Cited by 113Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchTryptophan and brain disorders

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Serotonin and molecular neuroimaging in humans using PET

Saulin, Anne, Savli, Markus, Lanzenberger, Rupert·2012·Amino Acids

DOI 10.1007/s00726-011-1078-9

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Abstract

The serotonergic system is one of the most important modulatory neurotransmitter systems in the human brain. It plays a central role in major physiological processes and is implicated in a number of psychiatric disorders. Along with the dopaminergic system, it is also one of the phylogenetically oldest human neurotransmitter systems and one of the most diverse, with 14 different receptors identified up to this day, many of whose function remains to be understood. The system's functioning is even more diverse than the number of its receptors, since each is implicated in a number of different processes. This review aims at illustrating the distribution and summarizing the main functions of the serotonin (5-hydroxytryptamin, 5-HT) receptors as well as the serotonin transporter (SERT, 5-HTT), the vesicular monoamine transporter 2, monoamine oxidase type A and 5-HT synthesis in the human brain. Recent advances in in vivo quantification of these different receptors and enzymes that are part of the serotonergic system using positron emission tomography are described.

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Authors: Saulin, A., Savli, M., & Lanzenberger, R.
Affiliations: Medical University of Vienna (AT)
Corresponding author: Lanzenberger, Rupert
ORCID: Saulin, Anne
Lanzenberger, Rupert
Venue: Amino Acids
Publisher: Springer Science and Business Media LLC
Published: 2011-09-24
Volume: 42
Issue: 6
Pages: 2039-2057
ISSN: 0939-4451 (ISSN-L)
1438-2199
DOI: 10.1007/s00726-011-1078-9
OpenAlex: W2054129965
Cited by: 113
References: 207
Citations by year: 2026: 5 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 5 · 2020: 7 · 2019: 2 · 2018: 11 · 2017: 10 · 2016: 8 · 2015: 7 · 2014: 9 · 2013: 7 · 2012: 8
FWCI: 0.73
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Amino Acids (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: serotonin, serotonergic system, serotonin receptors, serotonin transporter, vesicular monoamine transporter 2, monoamine oxidase A, serotonin synthesis, positron emission tomography, human brain, mental illness
MeSH terms: Animals, Brain, Humans, Monoamine Oxidase, Synaptic Transmission, Receptors, Serotonin, Serotonin, Serotonin Agents, Radiopharmaceuticals, Positron-Emission Tomography, Serotonin Plasma Membrane Transport Proteins, Vesicular Monoamine Transport Proteins, Mice, Molecular Imaging

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Serotonin and molecular neuroimaging in humans using PET

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