Analysis of a Semitendinosus Autograft in a Rabbit Model

Blickenstaff, Kyle R.; Grana, William A.; Egle, Davis

doi:10.1177/036354659702500420

Cited by 164Knee injuries and reconstruction techniquesTendon Structure and TreatmentFoot and Ankle Surgery

Analysis of a Semitendinosus Autograft in a Rabbit Model

Blickenstaff, Kyle R., Grana, William A., Egle, Davis·1997·The American Journal of Sports Medicine

DOI 10.1177/036354659702500420

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Abstract

The purpose of this study was to evaluate the histo logic and biomechanical changes that occur between 12 and 52 weeks in an intraarticular, semitendinosus autograft placed through tibial and femoral drill holes in a rabbit model. The results of this study show that, in this rabbit model, the soft tissue graft maintained its biologic fixation in the osseous tunnel when stressed to failure at 1 year. The bony fixation occurred by the formation of an indirect tendon insertion, and this for mation was complete by 26 weeks. At 52 weeks, large differences persisted in the strength and stiffness of the graft compared with the normal semitendinosus tendon and anterior cruciate ligament. Based on the results of this study, we support a cautious approach in returning patients to early full activity, including sports, after anterior cruciate ligament reconstruction with a semitendinosus autograft.

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This is consistent with previous animal studies that reported excessive graft necrosis in the early phase, followed by an influx of fibroblasts.
“This is consistent with previous animal studies that reported excessive graft necrosis in the early phase, followed by an influx of fibroblasts [53, 67, 68].”
From A new biological enhancement therapy for anterior cruciate ligament reconstruction: the preclinical proof of anterior cruciate ligament reconstruction with tendon graft reseeded with autologous anterior cruciate ligament-derived cells (2025) · cites this paper as [68]

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Goodhart, C., & Md, P. (2016)
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Self-citation
Biomechanical and Histological Evaluations of the Doubled Semitendinosus Tendon Autograft After Anterior Cruciate Ligament Reconstruction in Sheep
Kondo, E., Yasuda, K., Katsura, T., Hayashi, R., Kotani, Y., & Tohyama, H. (2011) · The American Journal of Sports Medicine · doi:10.1177/0363546511426417 · Cited by 68 · see citing works
Untitled work
(2000) · PubMed · Cited by 154 · see citing works
Self-citation

Authors: Blickenstaff, K. R., Grana, W. A., & Egle, D.
Affiliations: Winchester Medical Center (US)
University of Oklahoma Health Sciences Center (US)
University of Oklahoma (US)
Venue: The American Journal of Sports Medicine
Publisher: SAGE Publications
Published: 1997-07
Volume: 25
Issue: 4
Pages: 554-559
ISSN: 0363-5465 (ISSN-L)
1552-3365
DOI: 10.1177/036354659702500420
OpenAlex: W2083179020
Cited by: 164
References: 15
Citations by year: 2026: 1 · 2025: 2 · 2023: 2 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 5 · 2013: 8 · 2012: 5
FWCI: 4.22
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: The American Journal of Sports Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
Health Sciences › Medicine › Orthopedics and Sports Medicine › Foot and Ankle Surgery
Keywords: semitendinosus autograft, anterior cruciate ligament reconstruction, rabbit model, graft histology, graft biomechanics, graft stiffness, return to sport
MeSH terms: Activities of Daily Living, Animals, Biomechanical Phenomena, Collagen, Connective Tissue, Disease Models, Animal, Elasticity, Evaluation Studies as Topic, Femur, Follow-Up Studies, Hindlimb, Humans, Rabbits, Rupture, Sports, Stress, Mechanical, Tendons, Tibia, Transplantation, Autologous, Wound Healing, Anterior Cruciate Ligament

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Analysis of a Semitendinosus Autograft in a Rabbit Model

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