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Cited by 96Pancreatic function and diabetesDiabetes and associated disordersTransplantation: Methods and Outcomes

Five-year follow-up of patients with type 1 diabetes transplanted with allogeneic islets: the UIC experience

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Qi, Meirigeng, Kinzer, Katie, Danielson, Kirstie K., Martellotto, Joan, Barbaro, Barbara, Wang, Yong, Bui, James T., Gaba, Ron C. +8 more·2014·Acta Diabetologica
DOI 10.1007/s00592-014-0627-6PMC PMC4801517
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Abstract

This report summarizes a 5-year phase 1/2 allogeneic islet transplantation clinical trial conducted at the University of Illinois at Chicago (UIC). Ten patients were enrolled in this single center, open label, and prospective trial in which patients received 1-3 transplants. The first four subjects underwent islet transplantation with the Edmonton immunosuppressive regimen and the remaining six subjects received the UIC immunosuppressive protocol (Edmonton plus etanercept and exenatide). All 10 patients achieved insulin independence after 1-3 transplants. At 5 years of follow-up, 6 of the initial 10 patients were free of exogenous insulin. During the follow-up period, 7 of the 10 patients maintained positive C-peptide levels and a composite hypoglycemic score of 0. Most patients maintained HbA1c levels <6.0 % (42.1 mmol/mol) and a significantly improved β-score. In conclusion, this study demonstrated long-term islet graft function without using T cell depleting induction, with an encouraging outcome that includes 60 % of patients remaining insulin independent after 5 years of initial transplantation.

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Cited by

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Authors
Qi, M., Kinzer, K., Danielson, K. K., Martellotto, J., Barbaro, B., Wang, Y., Bui, J. T., Gaba, R. C., Knuttinen, G., Garcia-Roca, R., Tzvetanov, I., Heitman, A., Davis, M., McGarrigle, J. J., Benedetti, E., & Oberholzer, J.
Affiliations
  • University of Illinois Chicago (US)
  • Emmes (United States) (US)
ORCID
Venue
Acta Diabetologica
Publisher
Springer Science and Business Media LLC
Published
2014-07-18
Volume
51
Issue
5
Pages
833-843
ISSN
  • 0940-5429 (ISSN-L)
  • 1432-5233
DOI
10.1007/s00592-014-0627-6
PMC
PMC4801517
OpenAlex
W1976515053
Cited by
96
References
1
Citations by year
2026: 6 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 6 · 2018: 12 · 2017: 11 · 2016: 20 · 2015: 7
FWCI
12.57
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Acta Diabetologica (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Center for Research Resources (UL1RR029879, U42RR023245)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
Keywords
type 1 diabetes, allogeneic islet transplantation, insulin independence, immunosuppression, etanercept, exenatide, C-peptide, HbA1c, hypoglycemia, islet graft function, long-term follow-up
MeSH terms
Adult, Aged, Blood Glucose, C-Peptide, Chicago, Diabetes Mellitus, Type 1, Female, Follow-Up Studies, Glycated Hemoglobin, Hospitals, University, Humans, Insulin, Male, Middle Aged, Prospective Studies, Transplantation, Homologous, Islets of Langerhans Transplantation

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