Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease

Frölich, L., Blum-Degen, D., Bernstein, H.-G., Engelsberger, S., Humrich, J., Laufer, S., Muschner, D., Thalheimer, A., Türk, A., Hoyer, S., Zöchling, R., Boissl, K. W., Jellinger, K., Riederer, P.·1998·Journal of Neural Transmission
DOI 10.1007/s007020050068

Cited by (745)

Items 601–700 of 745

  1. Therapeutic Effects of Neuro-Cells on Amyloid Pathology, BDNF Levels, and Insulin Signalling in APPswe/PSd1E9 Mice
    Johannes de Munter, Andrey Tsoy, Kseniia Sitdikova, Erik Ch. Wolters, Kirill Chaprov, Konstantin B. Yenkoyan, Hamlet Torosyan, Sholpan Askarova, Daniel C. Anthony, Tatyana V. Strekalova · 2025 · Cells
  2. Effect of a single exercise bout on fasting cerebral blood flow and brain insulin sensitivity in middle‐aged to older adults
    Steven K. Malin, Ankit M. Shah, Michal S. Berri, David Harold Zald, Daniel J. Battillo · 2025 · Experimental Physiology
  3. Is Alzheimers disease, type 3 diabetes?
    Oytun Erbaş · 2015 · Istanbul Bilim University Florence Nightingale Journal of Medicine
  4. Type 2 Diabetes, Obesity, and Risk for Dementia: Recent Insights into Brain Insulin Resistance and Hypometabolism
    Christina E. Hugenschmidt · 2016 · Current Behavioral Neuroscience Reports
  5. Cognitive Impairment and the Diabetic Brain
    K. A. Jellinger · 2015 · International Journal of Neurology and Neurotherapy
  6. Hypothalamic insulin expression remains unaltered after short-term fasting in female rats
    Tamara B. Dakic, Milica B. Markelic, Aleksandra Ružičić, Tanja V. Jevdjovic, Iva V. Lakic, Jelena D. Djordjevic, Predrag Z. Vujovic · 2022 · Endocrine
  7. Dietary restriction alters insulin signaling pathway in the brain
    Smilja T Todorovic, Valentina Simeunovic, Milica Prvulović, Tamara B. Dakic, Tanja V. Jevdjovic, Srdjan J. Sokanovic, Selma Kanazir, Aleksandra Mladenović · 2023 · BioFactors
  8. Effect of intrahippocampal CA1 injection of insulin on spatial learning and memory deficits in diabetic rats
    Golbarg Ghiasi, Amir Farshchi, Ali Pourmotabbed, Gholamreza Bahrami, Sayyed-Ershad Nedaee · 2011 · Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Kirmānshāh
  9. Alzheimer’s Disease and Type 2 Diabetes: Different Pathologies and Same Features
    Marta Di, Pasquale Picone, Rita Carrotta, Daniela Giacomazza, P.L. San · 2011 · InTech eBooks
  10. What Protects Patients with Schizophrenia from Developing Alzheimer Pathology?
    Hans‐Gert Bernstein, Theresia Ernst, Uwe Lendeckel, Henrik Dobrowolny, Johann Steiner, Bernhard Bogerts · 2010 · Springer eBooks
  11. The Influence of Aging in the Insulin-Signaling System in Rat Exocrine Glands
    Eduardo Melani Rocha, Carla Roberta de Oliveira Carvalho, Mário J.A. Saad, Licio Augusto Velloso · 2002 · Advances in experimental medicine and biology
  12. Nutrition and Dementia
    Fabio Coppedè, Paolo Bosco, Andrea Fuso, Aron M. Troen · 2012 · Current Gerontology and Geriatrics Research
  13. Metabolic Syndrome as a Risk Factor for Alzheimer Disease
    A. A. Farooqui · 2013 · Springer eBooks
  14. Editorial: Siegfried Hoyer’s concept of Alzheimer pathophysiology
    Lutz Frölich, Walter E. Müller, Peter Franz Riederer · 2015 · Journal of Neural Transmission
  15. The Relationship Between the Continuum of Elevated Adiposity, Hyperinsulinemia, and Type 2 Diabetes and Late-onset Alzheimer’s Disease: An Epidemiological Perspective
    Luchsinger, José A. · 2010 · Research and Perspectives in Alzheimer's Disease
  16. A new approach for treating AD: Guifu Dihuang Pills improves brain insulin resistance by promoting NrCAM to activate the EGFR/PI3K/Akt signaling pathway
    Chenshi Yu, Liu Liu, Zhijian Lu, Minxia Chen, Na Yang, Zongyuan Li, Luowen Bai, Changyu Li, Xiaojie Zhou · 2025 · Journal of Ethnopharmacology
  17. The role of microbiota modulation in preventing Alzheimer’s disease- a review
    Anna Strzępa, Marian Szczepanik · 2025 · Pharmacological Reports
  18. PKC and Insulin Pathways in Memory Storage: Targets for Synaptogenesis, Anti-apoptosis, and the Treatment of AD
    Miao‐Kun Sun, Thomas J. Nelson, Daniel L. Alkon · 2010 · Research and perspectives in Alzheimer's disease
  19. Cerebrospinal fluid soluble insulin receptor levels in Alzheimer's disease
    Peter Thomas, Manon Leclerc, Kira M. Evitts, Caitlin Brown, Wyatt Miller, Angela J. Hanson, William A. Banks, Laura E. Gibbons, Kimiko Domoto‐Reilly, Suman Jayadev et al. · 2024 · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
  20. Long-range repression by ecdysone receptor on complex enhancers of the insulin receptor gene
    Katie D. Thompson, Will Suber, Rachel Nicholas, David N. Arnosti · 2023 · Fly
  21. The Effects of Blood Sugar (Glucose) Metabolism on the Sleep and Memory in Ahwaz Diabetic Patients
    Alireza Heideri, Farah Naderi, Gholamreza Pasha, Hajieh Bibi Shahbazian, Ali Kha- Lafi · 2008 · Journal of Applied Sciences
  22. Proinsulin C-peptide activates vagus efferent output in rats
    Kazuhiro Kimura, Akira Niijima, R. Yoshida, T. Kitamura, Akihiro Kamikawa, Daniela Tomie Furuya, Naoki Kitamura, A Konno, H. Nakamoto, Naoki Sakane et al. · 2005 · Peptides
  23. Is there a role fordiet in cognitive rehabilitation?
    Matthew D. Parrott, Carol E. Greenwood · 2008 · Cambridge University Press eBooks
  24. High‐Performance Liquid Chromatographic Analysis of Psychotropic and Endogenous Compounds
    John Odontiadis, Gail A. Rauw · 2006 · Springer eBooks
  25. Pathophysiological features in the brains of female Spontaneously Diabetic Torii (SDT) fatty rats
    Tatsuya Maekawa, Miki Sugimoto, Shinichi KUME, Takeshi Ohta · 2022 · Journal of Veterinary Medical Science
  26. Insulin Resistance Alzheimer's Disease: Pathophysiology and Treatment
    G. Stennis Watson, Suzanne Craft · 2007 · Progress in Neurotherapeutics and Neuropsychopharmacology
  27. Analysis of insulin receptor function in the central nervous system by conditional inactivation of its gene in mice
    Dinesh Gautam · 2002 · Kölner Universitäts PublikationsServer (Universität zu Köln)
  28. Bedingungen der Erhaltung und Förderung von Selbst- ständigkeit im höheren Lebensalter (SIMA)
    R. Rupprecht, Wolf D. Oswald, Bernd Hagen, Klaus-Christian Steinwachs · 2003 · Zeitschrift für Gerontopsychologie & -psychiatrie
  29. Insulin signaling disruption exacerbates memory impairment and seizure susceptibility in an epilepsy model with Alzheimer’s disease-like pathology
    Suélen Santos Alves, Gabriel Servilha‐Menezes, Letícia Rossi, José Antônio Cortes de Oliveira, Mariana Grigório-de-Sant’Ana, Adriano Silva Sebollela, Rui Milton Patrício da Silva-Júnior, Norberto Garcia‐Cairasco · 2025 · Journal of Neural Transmission
  30. Central cytometabolic functional vascular coupling in health and disease
    Sophiya L. Sims, Ting‐Hsuan Lu, Blaine E. Weiss, Ruei‐Lung Lin, Léopoldine B. Galopin, Nicholas A. Wright, Christopher M. Norris, Olivier Thibault · 2025 · npj Metabolic Health and Disease
  31. Revitalizing GIP: Therapeutic Potential in Metabolic and Neurodegenerative Disorders
    Yingdan Qiao, Fen Zhou, Tuohua Mao, Ling Gao · 2026 · Diabetes Metabolic Syndrome and Obesity
  32. Sex differences in brain glucose metabolism and Alzheimer's disease risk and progression
    Marjan Ramezan, Aphrodite Demetriou, Sara N. Burke, Ivan Nalvarte, Andrew Changhun Shin · 2026 · Alzheimer s & Dementia
  33. Variable bioenergetic sensitivity of neurons and astrocytes to insulin and extracellular glucose
    Sophiya L. Sims, Hilaree N. Frazier, Sami L. Case, Ruei‐Lung Lin, James N. Trosper, Hemendra J. Vekaria, Patrick G. Sullivan, Olivier Thibault · 2024 · npj Metabolic Health and Disease
  34. Relationship between Alzheimer's Disease and Type 2 Diabetes: Critical Review On Cellular and Molecular Common Pathogenic Mechanisms
    Arantxa Rodríguez‐Casado, María‐Isabel Álvarez, Jose Joaquín Merino, A. Tolédano, A. Tolédano · 2025 · Current Alzheimer Research
  35. Intranasal insulin for the treatment of alcohol use disorder: design and methodology of an alcohol interaction randomized controlled trial
    Carolina L. Haass‐Koffler, Bhavani Kashyap, Brian J. Gully, Sithara S. Nambiar, Rivkah Hornbacher, Stephanie L. Foster, Yuval Silberman, Robert M. Swift, Leah R. Hanson, William H. Frey · 2025 · Contemporary Clinical Trials Communications
  36. Diabetes Mellitus and Neurocognitive Dysfunction
    Christopher M. Ryan · 2009 · Elsevier eBooks
  37. Role of Central Insulin-Like Growth Factor-1 Receptor Signalling in Ageing and Endocrine Regulation
    Lorna Moll, Johanna Zemva, M Schubert · 2011 · InTech eBooks
  38. Fight against Glucose Rescues Age-Related Cognitive Decline
    2016 · Neuroscience Communications
  39. Genomic Linkage Between Alzheimer's Disease and Type 2 Diabetes
    Taoufik Nedjadi, Absarul Haque, Qamre Alam, Siew Hua Gan, Adeel Chaudhary, Adel Mohammed Abuzenadah, Ghazi A. Damanhouri, Mohammad Amjad Kamal · 2014 · CNS & Neurological Disorders - Drug Targets
  40. Insulin receptors in mouse brain: Reversibility of age-related impairments by a thymic extract
    Annamaria Zaia, LUCIO PIANTANELLI · 2000 · AGE
  41. The Contribution of the Amyloid Hypothesis to the Understanding of Alzheimer's Disease: A Critical Overview
    Laura Morelli, George L. Perry, Fabrizio Tagliavini · 2012 · International Journal of Alzheimer s Disease
  42. The Amyloid _-Protein and Alzheimer's Disease
    David B. Teplow, Mingfeng Yang, Robin Roychaudhuri, Eric S. Pang, Tien‐Phat V. Huynh, Mei‐Sha Chen, Shiela Beroukhim · 2012 · Frontiers in neuroscience
  43. Dementia: The Significance of Cerebral Metabolic Disturbances in Alzheimer's Disease. Relation to Parkinson's Disease
    Siegfried Hoyer, Lutz Frölich · 2007 · Springer eBooks
  44. Pathophysiological abnormalities in the brains of Spontaneously Diabetic Torii-Lepr fa (SDT fatty) rats, a novel type 2 diabetic model
    Tatsuya Maekawa, Takeshi Ohta, Shinichi KUME · 2018 · Journal of Veterinary Medical Science
  45. Diabetes and the Nervous System
    Aaron I. Vinik, CAROLINA M. CASELLINI, Serina Neuman · 2018 · Endocrinology
  46. Prospective of managing impaired brain insulin signalling in late onset Alzheimers disease with excisting diabetic drugs
    Gifty M. Jojo, Gowthamarajan Kuppusamy, Kousalya Selvaraj, Uday Krishna Baruah · 2019 · Journal of Diabetes & Metabolic Disorders
  47. Postprandial Metabolic Responses to Macronutrient in Healthy, Hyperinsulinemic and Type 2 Diabetic Subjects
    Xiaomiao Lan‐Pidhainy · 2012 · TSpace (University of Toronto)
  48. Glucose Metabolism and Insulin Action in Alzheimer’s Disease Pathogenesis
    Domenico Bosco, Massimiliano Plastino, Antonio Lorenzo Spano, Caterina Ermio, Antonietta Fav · 2011 · InTech eBooks
  49. Effect of Diabetes on Dementia and Its Preventive Strategies
    Soo‐Kyung Kim · 2012 · Journal of Korean Diabetes
  50. The Role of Insulin Resistance in Age-Related Cognitive Decline and Dementia
    G. Stennis Watson, Suzanne Craft · 2009 · Humana Press eBooks
  51. Experimental approach to Alzheimer's disease
    Melita Šalković‐Petrišić, Siegfried Hoyer, Peter Franz Riederer · 2013
  52. Univ.- Prof. Dr. med. Siegfried Hoyer 1933–2014
    Riederer Pf · 2014 · Journal of Neural Transmission
  53. Experimental Approach to Alzheimer Disease
    M. Salkovic-Petrisic, Siegfried Hoyer, Peter Franz Riederer · 2014 · Springer eBooks
  54. Therapeutic Potential of Phytochemicals: Lessons Learned from Streptozotocin-Induced Sporadic Alzheimer’s Disease
    Hayate Javed, Shreesh Kumar Ojha · 2022 · Springer eBooks
  55. Role of Impaired Insulin Signaling in the Pathogenesis of Dementia
    Abhilasha Ahlawat, Vaibhav Walia, Munish Garg · 2022 · Springer eBooks
  56. An insight into the importance of B vitamins and melatonin in the prevention of diabetes through modulation of the brain energy metabolism- a comprehensive review
    Manisha Mukhopadhyay, Priyanka Ghosh, Aindrila Chattopadhyay, Debasish Bandyopadhyay · 2023 · Melatonin Research
  57. Insulin Ameliorates Neurodegeneration in an Experimental Animal Model of Brain Aging by a Decrease of GFAP Expression and Apoptosis Inhibition
    Parnian Eslahi, Mohammad Amin Tofighi Zavareh, Mohammad Hossein K Godaneh, Abbas Aliaghaei, Mohammad Ali Asghari, Ali Asghar Payvandi, Ali Younesi, Mohammad Mahdi Gheibi, Mohammadamin Sabbagh Alvani, Fatemeh Fadaei Fatabadi et al. · 2024 · Journal of Cellular & Molecular Anesthesia
  58. The Relationship Between Diabetes and Alzheimer's Disease
    İnci Kazkayası, Nihan BURUL BOZKURT, Serdar Uma · 2018 · Journal of Literature Pharmacy Sciences
  59. Diabetes and the Nervous System
    Aaron I. Vinik, CAROLINA M. CASELLINI, Serina A. Neumann · 2018 · Endocrinology
  60. Chapter 29 Enzyme reactors and enzyme electrodes for the liquid chromatographic determination of carbohydrates
    L.J. Nagels · 2002 · Journal of chromatography library
  61. Hyper-variability in Circulating Insulin and Physiological Outcomes in Male High Fat-fed Ins1-/-:Ins2+/- Mice in a Conventional Facility
    Arya E. Mehran, Nicole M. Templeman, Xiaoke Hu, James D. Johnson · 2015 · bioRxiv (Cold Spring Harbor Laboratory)
  62. Influence of Selected Diets on Neural Insulin Activity and Cognitive Function
    Matthew D. Parrott · 2014 · TSpace (University of Toronto)
  63. Trimethylamine N-Oxide (TMAO) links peripheral insulin resistance and cognitive deficiencies in a senescence accelerated mouse model
    Manuel H. Janeiro, Elena Puerta, María Lanz, Fermin Ignacio Milagro, María Javier Ramírez, Maite Solas · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  64. Metabolic Abnormalities in Alzheimer Disease
    Florian M. Gebhardt, Peter Ronald Dodd · 2008 · Springer eBooks
  65. Cholinerge Behandlungsstrategien
    Lutz Frölich, Harald Juergen Hampel, Corinna Gorriz, Uta Schramm · 1999 · Springer eBooks
  66. Basal Forebrain Cholinergic Lesion by 192 IgG-Saporin
    Reinhard Schliebs · 2005 · Humana Press eBooks
  67. Insulin and the Blood‐Brain Barrier
    William A. Banks, Wee Shiong Lim · 2006 · Wiley eBooks
  68. Insulin Receptor and the Pathophysiology of Alzheimer Disease
    Johanna Zemva, M Schubert · 2013 · Wiley eBooks
  69. Modulation of Cognition by Insulin and Aging: Implications for Alzheimer Disease
    Maite Solas, María Javier Ramírez · 2013 · Wiley eBooks
  70. Sinalização intracelular desencadeada por concentrações subtóxicas de estreptozotocina em células neuro-2A: modelo in vitro de neurodegeneração associada à doença de Alzheimer.
    Caio Henrique Mazucanti · 2013
  71. Grundlagen und Klinik von Alzheimer- und anderen neurodegenerativen Demenzen
    Hans Förstl · 2002 · Springer eBooks
  72. Amyloid precursor protein: cellular studies and animal models
    Tatjana Nilsson · 2006 · Figshare
  73. The Effect of Acute LPS-Induced Immune Activation and Brain Insulin Signaling Disruption in a Diabetic Model of Alzheimer's Disease
    Andrew S. Murtishaw · 2020 · Digital Scholarship - UNLV (University of Nevada Reno)
  74. Brain Cholinergic and Dopaminergic Functions in Streptozotocin Induced Diabetic Rats: Effects of Curcumin and Vitamin D3 Supplementation
    T. Peeyush Kumar, C.S. Paulose · 2010 · Dyuthi Digital Repository (Cochin University of Science and Technology)
  75. Neurobiologie der Schizophrenien
    Bernhard Bogerts, Johann Steiner · 2009 · Psychiatrie und Psychotherapie up2date
  76. O aumento do estresse oxidativo no hipocampo e no córtex pré-frontal está relacionado ao comportamento do tipo depressivo em ratos diabéticos por estreptozotocina
    Helen Morais · 2013 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
  77. Neural substrates of insulin-mediated memory facilitation in early Alzheimer's disease; the impact of the apolipoprotein E-epsilon-4 allele on hippocampal insulin responses
    George Thomas · 2009 · KU ScholarWorks (University of Kansas)
  78. Molecular changes during the development of Alzheimer's disease
    Kerstin T.S. Wirz · 2013 · Data Archiving and Networked Services (DANS)
  79. ISULIRESISTACE AD COGITIO : EW APPROACH FOR TREATIG ALZHIEMER'S
    Pranshu Tangri, N. V. Satheesh Madhav · 2011
  80. Review Article Insulin resistance and pathological brain ageing
    Brenna Cholerton, Laura D. Baker, Suzanne Craft · 2011
  81. Genetic and Expressional Studies of Alzheimer's Disease
    Susan Iivonen · 2005
  82. The interplay between vascular and mitochondrial abnormalities in type 2 diabetes and Alzheimer’s disease
    Cristina Carvalho · 2013 · Estudo Geral (Universidade de Coimbra)
  83. Effects of [beta]-amyloid on glucose uptake by cultured hippocampal neurons
    Teerasak Prapong · 1998
  84. Ignoring the Evidence Will Not Stop the Alzheimer's Disease/Diabetes Pandemic
    Suzanne M. de la Monte · 2010 · Journal of Alzheimer s Disease
  85. EFFECTS OF INTRACEREBROVENTRICULAR INJECTION OF DIFFERENT DOSES OF INSULIN ON SPATIAL MEMORY IN HEALTHY MALE WISTAR RATS
    Villayat Ali, Mohades Gisou, Shirin Babri · 2008
  86. THE EFFECT OF METFORMIN ON SPATIAL LEARNING AND MEMORY IN STREPTOZOTOCIN RAT MODEL OF ALZHEIMER'S DISEASE
    Maryam Khosravi, Mohammad Hossein Esmaeili, Mafe Esmaeili Mahin · 2014
  87. Cerebral ageing-the role of insulin and insulin-like growth factor signalling: A review
    Georgia Romain · 2014 · World Journal of Neurology
  88. CELLULAR STUDIES AND ANIMAL MODELS
    Tatjana Nilsson · 2006
  89. Effects of insulin gene dosage on body weight and glucose homeostasis
    Arya E. Mehran · 2015 · cIRcle (University of British Columbia)
  90. Dementia and Insulin Resistance
    Domenico Bosco, Massimiliano Plastino, Domenico Pirritano, Dario Cristiano, Carmen Colica, Caterina Ermio, Matteo De Bartolo, Antonietta Fava · 2014 · Elsevier eBooks
  91. Unravelling the genetic components of late onset Alzheimer's disease.
    Gillian Hamilton · 2005 · OpenGrey (Institut de l'Information Scientifique et Technique)
  92. Global action against dementia call for innovations
    Dajue Wang · 2016 · Translational Neuroscience and Clinics
  93. Caracterização das alterações na via hipocampo-córtex pré-frontal medial em modelo farmacológico da doença de Alzheimer
    Ingrid de Miranda Esteves · 2016 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  94. The Genetic and Behavioral Analysis of Insulin Signaling in Caenorhabditis Elegans Learning and Memory
    Chia Hsun Anthony Lin · 2010 · TSpace (University of Toronto)
  95. Genes, Aging, and Parkinson’s Disease
    Chiara Milanese, Pier G. Mastroberardino · 2017 · Royal Society of Chemistry eBooks
  96. Type II Diabetes and Metabolic Syndrome as Risk Factors for Alzheimer’s Disease
    A. A. Farooqui · 2017 · Elsevier eBooks
  97. Avaliação de efeitos neuroprotetores e comportamentais do tratamento com geleia real em ratos Wistar submetidos à administração intracerebroventicular de estreptozotocina, um modelo da doença de Alzheimer esporádica
    Tiago Guardia de Souza e Silva · 2017 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  98. Insulin and Brain Injury: Memory, Metabolism and Microglia
    Fiona Brabazon · 2016
  99. The Role of Insulin Resistance and Signaling in Dementia
    Aaron M. Koenig, Zoe Arvanitakis, Steven Edward Arnold · 2018 · Elsevier eBooks
  100. Interactions Between Age, Diet, and Insulin and Their Effect on Cognition
    Elisa Félix‐Soriano, María Jesús Moreno-Aliaga, María Javier Ramírez, Maite Solas · 2018 · Elsevier eBooks