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Matrix metalloproteinases and the regulation of tissue remodelling

Page-McCaw, Andrea, Ewald, Andrew J., Werb, Zena·2007·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm2125
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Abstract

Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian metamorphosis, yet they have attracted more attention because of their roles in disease. Despite intensive scrutiny in vitro, in cell culture and in animal models, the normal physiological roles of these extracellular proteases have been elusive. Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.

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Metadata

Authors
Page-McCaw, A., Ewald, A. J., & Werb, Z.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2007-03
Volume
8
Issue
3
Pages
221-233
ISSN
  • 1471-0072
  • 1471-0080
DOI
10.1038/nrm2125
Cited by
2,630
References
4
Language
en
Licence
www.springer.com/tdm (tdm)

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