Cited by 255Amino Acid Enzymes and MetabolismCancer, Hypoxia, and MetabolismPolyamine Metabolism and Applications

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The metabolism of proline, a stress substrate, modulates carcinogenic pathways

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Phang, James M., Donald, Steven P., Pandhare, Jui, Liu, Yongmin·2008·Amino Acids

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Abstract

The resurgence of interest in tumor metabolism has led investigators to emphasize the metabolism of proline as a "stress substrate" and to suggest this pathway as a potential anti-tumor target. Proline oxidase, a.k.a. proline dehydrogenase (POX/PRODH), catalyzes the first step in proline degradation and uses proline to generate ATP for survival or reactive oxygen species for programmed cell death. POX/PRODH is induced by p53 under genotoxic stress and initiates apoptosis by both mitochondrial and death receptor pathways. Furthermore, POX/PRODH is induced by PPARgamma and its pharmacologic ligands, the thiazolidinediones. The anti-tumor effects of PPARgamma may be critically dependent on POX/PRODH. In addition, it is upregulated by nutrient stress through the mTOR pathway to maintain ATP levels. We propose that proline is made available as a stress substrate by the degradation of collagen in the microenvironmental extracellular matrix by matrix metalloproteinases. In a manner analogous to autophagy, this proline-dependent process for bioenergetics from collagen in extracellular matrix can be designated "ecophagy".

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Matrix metalloproteinases and the regulation of tissue remodelling
Page-McCaw, A., Ewald, A. J., & Werb, Z. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2125 · Cited by 2,630
A model for p53-induced apoptosis
Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/38525 · Cited by 2,500
Matrix metalloproteinases as modulators of inflammation and innate immunity
Parks, W. C., Wilson, C. L., & López-Boado, Y. S. (2004) · Nature Reviews Immunology · doi:10.1038/nri1418 · Cited by 1,929
Autophagy: molecular machinery for self-eating
Yorimitsu, T., & Klionsky, D. J. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401765 · Cited by 1,566
Oncogenic alterations of metabolism
Dang, C. V., & Semenza, G. L. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01344-9 · Cited by 1,106
Hypoxia-Inducible Factor 1 (HIF-1) Pathway
Semenza, G. L. (2007) · Science s STKE · doi:10.1126/stke.4072007cm8 · Cited by 942
Fuel feeds function: energy metabolism and the T-cell response
Fox, C. J., Hammerman, P. S., & Thompson, C. B. (2005) · Nature reviews. Immunology · doi:10.1038/nri1710 · Cited by 841
Matrix metalloproteinases (MMPs) in health and disease: an overview
Malemud, C. (2006) · Frontiers in Bioscience · doi:10.2741/1915 · Cited by 705
Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms
Straus, D. S., & Glass, C. K. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.09.003 · Cited by 563
Do all programmed cell deaths occur via apoptosis?
Schwartz, L. M., Smith, S. W., Jones, M. E. E., & Osborne, B. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.3.980 · Cited by 533

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Hechtman P (2001) Prolidase deficiency. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) Metabolic and molecular basis of inherited disease. McGraw-Hill, New York, pp 1839–1856
Hu C-AA, Yu J, Lin W-W, Donald SP, Sun X-Y, Almashanu S, Steel G, Phang JM, Vogelstein B, Valle D (2001) Overexpression of proline oxidase, a p53 induced gene (PIG6) induces reactive oxygen species generation and apoptosis in cancer cells. Proc Am Assoc Cancer Res 42:225
Phang JM, Hu CA, Valle D (2001) Disorders of proline and hydroxyproline metabolism. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) Metabolic and molecular basis of inherited disease. McGraw-Hill, New York, pp 1821–1838
Warburg O (1930) Ueber den Stoffwechsel der Tumoren. Constable, London

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Troglitazone induced apoptosis via PPARγ activated POX-induced ROS formation in HT29 cells.
Wang, J., Lv, X., Shi, J., Hu, X., & Du, Y. (2011) · PubMed · doi:10.3967/0895-3988.2011.04.010 · Cited by 16
Metabolomics of Gastric Cancer
Kadam, W. S., Wei, B., & Li, F. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-51652-9_20 · Cited by 15
Acetylenic derivative of betulin induces apoptosis in endometrial adenocarcinoma cell line
Szoka, Ł., Karna, E., Hlebowicz‐Sarat, K., Karaszewski, J., Boryczka, S., & Palka, J. A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.08.104 · Cited by 15
NSAIDs Induce Proline Dehydrogenase/Proline Oxidase-Dependent and Independent Apoptosis in MCF7 Breast Cancer Cells
Kazberuk, A., Chalecka, M., Palka, J. A., Bielawska, K., & Surażyński, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073813 · Cited by 14
Multifunctionality and Possible Medical Application of the BPC 157 Peptide—Literature and Patent Review
Józwiak, M., Bauer, M., Kamysz, W., & Kleczkowska, P. (2025) · Pharmaceuticals · doi:10.3390/ph18020185 · Cited by 14
A validated ultra-performance liquid chromatography with diode array detection coupled to electrospray ionization and triple quadrupole mass spectrometry method to simultaneously quantify taurine, homotaurine, hypotaurine and amino acids in macro- and microalgae
Terriente-Palacios, C., Diaz, I., & Castellari, M. (2018) · Journal of Chromatography A · doi:10.1016/j.chroma.2018.12.058 · Cited by 14
Proline oxidase silencing induces proline-dependent pro-survival pathways in MCF-7 cells
Zaręba, I., Celińska-Janowicz, K., Surażyński, A., Miltyk, W., & Palka, J. A. (2018) · Oncotarget · doi:10.18632/oncotarget.24466 · Cited by 14
Identifying Metabolic Perturbations and Toxic Effects of Rac-Metalaxyl and Metalaxyl-M in Mice Using Integrative NMR and UPLC-MS/MS Based Metabolomics
Zhang, P., Wang, S., He, Y., Xu, Y., Shi, D., Yang, F., Yu, W., Zhu, W., & He, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215457 · Cited by 14
Various proline food sources and blood pressure: substitution analysis
Teymoori, F., Asghari, G., Farhadnejad, H., Nazarzadeh, M., Atifeh, M., Mirmiran, P., & Azizi, F. (2019) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2019.1650004 · Cited by 13
Distinct serum metabolomic signatures of multiparous and primiparous dairy cows switched from a moderate to high-grain diet during early lactation
Pacífico, C., Stauder, A., Reisinger, N., Schwartz, H., & Zebeli, Q. (2020) · Metabolomics · doi:10.1007/s11306-020-01712-z · Cited by 13
Redox Dysregulation and Oxidative Stress in Schizophrenia: Nutrigenetics as a Challenge in Psychiatric Disease Prevention
Kim, Q., Conus, P., & Cuénod, M. (2010) · Lifestyle Genomics · doi:10.1159/000324366 · Cited by 13
Dietary hydroxyproline supplementation improves the muscle texture and extends the shelf life of abalone Haliotis discus hannai
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Effects of dietary L-arginine levels on small intestine protein turnover and the expression of genes related to protein synthesis and proteolysis of layers
Miao, L. P., Yuan, C., Dong, X., Zhang, X. Y., Zhou, M., & Zou, X. T. (2017) · Poultry Science · doi:10.3382/ps/pew471 · Cited by 12
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Determination of proline in human plasma samples using the encapsulation of proline dehydrogenase enzyme in dendritic silica: a new platform for the enzymatic biosensing of amino acids
Mirzaie, A., Saadati, A., Hassanpour, S., Hasanzadeh, M., Siahi‐Shadbad, M., & Jouyban, A. (2019) · Analytical Methods · doi:10.1039/c9ay01732a · Cited by 11
Capturing Transitional Pluripotency through Proline Metabolism
Minchiotti, G., D’Aniello, C., Fico, A., Cesare, D. D., & Patriarca, E. J. (2022) · Cells · doi:10.3390/cells11142125 · Cited by 10
Metformin Induces PRODH/POX-Dependent Apoptosis in Breast Cancer Cells
Huynh, T. Y. L., Ościłowska, I., Szoka, Ł., Piktel, E., Baszanowska, W., Bielawska, K., Bucki, R., Miltyk, W., & Palka, J. A. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.869413 · Cited by 10
Effects of deranged metabolism on epigenetic changes in cancer
Chandra, V., & Hong, K. (2015) · Archives of Pharmacal Research · doi:10.1007/s12272-015-0561-3 · Cited by 11
Revealing novel insights on how oral supplementation with collagen peptides may prevent hair loss: Lessons from the human hair follicle organ culture
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l-Proline Alters Energy Metabolism in Brain Cortical Tissue Slices
Das, A., Gauthier-Coles, G., Bröer, S., & Rae, C. D. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04262-1 · Cited by 9
Nanoconfined liquid phase nanoextraction combined with in-fiber derivatization for simultaneous quantification of seventy amino-containing metabolites in plasma by LC-MS/MS: Exploration of lung cancer screening model
Yu, C., Zhang, Q., Wang, L., Zhang, Y., Cui, M., Kai-shun, B., Li, D., & Li, Q. (2022) · Talanta · doi:10.1016/j.talanta.2022.123452 · Cited by 9
Combined Oral Arginine and Monosodium Glutamate Exposure Induces Adverse Response on the Prostate Function and Testis Histology of Rats
Egbuonu, A. C. C. (2013) · Journal of Pharmaceutical Research International · doi:10.9734/bjpr/2013/2172 · Cited by 9
Next-generation sequencing of prolidase gene identifies novel and common variants associated with low prolidase in coronary artery ectasia
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Du, L., Li, S., Xiao, X., Li, J., Sun, Y., Ji, S., Jin, H., Hua, Z., Ma, J., Wang, X., et al. (2023) · MedComm – Oncology · doi:10.1002/mog2.32 · Cited by 8
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Hong, Y., Lv, Z., Xing, Z., Xu, H., Chand, H., Wang, J., & Li, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1325447 · Cited by 8
Effects of proline on growth performance, protein synthesis and cold resistance in white shrimp (Litopenaeus vannamei)
Zou, D., Yang, M. J., Chen, Z., Lin, P., Li, Y., Liu, X., Tan, B., & Ye, C. (2025) · Animal nutrition · doi:10.1016/j.aninu.2025.06.002 · Cited by 8
Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries
Tong, T. Y. N., Clarke, R., Schmidt, J. A., Huybrechts, I., Noor, U., Forouhi, N. G., Imamura, F., Travis, R. C., Weiderpass, E., Aleksandrova, K., et al. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03251-4 · Cited by 8
Marine Cyclic Dipeptide Cyclo (L-Leu-L-Pro) Protects Normal Breast Epithelial Cells from tBHP-induced Oxidative Damage by Targeting CD151
Deepak, K. G. K., Kumari, S., & Malla, R. R. (2021) · Archives of Breast Cancer · doi:10.32768/abc.202183162-173 · Cited by 8
Circulatory amino acid responses to milk consumption in dairy and lactose intolerant individuals
Prodhan, U. K., Milan, A. M., Shrestha, A., Vickers, M. H., Cameron‐Smith, D., & Barnett, M. P. G. (2022) · European Journal of Clinical Nutrition · doi:10.1038/s41430-022-01119-0 · Cited by 7
Discovery of the Membrane Binding Domain in Trifunctional Proline Utilization A
Christgen, S. L., Zhu, W., Sanyal, N., Bibi, B., Tanner, J. J., & Becker, D. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b01008 · Cited by 7
Activation of proline metabolism maintains ATP levels during cocaine-induced polyADP-ribosylation
Dash, S., Dash, C., & Pandhare, J. (2021) · Amino Acids · doi:10.1007/s00726-021-03065-w · Cited by 5
Effect of potassium chloride-induced stress on germination potential of Artemisia annua L. varieties
Prasad, P., Mehdi, J., Mohan, R. S., Goyal, N., Luqman, S., Khare, P., & Kumar, B. (2018) · Journal of Applied Research on Medicinal and Aromatic Plants · doi:10.1016/j.jarmap.2018.03.005 · Cited by 6
UPLC‑MS/MS‑based metabolomic characterization and comparison of pancreatic adenocarcinoma tissues using formalin‑fixed, paraffin‑embedded and optimal cutting temperature‑embedded materials
Feng, D., Yuan, J., Liu, Q., Liu, L., Zhang, X., Wu, Y., Qian, Y., Chen, L., Shi, Y. X., & Gu, M. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4898 · Cited by 6
Metabolomics Signatures of Atherosclerosis in Cardiovascular Disease: A Narrative Systematic Review
Pibiri, M., Noto, A., Dalu, A., Muntoni, S., Kopeć, K. K., Spada, M., Atzori, L., & Piras, C. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14228028 · Cited by 5

Authors: Phang, J. M., Donald, S. P., Pandhare, J., & Liu, Y.
Affiliations: Frederick National Laboratory for Cancer Research (US)
National Cancer Institute (US)
Science Applications International Corporation (United States) (US)
Corresponding author: Phang, James M.
ORCID: Phang, James M.
Pandhare, Jui
Liu, Yongmin
Venue: Amino Acids
Publisher: Springer Science and Business Media LLC
Published: 2008-04-10
Volume: 35
Issue: 4
Pages: 681-690
ISSN: 0939-4451 (ISSN-L)
1438-2199
DOI: 10.1007/s00726-008-0063-4
OpenAlex: W1986586503
Cited by: 252
References: 60
Citations by year: 2026: 3 · 2025: 14 · 2024: 8 · 2023: 13 · 2022: 15 · 2021: 20 · 2020: 12 · 2019: 15 · 2018: 15 · 2017: 18 · 2016: 10 · 2015: 15 · 2014: 15 · 2013: 13 · 2012: 11
FWCI: 1.35
Type: journal article
Language: en
Open access: green
zenodo.org
Licence: public-domain
www.springer.com/tdm (tdm)
Locations: Amino Acids (publishedVersion)
PubMed (publishedVersion)
Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, public-domain)
Funders: National Institutes of Health (n01co12400-79-0-22)
National Cancer Institute (N01CO12400)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
Keywords: proline metabolism, proline oxidase, proline dehydrogenase, cancer metabolism, p53, apoptosis, PPARγ, thiazolidinediones, mTOR, nutritional stress, collagen degradation, matrix metalloproteinases, extracellular matrix, reactive oxygen species, carcinogenesis
MeSH terms: Adenosine Triphosphate, Autophagy, Catalysis, Ligands, Models, Biological, Neoplasms, Proline, Proline Oxidase, Protein Kinases, Gene Expression Regulation, Enzymologic, Tumor Suppressor Protein p53, Apoptosis, Thiazolidinediones, PPAR delta, TOR Serine-Threonine Kinases

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The metabolism of proline, a stress substrate, modulates carcinogenic pathways

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