The DOI matches its Crossref record; 207 of the 207 references it cites were found in a registry or an index.
Serotonin and molecular neuroimaging in humans using PET
Abstract
The serotonergic system is one of the most important modulatory neurotransmitter systems in the human brain. It plays a central role in major physiological processes and is implicated in a number of psychiatric disorders. Along with the dopaminergic system, it is also one of the phylogenetically oldest human neurotransmitter systems and one of the most diverse, with 14 different receptors identified up to this day, many of whose function remains to be understood. The system's functioning is even more diverse than the number of its receptors, since each is implicated in a number of different processes. This review aims at illustrating the distribution and summarizing the main functions of the serotonin (5-hydroxytryptamin, 5-HT) receptors as well as the serotonin transporter (SERT, 5-HTT), the vesicular monoamine transporter 2, monoamine oxidase type A and 5-HT synthesis in the human brain. Recent advances in in vivo quantification of these different receptors and enzymes that are part of the serotonergic system using positron emission tomography are described.
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“The high presence of the 5-HT2A receptor in regions like the prefrontal cortex—integral for higher-order cognitive functions—underscores the transformative nature of these compounds on cognition and perception [62, 63].”
From Mindfulness meditation and psychedelics: potential synergies and commonalities (2023) · cites this paper as [63]
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Metadata
- Authors
- Saulin, A., Savli, M., & Lanzenberger, R.
- Affiliations
- Medical University of Vienna (AT)
- Corresponding author
- Lanzenberger, Rupert
- Venue
- Amino Acids
- Published
- 2011-09-24
- Volume
- 42
- Issue
- 6
- Pages
- 2039-2057
- ISSN
- 0939-4451 (ISSN-L)
- 1438-2199
- OpenAlex
- W2054129965
- Cited by
- 113
- References
- 207
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 5 · 2020: 7 · 2019: 2 · 2018: 11 · 2017: 10 · 2016: 8 · 2015: 7 · 2014: 9 · 2013: 7 · 2012: 8
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Amino Acids (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- serotonin, serotonergic system, serotonin receptors, serotonin transporter, vesicular monoamine transporter 2, monoamine oxidase A, serotonin synthesis, positron emission tomography, human brain, mental illness
- MeSH terms
- Animals, Brain, Humans, Monoamine Oxidase, Synaptic Transmission, Receptors, Serotonin, Serotonin, Serotonin Agents, Radiopharmaceuticals, Positron-Emission Tomography, Serotonin Plasma Membrane Transport Proteins, Vesicular Monoamine Transport Proteins, Mice, Molecular Imaging
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