Pulmonary hypertension in primary Sjögren's syndrome: report of a case and review of the literature
Abstract
A 61-year-old female with a history of vaginal dryness, Raynaud's phenomenon, xerostomia and xerophthalmia presented with exertional dyspnoea and weakness. Laboratory and instrumental examinations enabled us to make the diagnosis of primary Sjögren's syndrome, while cardiologic and imaging investigations evidenced isolated pulmonary hypertension and ruled out pulmonary fibrosis. Oral anticoagulant and furosemide therapy induced a partial improvement of exertional dyspnoea and weakness.
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Several diseases that share both disproportionately high rates of vascular disease and PH, including Sjögren's and systemic sclerosis, HIV, and cystic fibrosis, also feature dysregulated salivary flow and altered oral microbial populations.
“Significantly, several diseases that share both disproportionately high rates of vascular disease and PH, including Sjögren's and systemic sclerosis[294–297], HIV[7,11], and cystic fibrosis[298] also feature dysregulated salivary flow[299–302] and altered oral microbial populations[224,303–306].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [295]
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- Authors
- Bertoni, M., Niccoli, L., Porciello, G., Storri, L., Nannini, C., Manes, A., Palazzini, M., Galiè, N., & Cantini, F.
- Affiliations
- Ospedale di Prato Santo Stefano (IT)
- University of Bologna (IT)
- Corresponding author
- Bertoni, M.
- Venue
- Clinical Rheumatology
- Published
- 2005-05-19
- Volume
- 24
- Issue
- 4
- Pages
- 431-434
- ISSN
- 0770-3198 (ISSN-L)
- 1434-9949
- OpenAlex
- W2086005003
- Cited by
- 21
- References
- 26
- Citations by year
- 2025: 1 · 2021: 1 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 1 · 2013: 1
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Clinical Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Keywords
- pulmonary hypertension, primary Sjögren's syndrome, exertional dyspnea, Raynaud's phenomenon, xerostomia, xerophthalmia, anticoagulation, furosemide
- MeSH terms
- Anticoagulants, Drug Therapy, Combination, Electrocardiography, Female, Follow-Up Studies, Furosemide, Humans, Hypertension, Pulmonary, Middle Aged, Respiratory Function Tests, Severity of Illness Index, Sjogren's Syndrome, Tomography, X-Ray Computed, Treatment Outcome, Risk Assessment, Ultrasonography, Doppler
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