Diabetes and the risk of sudden cardiac death, the Atherosclerosis Risk in Communities study
Open accessAbstract
Studies suggest that diabetes may specifically elevate the risk of sudden cardiac death in excess of other heart disease outcomes. In this study, we examined the association of type 2 diabetes with the incidence of sudden cardiac death when compared to the incidence of non-sudden cardiac death and non-fatal myocardial infarction (MI). We used data from the Atherosclerosis Risk in Communities (ARIC) study to examine the incidence of sudden and non-sudden cardiac death and non-fatal MI among persons with and without diabetes in follow-up from the baseline data collection (1987-1989) through December 31, 2001. There were 209 cases of sudden cardiac death, 119 of non-sudden cardiac death, and 739 of non-fatal MI identified in this cohort over an average 12.4 years of follow-up. In analyses adjusted for age, race/ARIC center, gender, and smoking, the Cox proportional hazard ratio of the association of baseline diabetes was 3.77 (95% CI 2.82, 5.05) for sudden cardiac death, 3.78 (95% CI 2.57, 5.53) for non-sudden cardiac death, and 3.20 (95% CI 2.71, 3.78) for non-fatal MI. Elevated risk for each of the three outcomes associated with diabetes was independent of adjustment for measures of blood pressure, lipids, inflammation, hemostasis, and renal function. Among those with diabetes, the risk of cardiac death, but not of non-fatal MI, was similar for men and women. Findings from this prospective, population-based cohort investigation indicate that diabetes does not confer a specific excess risk of sudden cardiac death. Our results suggest that diabetes attenuates gender differences in the risk of fatal cardiac events.
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In a meta-analysis of 14 studies involving 346,356 participants and 5,647 sudden cardiac death cases, the risk of sudden cardiac death was two-fold higher in patients with diabetes compared with patients without diabetes (adjusted HR 2.25; 95% CI, 1.70-2.97).
“In a meta-analysis of 14 studies involving 346 356 participants and 5647 SCD cases, the risk of SCD was two-fold higher in patients with diabetes compared with patients without diabetes (adjusted HR 2.25; 95% CI, 1.70-2.97).647”
From 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes. (2023) · cites this paper as [647]
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- Authors
- Kucharska-Newton, A. M., Couper, D. J., Pankow, J. S., Prineas, R. J., Rea, T. D., Sotoodehnia, N., Chakravarti, A., Folsom, A. R., Siscovick, D. S., & Rosamond, W. D.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- University of Minnesota (US)
- Wake Forest University (US)
- University of Washington (US)
- Johns Hopkins University (US)
- ORCID
- Venue
- Acta Diabetologica
- Published
- 2009-10-24
- Volume
- 47
- Issue
- S1
- Pages
- 161-168
- ISSN
- 0940-5429 (ISSN-L)
- 1432-5233
- PMC
- PMC3064263
- OpenAlex
- W2086313335
- Cited by
- 73
- References
- 29
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 10 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 4 · 2013: 3 · 2012: 2
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Diabetologica (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc55021-47-0-1, n01hc55020-39-0-0, n01hc55016-37-0-0, n01hc055022-024, n01hc55019-35-0-1, n01hc55018-38-0-1, n01hc55015-48-0-1)
- U.S. Public Health Service (T32 H2-0007055)
- National Heart, Lung, and Blood Institute (N01-HC55022, N01 HC055016, N01-HC-55018, N01 HC 55020, N01 HC 55019, N01 HC055020, N01 HC055018, N01-HC55016, N01 HC055022, N01 HC055019, N01‐HC‐55015, N01-HC55021, N01 HC055021, N01 HC055015, T32HL007055)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- type 2 diabetes, sudden cardiac death, nonfatal myocardial infarction, sex differences in cardiovascular risk, Atherosclerosis Risk in Communities Study, diabetes and cardiovascular risk
- MeSH terms
- Aged, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Residence Characteristics, Risk Factors, United States, Cohort Studies, Incidence, Death, Sudden, Cardiac, Atherosclerosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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