Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease

Frölich, L., Blum-Degen, D., Bernstein, H.-G., Engelsberger, S., Humrich, J., Laufer, S., Muschner, D., Thalheimer, A., Türk, A., Hoyer, S., Zöchling, R., Boissl, K. W., Jellinger, K., Riederer, P.·1998·Journal of Neural Transmission

DOI 10.1007/s007020050068

Cited by (745)

Items 301–400 of 745

Diabetes type II: A risk factor for depression-Parkinson–Alzheimer?
Riederer, Peter, Bartl, Jasmin, Laux, Gerd, Grünblatt, Edna · 2011 · Neurotoxicity Research
Impaired Insulin Signaling and Mechanisms of Memory Loss
Jenna Bloemer, Subhrajit Bhattacharya, Rajesh Amin, Vishnu D. Suppiramaniam · 2014 · Progress in molecular biology and translational science
Role of Dietary and Endogenous Antioxidants in Diabetes
Giuseppina Marrazzo, Ignazio Alberto Barbagallo, Fabio Galvano, Michele Malaguarnera, Diego Gazzolo, Alessandro Frigiola, Nicolantonio D’Orazio, Giovanni Li Volti · 2013 · Critical Reviews in Food Science and Nutrition
Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles
Yamir Islam, Andrew G. Leach, Jayden A. Smith, Stefano Pluchino, Christopher R. Coxon, Muttuswamy Sivakumaran, James R. Downing, Amos A. Fatokun, Meritxell Teixidò, Touraj Ehtezazi · 2021 · Advanced Science
Cortical glucose metabolism is altered in aged transgenic Tg2576 mice that demonstrate Alzheimer plaque pathology
Marina Bigl, Jenny Apelt, Klaus Eschrich, Reinhard Schliebs · 2003 · Journal of Neural Transmission
Proteasome‐mediated proteostasis: Novel medicinal and pharmacological strategies for diseases
Ribhav Mishra, Arun Upadhyay, Vijay Kumar Prajapati, Amit Mishra · 2018 · Medicinal Research Reviews
Characterization of Cerebral Damage in a Monkey Model of Alzheimer’s Disease Induced by Intracerebroventricular Injection of Streptozotocin
Hyeon-Gu Yeo, Youngjeon Lee, Chang‐Yeop Jeon, Kang-Jin Jeong, Yeung Bae Jin, Philyong Kang, Sun‐Uk Kim, Ji-Su Kim, Jae‐Won Huh, Younghyun Kim et al. · 2015 · Journal of Alzheimer s Disease
Therapeutic targets of brain insulin resistance in sporadic Alzheimer's disease
M Suzanne · 2011 · Frontiers in Bioscience-Elite
Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer’s disease?
Ana Knezović, Alexander Loncar, Jan Homolak, Una Smailović, Jelena Osmanović Barilar, Lana Ganoci, Nada Božina, Peter Franz Riederer, Melita Šalković‐Petrišić · 2017 · Journal of Neural Transmission
Effect of insulin and melatonin on acetylcholinesterase activity in the brain of amnesic mice
Rahul Agrawal, Ethika Tyagi, Rakesh Shukla, Chandishwar Nath · 2008 · Behavioural Brain Research
Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease
Ana Isabel Duarte, Maria S. Santos, Catarina Resende Oliveira, Paula Isabel Moreira · 2018 · Neuropharmacology
Functional Recovery of Cholinergic Basal Forebrain Neurons under Disease Conditions: Old Problems, New Solutions?
Wolfgang Härtig, Andreas Bauer, Kurt Brauer, Jens Grosche, Tibor Hortobágyi, Botond Penke, Reinhard Schliebs, Tibor Harkany · 2002 · Reviews in the Neurosciences
Diabetic neuropathy - a continuing enigma
Kazuhiro Sugimoto, Yūichi Murakawa, Anders A. F. Sima · 2000 · Diabetes/Metabolism Research and Reviews
Early Molecular Changes in Alzheimer Disease: Can We Catch the Disease in its Presymptomatic Phase?
Kerstin T.S. Wirz, Stella Keitel, Dick Frans Swaab, Joost Verhaagen, Koen Bossers · 2013 · Journal of Alzheimer s Disease
Multi-target iron-chelators improve memory loss in a rat model of sporadic Alzheimer's disease
Melita Šalković‐Petrišić, Ana Knezović, Jelena Osmanović Barilar, Una Smailović, Vladimir Trkulja, Peter Franz Riederer, Tamar Amit, Silvia A. Mandel, Moussa B. H. Youdim · 2015 · Life Sciences
Neuronal DNA damage response‐associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of A lzheimer‐type pathology
Julie E. Simpson, Paul G. Ince, Thaı́s Minett, Fiona E. Matthews, Paul Roy Heath, Pamela J. Shaw, Gerald Goodall, Claire J. Garwood, Laura E. Ratcliffe, Carol Brayne et al. · 2015 · Neuropathology and Applied Neurobiology
Insulin Receptor Signaling in Cones
Ammaji Rajala, Radhika Dighe, Martin‐Paul Agbaga, Robert E. Anderson, Raju V. S. Rajala · 2013 · Journal of Biological Chemistry
Diabetes and neurodegeneration in the brain
Cory C. Toth · 2014 · Handbook of clinical neurology
AMPK: Potential Therapeutic Target for Alzheimer's Disease
Luping Yang, Yijing Jiang, Lihong Shi, Dongling Zhong, Yuxi Li, Juan Li, Rongjiang Jin · 2019 · Current Protein and Peptide Science
Cerebrospinal fluid levels of insulin in patients with Alzheimer's disease
José Antonio Pérez-Molina, F J Jiménez-Jiménez, C. Vargas, Pedro Antonio Gómez, Fernando de Bustos, Carlos Gómez-Escalonilla, Martín Zurdo, A. Tallón-Barranco, Antonio Martínez‐Salio, Jesús Porta-Etessam et al. · 2002 · Acta Neurologica Scandinavica
Hyperphosphorylation of Tau Protein in Hippocampus of Central Insulin-Resistant Rats is Associated with Cognitive Impairment
Dantao Peng, Xiuqing Pan, Ju Cui, Yueqin Ren, Jiewen Zhang · 2013 · Cellular Physiology and Biochemistry
Amyloid-β Protein Modulates Insulin Signaling in Presynaptic Terminals
David Heras-Sandoval, Patricia Ferrera, Clorinda Arias · 2012 · Neurochemical Research
Targeting insulin-like growth factor-1 to treat Alzheimer's disease
Ignacio Torres‐Alemán · 2007 · Expert Opinion on Therapeutic Targets
A Potential Role of Central Insulin in Learning and Memory Related to Feeding
Kyriaki Gerozissis, Claude Rouch, Stéphanie Lemierre, Stylianos Nicolaı̈dis, Martine Orosco · 2001 · Cellular and Molecular Neurobiology
Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease
Danae Liolitsa · 2002 · Journal of Neurology Neurosurgery & Psychiatry
Intranasal insulin: From nose to brain
Robert Irwin Henkin · 2009 · Nutrition
Patients with chronic kidney disease are at an elevated risk of dementia: A population-based cohort study in Taiwan
K. F. Cheng, Yu‐Lung Chen, Shih‐Wei Lai, Chih-Hsin Mou, Pang‐Yao Tsai, Fung‐Chang Sung · 2012 · BMC Nephrology
The metabolism hypothesis of Alzheimer’s disease: from the concept of central insulin resistance and associated consequences to insulin therapy
Katrin Morgen, Lutz Frölich · 2015 · Journal of Neural Transmission
Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer’s Disease Pathology and Shows Differential Expression in Transgenic Mice
Luke W. Bonham, Ethan G. Geier, Natasha Z. R. Steele, Dominic Holland, Bruce L. Miller, Anders Martin Dale, Rahul S. Desikan, Jennifer S. Yokoyama, Alzheimer’s Disease Neuroimaging Initiative · 2018 · Frontiers in Neuroscience
Routes for the delivery of insulin to the central nervous system: A comparative review
Rhea, Elizabeth M., Salameh, Therese S., Banks, William A. · 2019 · Experimental Neurology
Neurochemical characterization of insulin receptor‐expressing primary sensory neurons in wild‐type and vanilloid type 1 transient receptor potential receptor knockout mice
Djalil Baiou, Péter Sántha, António Avelino, Ana Charrua, Tímea Bácskai, Klára Matesz, Francisco Cruz, I. Nagy · 2007 · The Journal of Comparative Neurology
Metabolic determinants of Alzheimer’s disease: A focus on thermoregulation
Marine Tournissac, Manon Leclerc, Josue Valentin‐Escalera, Milène Vandal, Cristina R. Bosoi, Emmanuel Planel, Frédéric Calon · 2021 · Ageing Research Reviews
Molecular mechanisms linking type 2 diabetes mellitus and late-onset Alzheimer's disease: A systematic review and qualitative meta-analysis
Erwin Lemche, Richard Killick, Jackie Mitchell, Paul Caton, Pratik Choudhary, Jane K. Howard · 2024 · Neurobiology of Disease
Age‐associated cholesterol reduction triggers brain insulin resistance by facilitating ligand‐independent receptor activation and pathway desensitization
Adrián Martín‐Segura, Tariq Ahmed, Álvaro Casadomé‐Perales, Irene Palomares-Pérez, Ernest Palomer, Axelle Kerstens, Sebastian Munck, Detlef Balschun, Carlos G. Dotti · 2019 · Aging Cell
Exposure of ultrafine particulate matter causes glutathione redox imbalance in the hippocampus: A neurometabolic susceptibility to Alzheimer's pathology
Soo Jin Park, Jimin Lee, Seung-Hoon Lee, Sangchul Lim, Juhwan Noh, So Yeon Cho, Jung-Hee Ha, Hyunjeong Kim, Changsoo Kim, Sunho Park et al. · 2020 · The Science of The Total Environment
Social Aspects of Dementia Prevention from a Worldwide to National Perspective: A Review on the International Situation and the Example of Italy
Giovanna Ricci · 2019 · Behavioural Neurology
Insulin-induced expression of the activity-regulated cytoskeleton-associated gene (ARC) in human neuroblastoma cells requires p21ras, mitogen-activated protein kinase/extracellular regulated kinase and src tyrosine kinases but is protein kinase C-independent
Joachim Kremerskothen, Doreen Wendholt, Iskender Teber, Angelika Barnekow · 2002 · Neuroscience Letters
ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer’s disease mouse model
Chan, Elizabeth S., Shetty, Mahesh Shivarama, Sajikumar, Sreedharan, Chen, Christopher, Soong, Tuck Wah, Wong, Boon-Seng · 2016 · Scientific Reports
The Expression of Insulin in the Central Nervous System: What Have We Learned So Far?
Tamara B. Dakic, Tanja V. Jevdjovic, Iva V. Lakic, Aleksandra Ružičić, Nebojsa I. Jasnic, Sinisa F. Djurasevic, Jelena D. Djordjevic, Predrag Z. Vujovic · 2023 · International Journal of Molecular Sciences
Chronic acarbose treatment alleviates age-related behavioral and biochemical changes in SAMP8 mice
Jing‐Jing Tong, Gui-Hai Chen, Fang Wang, Xuewei Li, Lei Cao, Xu Sui, Fei Tao, Wen-Wen Yan, Zhao‐Jun Wei · 2015 · Behavioural Brain Research
A photonic crystal based sensing scheme for acetylcholine and acetylcholinesterase inhibitors
Christoph Fenzl, Christa Genslein, Alexander Zöpfl, Antje J. Baeumner, Thomas Hirsch · 2015 · Journal of Materials Chemistry B
Brain insulin resistance impairs hippocampal plasticity
Matteo Spinelli, Salvatore Fusco, Claudio Grassi · 2020 · Vitamins and hormones
Trimethylamine N-oxide (TMAO) drives insulin resistance and cognitive deficiencies in a senescence accelerated mouse model
María Lanz, Manuel H. Janeiro, Fermin Ignacio Milagro, Elena Puerta, Iziar A. Ludwig, Antonio Pineda‐Lucena, María Javier Ramírez, Maite Solas · 2022 · Mechanisms of Ageing and Development
Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses
Suélen Santos Alves, Rui Milton Patrício da Silva-Júnior, Gabriel Servilha‐Menezes, Jan Homolak, Melita Šalković‐Petrišić, Norberto Garcia‐Cairasco · 2021 · Journal of Alzheimer s Disease
The Negative Effects of Obesity and Poor Glycemic Control on Cognitive Function: A Proposed Model for Possible Mechanisms
Michael Louis Alosco, John Gunstad · 2014 · Current Diabetes Reports
Wilms’ tumor suppressor (WT1) is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer’s disease
Mark A. Lovell, Chengsong Xie, Shuling Xiong, William R. Markesbery · 2003 · Brain Research
Insulin receptors in the brain cortex of aging mice
Annamaria Zaia, LUCIO PIANTANELLI · 2000 · Mechanisms of Ageing and Development
Effects of Intranasal Insulin Administration on Cerebral Blood Flow and Cognitive Performance in Adults: A Systematic Review of Randomized, Placebo-Controlled Intervention Studies
Kevin M.R. Nijssen, Ronald P. Mensink, Peter J. Joris · 2022 · Neuroendocrinology
Metabolic aspects of neuronal degeneration: From a NAD+ point of view
Yo Sasaki · 2018 · Neuroscience Research
Pharmacological Interventions to Attenuate Alzheimer’s Disease Progression: The Story So Far
Firas H. Bazzari, Dalaal M. Abdallah, Hanan Salah El-Abhar · 2019 · Current Alzheimer Research
Understanding the link between insulin resistance and Alzheimer’s disease: Insights from animal models
Natalia M. Lyra e Silva, Rafaella Araujo Gonçalves, Susan E. Boehnke, Letícia Forny‐Germano, Douglas P. Munoz, Fernanda G. De Felice · 2019 · Experimental Neurology
Intranasal insulin and orexins to treat age-related cognitive decline
Jennifer M. Erichsen, Coleman B. Calva, Lawrence Patrick Reagan, Jim R. Fadel · 2021 · Physiology & Behavior
Metabolic Syndrome: Is It Time to Add the Central Nervous System?
Milagros Rojas, Mervin Chávez-Castillo, Daniela Pírela, Heliana Parra, Manuel Nava, Maricarmen Chacín, Lissé Angarita, Roberto Áñez, Juan José Salazar, Rina Ortíz et al. · 2021 · Nutrients
Effects of treadmill exercise on brain insulin signaling and β-amyloid in intracerebroventricular streptozotocin induced-memory impairment in rats
Eun‐Bum Kang, Joon Yong Cho · 2014 · Physical Activity and Nutrition
In vivo imaging of insulin receptors by PET: preclinical evaluation of iodine-125 and iodine-124 labelled human insulin
Patricia Iozzo, S. Osman, Matthias Glaser, Markus Knickmeier, Ele Ferrannini, Victor William Pike, Paolo Guido Camici, Marilyn P. Law · 2002 · Nuclear Medicine and Biology
Enhanced Retinal Insulin Receptor-activated Neuroprotective Survival Signal in Mice Lacking the Protein-tyrosine Phosphatase-1B Gene
Raju V. S. Rajala, Masaki Tanito, Benjamin G. Neel, Ammaji Rajala · 2010 · Journal of Biological Chemistry
Effects of insulin-like growth factor 1 on synaptic excitability in cultured rat hippocampal neurons
Chunxiao Xing, Y YIN, R CHANG, X GONG, Ximin He, Zhiping Xie · 2007 · Experimental Neurology
Actions and interactions of the IGF system in Alzheimer’s disease: review and hypotheses
Brett R. Lackey, Sandra L. Gray, Donald M. Henricks · 2000 · Growth Hormone & IGF Research
Challenges of Repurposing Tetracyclines for the Treatment of Alzheimer’s and Parkinson’s Disease
Markulin, Iva, Matasin, Marija, Turk, Viktorija Erdeljic, Salković-Petrisic, Melita · 2022 · Journal of Neural Transmission
Cognitive Impairment and Diabetes
Sandip K. Dash · 2013 · Recent Patents on Endocrine Metabolic & Immune Drug Discovery
Memory enhancing actions of Asiasari radix extracts via activation of insulin receptor and extracellular signal regulated kinase (ERK) I/II in rat hippocampus
Yong Chol Han, Sung‐Jin Kim · 2003 · Brain Research
Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer’s disease pathogenesis
Wu, Zhourui, Chen, Chun, Kang, Seong Su, Liu, Xia, Gu, Xiaohuan, Yu, Shan Ping, Keene, C Dirk, Cheng, Liming, Ye, Keqiang · 2021 · Proceedings of the National Academy of Sciences
Cannabinoid Receptor Type 1 Agonist ACEA Improves Cognitive Deficit on STZ-Induced Neurotoxicity Through Apoptosis Pathway and NO Modulation
Fernanda Crunfli, Talita Aparecida de Moraes Vrechi, Andressa Pereira Costa, Andréa da Silva Torrão · 2019 · Neurotoxicity Research
Genome-wide profiling and predicted significance of post-mortem brain microRNA in Alzheimer’s disease
Adriane Dallanora Henriques, Wilcelly Machado‐Silva, Renata Elaine Paraízo Leite, Cláudia Kimie Suemoto, Kátia Ramos Moreira Leite, Miguel Srougi, Alexandre C. Pereira, Wilson Jacob Filho, Otávio de Tolêdo Nóbrega · 2020 · Mechanisms of Ageing and Development
Chronic nicotine attenuates behavioral and synaptic plasticity impairments in a streptozotocin model of Alzheimer’s disease
Ingrid M. Esteves, Cleiton Lopes‐Aguiar, Matheus Teixeira Rossignoli, Rafael Naime Ruggiero, Ana Clara Broggini, Lézio Soares Bueno-Júnior, Ludmyla Kandratavicius, M.R. Monteiro, Rodrigo Neves Romcy-Pereira, João Pereira Leite · 2017 · Neuroscience
The Role of Insulin Resistance and Protein O-GlcNAcylation in Neurodegeneration
Suraiya Anjum Ansari, Bright Starling Emerald · 2019 · Frontiers in Neuroscience
H2O2 Signalling Pathway: A Possible Bridge between Insulin Receptor and Mitochondria
Помыткин Игорь Анатольевич · 2012 · Current Neuropharmacology
Impact of Single or Repeated Dose Intranasal Zinc-free Insulin in Young and Aged F344 Rats on Cognition, Signaling, and Brain Metabolism
Katie L. Anderson, Hilaree N. Frazier, Shaniya Maimaiti, Vikas Bakshi, Zana R. Majeed, Lawrence D. Brewer, Nada M. Porter, Ai‐Ling Lin, Olivier Thibault · 2016 · The Journals of Gerontology Series A
The Effect of Intrahippocampal Insulin Infusion on Spatial Cognitive Function and Markers of Neuroinflammation in Diet-induced Obesity
Joanne M. Gladding, Kirsten N. Abbott, Christopher P. Antoniadis, Angela Stuart, Denovan P. Begg · 2018 · Frontiers in Endocrinology
Tau Cleavage Contributes to Cognitive Dysfunction in Strepto-Zotocin-Induced Sporadic Alzheimer’s Disease (sAD) Mouse Model
Valentina Latina, Giacomo Giacovazzo, Pietro Calissano, Anna Atlante, Federico La Regina, Francesca Malerba, Marco Dell’Aquila, Egidio Stigliano, Bijorn Omar Balzamino, Alessandra Micera et al. · 2021 · International Journal of Molecular Sciences
Beta-Amyloid Monomer and Insulin/IGF-1 Signaling in Alzheimer's Disease
Maria Laura Giuffrida, Marianna Flora Tomasello, Filippo Caraci, Santina Chiechio, Ferdinando Nicoletti, Agata Copani · 2012 · Molecular Neurobiology
Consequences of Aberrant Insulin Regulation in the Brain: Can Treating Diabetes be Effective for Alzheimers Disease
Leila Arab, Ramin Sadeghi, Douglas G. Walker, L-F Lue, Marwan Noel Sabbagh · 2011 · Current Neuropharmacology
Axonal and Dendritic Changes are Associated with Diabetic Encephalopathy in Rats: An Important Risk Factor for Alzheimer's Disease
Yanping Zhou, Yi Luo, Jiapei Dai · 2013 · Journal of Alzheimer s Disease
Amylin Receptor: A Common Pathophysiological Target in Alzheimer’s Disease and Diabetes Mellitus
Wen Fu, Aarti Patel, Jack H. Jhamandas · 2013 · Frontiers in Aging Neuroscience
Metformin and Its Sulfenamide Prodrugs Inhibit Human Cholinesterase Activity
Markowicz-Piasecka, Magdalena, Sikora, Joanna, Mateusiak, Łukasz, Mikiciuk-Olasik, Elżbieta, Huttunen, Kristiina M. · 2017 · Oxidative Medicine and Cellular Longevity
Thiazolidinediones: novel treatments for cognitive deficits in mood disorders?
McIntyre, Roger S, Soczynska, Joanna K, Woldeyohannes, Hanna O, Lewis, Gary F, Leiter, Lawrence A, MacQueen, Glenda M, Miranda, Andrew, Fulgosi, Don, Konarski, Jakub Z, Kennedy, Sidney H · 2007 · Expert Opinion on Pharmacotherapy
Loss of insulin signaling in microglia impairs cellular uptake of Aβ and neuroinflammatory response exacerbating AD-like neuropathology
Wenqiang Chen, Xiangyu Liu, Vítor Rosetto Muñoz, C. Ronald Kahn · 2025 · Proceedings of the National Academy of Sciences
Caffeine, Diabetes, Cognition, and Dementia
Geert Jan Biessels · 2010 · Journal of Alzheimer s Disease
Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25–35)-induced amnesia
Zinaida I. Storozheva, Andrey T. Proshin, Vladimir V. Sherstnev, Tatiana P. Storozhevykh, Ya. E. Senilova, Персиянцева Надежда Александровна, Vsevolod G. Pinelis, Н. А. Семенова, Elena I. Zakharova, Помыткин Игорь Анатольевич · 2008 · BMC Pharmacology
The Role of Insulin and Insulin-Like Growth Factor-1/FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia
Lorna Moll, M Schubert · 2012 · Current Gerontology and Geriatrics Research
Differential effects of blood insulin and HbA1c on cerebral amyloid burden and neurodegeneration in nondiabetic cognitively normal older adults
Min Soo Byun, Hyun Jung Kim, Dahyun Yi, Hyo Jung Choi, Hyewon Baek, Jun Ho Lee, Young Min Choe, Bo Kyung Sohn, Jun‐Young Lee, Younghwa Lee et al. · 2017 · Neurobiology of Aging
Revisiting the Role of Insulin-Like Growth Factor-I Receptor Stimulating Activity and the Apolipoprotein E in Alzheimer’s Disease
Sara A. Galle, Ashley van der Spek, Madeleine L. Drent, Michael P. Brugts, Erik Scherder, J. A. M. J. L. Janssen, M. Arfan Ikram, Cornelia M. van Duijn · 2019 · Frontiers in Aging Neuroscience
Focus on the Correlations between Alzheimer’s Disease and Type 2 Diabetes
Vincenzo Fiore, Antonia De Rosa, Paolo Falasca, Massimo Marci, Edoardo Guastamacchia, Brunella Licchelli, Vito Angelo Giagulli, Giovanni De Pergola, Antonella Poggi, Vincenzo Triggiani · 2019 · Endocrine Metabolic & Immune Disorders - Drug Targets
Infection and Immunometabolism in the Central Nervous System: A Possible Mechanistic Link Between Metabolic Imbalance and Dementia
Noriko Shinjyo, Kiyoshi Kita · 2021 · Frontiers in Cellular Neuroscience
Wnt3a upregulates brain-derived insulin by increasing NeuroD1 via Wnt/β-catenin signaling in the hypothalamus
Jaemeun Lee, Kyungchan Kim, Seong-Woon Yu, Eun Kyoung Kim · 2016 · Molecular Brain
Synopsis on the Linkage of Alzheimer's and Parkinson's Disease with Chronic Diseases
Nasimudeen R. Jabir, Chelapram K. Firoz, Saleh Salem Baeesa, Ghulam Md Ashraf, Suhail Akhtar, Warda Kamal, Mohammad Amjad Kamal, Shams S. M. Tabrez · 2014 · CNS Neuroscience & Therapeutics
Antidiabetic therapies and Alzheimer disease.
Barbara B. Bendlin · 2019 · PubMed Central
Insulin resistance in Alzheimer disease: Is heme oxygenase-1 an Achille's heel?
Eugenio Barone, David Allan Butterfield · 2015 · Neurobiology of Disease
Mechanisms of Aβ Clearance and Catabolism
Suzanne Y. Guénette · 2003 · NeuroMolecular Medicine
Osteoporosis and Alzheimer´s disease (or Alzheimer´s disease and Osteoporosis)
Nahuel Ezequiel Wanionok, Gustavo R. Morel, Juan Manuel Fernández · 2024 · Ageing Research Reviews
Effect of insulin on spatial memory in aluminum chloride-induced dementia in rats
Madhavan Nampoothiri, Nitesh Kumar, Grandhi Venkata Ramalingayya, Nampurath Gopalan Kutty, Krishnadas Nandakumar, C. Mallikarjuna Rao · 2017 · Neuroreport
Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice
Chan, Elizabeth S, Chen, Christopher, Cole, Gregory M, Wong, Boon-Seng · 2015 · Scientific Reports
PEGylation enhances the therapeutic potential for insulin-like growth factor I in central nervous system disorders
Stefanie Saenger, Celia Goeldner, Johann Rudolf Frey, Laurence Ozmen, Susanne Ostrowitzki, Will P. J. M. Spooren, Theresa M. Ballard, E. P. M. Prinssen, Edilio Borroni, Friedrich Metzger · 2011 · Growth Hormone & IGF Research
How Do Periodontal Infections Affect the Onset and Progression of Alzheimer’s Disease?
Munvar Miya Shaik, Sultan Ahmad, Siew Hua Gan, Adel Mohammed Abuzenadah, Ejaz Ahmad, Shams S. M. Tabrez, Farid Ahmed, Mohammad Amjad Kamal · 2014 · CNS & Neurological Disorders - Drug Targets
Novel calcium-related targets of insulin in hippocampal neurons
Shaniya Maimaiti, Hilaree N. Frazier, Katie L. Anderson, Adam O. Ghoweri, Lawrence D. Brewer, Nada M. Porter, Olivier Thibault · 2017 · Neuroscience
Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1–40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease
Mini P. Sajan, BARBARA CALEEN HANSEN, Margaret G. Higgs, C. Ronald Kahn, Ursula Braun, Michael Leitges, Collin R. Park, David M. Diamond, Robert V. Farese · 2017 · Neurobiology of Aging
[1-13C]Glucose entry in neuronal and astrocytic intermediary metabolism of aged rats
Alfredo Miccheli, Caterina Puccetti, Giorgio Capuani, Maria Enrica Di Cocco, Luciana Giardino, Laura Calzà, Angelo Battaglia, Leontino Battistin, Filippo Conti · 2003 · Brain Research
The Phosphatidylinositol 3-Kinase/mTor Pathway as a Therapeutic Target for Brain Aging and Neurodegeneration
David Heras-Sandoval, Evangelina Ávila-Muñoz, Clorinda Arias · 2011 · Pharmaceuticals
Cerebrovascular Assessment for the Risk Prediction of Alzheimer's Disease
Mauro Silvestrini, Giovanna Viticchi, Claudia Altamura, Simona Luzzi, Clotilde Balucani, Fabrizio Vernieri · 2012 · Journal of Alzheimer s Disease
Huperzine A ameliorates obesity-related cognitive performance impairments involving neuronal insulin signaling pathway in mice
Hongying Wang, Min Wu, Jun-ling Diao, Jibin Li, Yuxiang Sun, Xiaoqiu Xiao · 2019 · Acta Pharmacologica Sinica