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Expression analysis of beta-secretase 1 (BACE1) and its naturally occurring antisense (BACE1-AS) in blood of epileptic patients

Mazdeh, Mehrdokht, Komaki, Alireza, Omrani, Mir Davood, Gharzi, Vajihe, Sayad, Arezou, Taheri, Mohammad, Ghafouri-Fard, Soudeh·2018·Neurological Sciences
DOI 10.1007/s10072-018-3458-3
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Abstract

Beta-secretase 1 (BACE1) gene encodes a transmembrane protease from the peptidase A1 family of aspartic proteases whose role in the pathogenesis of Alzheimer's disease has been assessed. The enzymatic activity of BACE1 on several proteins implicated in epileptogenesis implies its role in the pathogenesis of epilepsy. In the present study, we assessed expression of BACE1 and its naturally occurring antisense (BACE1-AS) in peripheral blood of 40 epileptic patients and 40 age- and sex-matched healthy subjects. We did not detect either any difference in the expression of these genes between cases and controls or significant correlation between their expressions and participants' age. However, we demonstrated a significant correlation between expression levels of BACE1 and BACE1-AS which supports the previously suggested feed-forward mechanism of regulation between these two transcripts. Future studies in larger sample sizes are needed to elaborate the function of BACE1 in epilepsy.

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Crossref · 10.1007/s10072-018-3458-3

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  • Dysregulation of the BACE1/BACE1-AS axis has been implicated in both cardiac dysfunction and epilepsy.

    “Dysregulation of the BACE1/BACE1‐AS axis also has been implicated in both cardiac dysfunction and epilepsy.”

    From BACE1: More than just a β‐secretase (2022) · cites this paper as [65]

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Research works printed but not linked: 22

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Metadata

Authors
Mazdeh, M., Komaki, A., Omrani, M. D., Gharzi, V., Sayad, A., Taheri, M., & Ghafouri-Fard, S.
ORCID
Taheri, Mohammad
Venue
Neurological Sciences
Publisher
Springer Science and Business Media LLC
Published
2018-06-02
Volume
39
Issue
9
Pages
1565-1569
ISSN
  • 1590-1874
  • 1590-3478
DOI
10.1007/s10072-018-3458-3
Cited by
15
References
1
Language
en
Licence
www.springer.com/tdm (tdm)

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