Decreased platelet glutamate uptake and genetic risk factors in patients with Parkinson's disease
Abstract
Genetic risk factors seem to play a role in sporadic Parkinson's disease (PD), maybe triggering oxidative stress and excitotoxicity within substantia nigra. However, genetic factors act at systemic level: reduced activity of mitochondrial enzymes and decreased glutamate uptake have been shown in platelets from PD patients. In this study we investigated glutamate uptake in platelets from 38 sporadic PD patients, 13 patients with parkinsonian syndromes and 28 controls and assessed polymorphisms of alpha-synuclein and ApoE genes. A 48% reduction of glutamate uptake p)<0.0001) was observed in PD patients which, with respect to control groups, correlated with the disease severity (r = -0.44, p < 0.05). Genetic studies of this population did not show differences between PD and controls, nor correlations with platelet glutamate uptake.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Glutamate in the brain is mainly cleared by GLT-1.
“Glutamate in the brain is mainly cleared by GLT-1”
From Neuroprotective Effect of Ceftriaxone on MPTP‐Induced Parkinson’s Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota (2021) · cites this paper as [26]
GLT-1 shows dysfunction or decreased expression in patients with neurodegenerative diseases such as PD, AD, or ALS.
“GLT-1 shows dysfunction or decreased expression in patients with neurodegenerative diseases such as PD [26], AD [27], or ALS [17]”
From Neuroprotective Effect of Ceftriaxone on MPTP‐Induced Parkinson’s Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota (2021) · cites this paper as [26]
Cites
Recent developments in Parkinson's disease
Fahn, S., Elton, R., MARSDEN, C. D., Calne, D. B., & Goldstein, M. (1986) · Raven Press eBooks · Cited by 2,306 · see citing works
Mitochondrial Complex I Deficiency in Parkinson's Disease
Schapira, A. H. V., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., & Marsden, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb02325.x · Cited by 2,283 · see citing works
Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes
Volterra, A., Trotti, D., Tromba, C., FLORIDI, S., & Racagni, G. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-02924.1994 · Cited by 457 · see citing works
Shimura, H., Hattori, N., Kubo, S., Yoshikawa, M., Kitada, T., Matsumine, H., Asakawa, S., Minoshima, S., Yamamura, Y., Shimizu, N., et al. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199905)45:5 · Cited by 282 · see citing works
Benecke, R., Strumper, P., & Weiss, H. (1993) · Brain · doi:10.1093/brain/116.6.1451 · Cited by 220 · cited 1× · see citing works
“Impaired mitochondrial function in PD are also described in peripheral tissues and in platelets [3], where we have previously reported decreased glutamate uptake, corre-”
BackgroundVariability and validity of polymorphism association studies in Parkinson’s disease
Tan, E., Khajavi, M., Thornby, J. I., Nagamitsu, S., Jankovic, J. J., & Ashizawa, T. (2000) · Neurology · doi:10.1212/wnl.55.4.533 · Cited by 217 · see citing works
The Human Platelet as a Model for the Glutamatergic Neuron: Platelet Uptake of L‐Glutamate
Mangano, R. M., & Schwarcz, R. M. (1981) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1981.tb01701.x · Cited by 80 · see citing works
Reduced platelet glutamate uptake in Parkinson's disease
Ferrarese, C., Zoia, C., Pecora, N., Piolti, R., Frigo, M., Bianchi, G., Sala, G., Begni, B., Riva, R., & Frattola, L. (1999) · Journal of Neural Transmission · doi:10.1007/s007020050189 · Cited by 51 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Zhou, X., Lu, J., Wei, K., Wei, J., Tian, P., Yue, M., Wang, Y., Hong, D., Li, F., Wang, B., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9424582 · Cited by 85 · see citing works
Ceftriaxone Protects Astrocytes from MPP+ via Suppression of NF-ΚB/JNK/c-Jun Signaling
Zhang, Y., Zhang, X., & Qu, S. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-8845-z · Cited by 39 · see citing works
- Authors
- Ferrarese, C., Tremolizzo, L., Rigoldi, M., Sala, G., Brighina, L., Ricci, G., Albizzati, M. G., Piolti, R., Crosti, F., Dalpr�, L., Frattola, L., & Begni, B.
- Affiliations
- University of Milano-Bicocca (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Venue
- Neurological Sciences
- Published
- 2001-02-01
- Volume
- 22
- Issue
- 1
- Pages
- 65-66
- ISSN
- 1590-1874 (ISSN-L)
- 1590-3478
- OpenAlex
- W1988015462
- Cited by
- 39
- References
- 8
- Citations by year
- 2025: 2 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 1 · 2014: 1
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- Parkinson's disease, genetic risk factors, APOE polymorphism, parkinsonism, disease severity, mitochondrial enzymes, oxidative stress, excitotoxicity, substantia nigra
- MeSH terms
- Apolipoproteins E, Blood Platelets, Brain, Energy Metabolism, Gene Frequency, Genetic Markers, Genotype, Humans, Mitochondria, Nerve Tissue Proteins, Parkinson Disease, Polymorphism, Genetic, Risk Factors, Cell Death, Oxidative Stress, Glutamic Acid, Genetic Predisposition to Disease, Synucleins, alpha-Synuclein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
