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Cited by 7Knee injuries and reconstruction techniquesTendon Structure and TreatmentPeriodontal Regeneration and Treatments

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The fate and role of bone graft-derived cells after autologous tendon and bone transplantation into the bone tunnel

Komiyama, Hiroto, Arai, Yuji, Kajikawa, Yoshihiko, Yoshida, Atsuhiko, Morihara, Toru, Terauchi, Ryu, Kida, Yoshikazu, Fujiwara, Hiroyoshi, Kubo, Toshikazu, Kawata, Mitsuhiro·2013·Journal of Orthopaedic Science
DOI 10.1007/s00776-012-0335-4
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Abstract

Background Grafting bone between the tendon graft and the bone tunnel in anterior cruciate ligament reconstruction increases the mechanical strength of the tendon graft. However, the biological role of the bone graft is unclear. The purpose of this research was to elucidate the role of bone graft cells after autologous tendon graft into the bone tunnel with an autologous bone graft in green fluorescent protein (GFP) transgenic rats. Methods The Achilles tendons of Sprague-Dawley (SD) wild-type rats and bone of GFP rats were harvested and transplanted into bone tunnels drilled in the femurs at the knees of SD rats. The femurs were harvested at 1, 2, and 4 weeks after transplantation and histologically investigated using hematoxylin and eosin staining and immunostaining of heat shock protein 47 (HSP47), macrophages, and type I and type III collagens. Biomechanical tests were performed on the tendon graft 2 and 4 weeks after transplantation to evaluate the ultimate force to failure. Results A small number of GFP-positive cells was seen in the tendon graft 2 weeks after transplantation. The cell count in the tendon graft was increased at 4 weeks after transplantation. HSP47-positive cells and macrophage-stained cells present in the tendon graft corresponded with the GFP-positive cells. By 2 weeks after transplantation, the relative areas of immunostained type I and III collagens in the tendon graft had declined significantly in the bone graft group compared to the control. The ultimate failure load in the bone graft group was higher than that in the control group at both 2 and 4 weeks after transplantation. Conclusions This research showed that, within 4 weeks of transplantation, bone graft cells migrate to the tendon graft, where they differentiate into cells involved in collagen production and macrophages. Bone graft cells may contribute to the early stage remodeling of tendon grafts.

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Metadata

Authors
Komiyama, H., Arai, Y., Kajikawa, Y., Yoshida, A., Morihara, T., Terauchi, R., Kida, Y., Fujiwara, H., Kubo, T., & Kawata, M.
Affiliations
Kyoto Prefectural University of Medicine (JP)
Corresponding author
Arai, Yuji
ORCID
Venue
Journal of Orthopaedic Science
Publisher
Elsevier BV
Published
2013-11
Volume
18
Issue
6
Pages
994-1004
ISSN
0949-2658 (ISSN-L)
DOI
10.1007/s00776-012-0335-4
OpenAlex
W2089393366
Cited by
7
References
1
Citations by year
2021: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1
FWCI
0.65
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Orthopaedic Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (24300128)
Topics
  • Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
Keywords
autologous bone graft, autologous tendon graft, anterior cruciate ligament reconstruction, bone tunnel, HSP47, macrophages, type I collagen, type III collagen, ultimate failure load, Achilles tendon
MeSH terms
Achilles Tendon, Animals, Biomechanical Phenomena, Cell Movement, Cell Survival, Disease Models, Animal, Female, Femur, Graft Rejection, Graft Survival, Immunohistochemistry, Knee Joint, Osteocytes, Random Allocation, Risk Factors, Tensile Strength, Transplantation, Autologous, Wound Healing, Bone Transplantation, Tissue Transplantation, Rats, Sprague-Dawley, Microscopy, Confocal, Tissue and Organ Harvesting, Animals, Genetically Modified, Rats

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