Cited by 73Diabetes, Cardiovascular Risks, and LipoproteinsCardiac electrophysiology and arrhythmiasCardiovascular Function and Risk Factors

Diabetes and the risk of sudden cardiac death, the Atherosclerosis Risk in Communities study

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Kucharska-Newton, Anna M., Couper, David J., Pankow, James S., Prineas, Ronald J., Rea, Thomas D., Sotoodehnia, Nona, Chakravarti, Aravinda, Folsom, Aaron R. +2 more·2010·Acta Diabetologica

Abstract

Studies suggest that diabetes may specifically elevate the risk of sudden cardiac death in excess of other heart disease outcomes. In this study, we examined the association of type 2 diabetes with the incidence of sudden cardiac death when compared to the incidence of non-sudden cardiac death and non-fatal myocardial infarction (MI). We used data from the Atherosclerosis Risk in Communities (ARIC) study to examine the incidence of sudden and non-sudden cardiac death and non-fatal MI among persons with and without diabetes in follow-up from the baseline data collection (1987-1989) through December 31, 2001. There were 209 cases of sudden cardiac death, 119 of non-sudden cardiac death, and 739 of non-fatal MI identified in this cohort over an average 12.4 years of follow-up. In analyses adjusted for age, race/ARIC center, gender, and smoking, the Cox proportional hazard ratio of the association of baseline diabetes was 3.77 (95% CI 2.82, 5.05) for sudden cardiac death, 3.78 (95% CI 2.57, 5.53) for non-sudden cardiac death, and 3.20 (95% CI 2.71, 3.78) for non-fatal MI. Elevated risk for each of the three outcomes associated with diabetes was independent of adjustment for measures of blood pressure, lipids, inflammation, hemostasis, and renal function. Among those with diabetes, the risk of cardiac death, but not of non-fatal MI, was similar for men and women. Findings from this prospective, population-based cohort investigation indicate that diabetes does not confer a specific excess risk of sudden cardiac death. Our results suggest that diabetes attenuates gender differences in the risk of fatal cardiac events.

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  • In a meta-analysis of 14 studies involving 346,356 participants and 5,647 sudden cardiac death cases, the risk of sudden cardiac death was two-fold higher in patients with diabetes compared with patients without diabetes (adjusted HR 2.25; 95% CI, 1.70-2.97).

    “In a meta-analysis of 14 studies involving 346 356 participants and 5647 SCD cases, the risk of SCD was two-fold higher in patients with diabetes compared with patients without diabetes (adjusted HR 2.25; 95% CI, 1.70-2.97).647”

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Authors
Kucharska-Newton, A. M., Couper, D. J., Pankow, J. S., Prineas, R. J., Rea, T. D., Sotoodehnia, N., Chakravarti, A., Folsom, A. R., Siscovick, D. S., & Rosamond, W. D.
Affiliations
  • University of North Carolina at Chapel Hill (US)
  • University of Minnesota (US)
  • Wake Forest University (US)
  • University of Washington (US)
  • Johns Hopkins University (US)
Venue
Acta Diabetologica
Published
2009-10-24
Volume
47
Issue
S1
Pages
161-168
ISSN
  • 0940-5429 (ISSN-L)
  • 1432-5233
OpenAlex
W2086313335
Cited by
73
References
29
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 10 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 4 · 2013: 3 · 2012: 2
FWCI
1.94
Type
journal article
Language
en
Open access
Locations
  • Acta Diabetologica (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (n01hc55021-47-0-1, n01hc55020-39-0-0, n01hc55016-37-0-0, n01hc055022-024, n01hc55019-35-0-1, n01hc55018-38-0-1, n01hc55015-48-0-1)
  • U.S. Public Health Service (T32 H2-0007055)
  • National Heart, Lung, and Blood Institute (N01-HC55022, N01 HC055016, N01-HC-55018, N01 HC 55020, N01 HC 55019, N01 HC055020, N01 HC055018, ­N01-HC55016, N01 HC055022, N01 HC055019, N01‐HC‐55015, N01-HC55021, N01 HC055021, N01 HC055015, T32HL007055)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
type 2 diabetes, sudden cardiac death, nonfatal myocardial infarction, sex differences in cardiovascular risk, Atherosclerosis Risk in Communities Study, diabetes and cardiovascular risk
MeSH terms
Aged, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Residence Characteristics, Risk Factors, United States, Cohort Studies, Incidence, Death, Sudden, Cardiac, Atherosclerosis

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