła, J. (2013) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.5604/17322693.1053906 · Cited by 2 · see citing works
Sirtuins and the Circadian Clock: Epigenetic and Metabolic Crosstalk
Masri, S., Bellet, M. M., & Sassone‐Corsi, P. (2016) · Springer eBooks · doi:10.1007/978-94-024-0962-8_11 · Cited by 1 · see citing works
Self-citationPodkolodnyy, N. L., Tverdokhleb, N. N., & Podkolodnaya, O. A. (2017) · Russian Journal of Genetics Applied Research · doi:10.1134/s2079059717050161 · Cited by 1 · see citing works
Epigenomic and Transcriptional Regulation of Hepatic Metabolism by REV-ERB and Hdac3
Feng, D. (2013) · ScholarlyCommons (University of Pennsylvania) · Cited by 1 · see citing works
Salmina, A. B., Morgun, A. V., Сергеевна, О. О., Lopatina, O. L., Фурсов, А. А., Voino-Yasenetsky, V. F., & Russian Federation (2013) · CyberLeninK (CyberLeninka)
Fu, Z., Li, L., Xia, Y., Yao, B., Liu, Y., & Ding, H. (2022) · Research Square · doi:10.21203/rs.3.rs-1925619/v1
Nicotinamide Adenine Dinucleotide and Heart Disease
Zhao, K., Zhu, J., & Sheng, R. (2025) · Springer eBooks · doi:10.1007/978-981-97-9877-3_23
Coenzyme I and Biological Rhythm
Pan, S.-Y., & Luo, L. (2025) · Springer eBooks · doi:10.1007/978-981-97-9877-3_19
ERα activates NAMPT/IL-33 signaling to enhance beige thermogenesis and metabolic fitness
Hu, R., Park, J., Qian, Y., Xiong, S., Elsabbagh, A. H., Chhikara, A., FAN, H., Shi, Z., Liu, L., Li, Y., et al. (2026) · Science Advances · doi:10.1126/sciadv.adz1385
Liu, X., Fan, Z., Jiang, W., Gao, W., Yang, X., & Li, J. (2026) · Food Science and Human Wellness · doi:10.26599/fshw.2025.9250496
- Authors
- Sahar, S., Nin, V., Barbosa, M. T., Chini, E. N., & Sassone-Corsi, P.
- Affiliations
- Inserm (FR)
- Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55902, USA
- Mayo Clinic (US)
- Department of Pharmacology, University of California, Irvine, CA 92697, USA
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2011-08-31
- Volume
- 3
- Issue
- 8
- Pages
- 794-802
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC3184980
- OpenAlex
- W2143380761
- Cited by
- 79
- References
- 41
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 1 · 2023: 7 · 2022: 7 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 15 · 2012: 6
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Aging (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- American Federation for Aging Research
- Mayo Foundation for Medical Education and Research
- Institut National de la Santé et de la Recherche Médicale (44790)
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM081634)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK084055, R01DK084055)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- circadian clock, CD38, NAD+ hydrolase, circadian activity, locomotor activity rhythm, clock genes, amino acid metabolism, tryptophan, liver metabolome
- MeSH terms
- Animals, Behavior, Animal, Circadian Rhythm, Gene Expression Regulation, Liver, Membrane Glycoproteins, Motor Activity, Mutation, NAD, Rest, Mice, Knockout, Mice, ADP-ribosyl Cyclase 1
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