Nosocomial Cluster of Candida guillermondii Fungemia in Surgical Patients
Abstract
A nosocomial cluster of Candida guillermondii fungemia ( n=5 episodes) occurred in a surgical unit over a 2-week period. The five infected patients had received parenteral nutrition through central lines and three of them had catheter-related candidemia. All of the isolates were resistant to 5-flucytosine (MIC >32 microg/ml) and they had strictly related fingerprints, as generated by randomly amplified polymorphic DNA analysis. Although no isolate of Candida guillermondii was recovered from other clinical, surveillance or environmental samples, nosocomial spread of this yeast stopped following the reinforcement of infection control measures. Candida guillermondii may require an intravascular foreign body to cause fungemia, but the outbreak reported here shows that it can be transmitted nosocomially and cause epidemics.
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The Candida species found with Candida albicans in polymicrobial biofilms include Candida dubliniensis, Candida tropicalis, Candida parapsilosis, Candida guillermondii, Candida krusei, and Candida glabrata.
“These species include C. dubliniensis, C. tropicalis, C. parapsilosis, C. guillermondii, C. krusei, and C. glabrata (80, 90, 118, 151).”
From <i>Candida albicans</i> Biofilms and Human Disease (2015) · cites this paper as [118]
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- Authors
- Masala, L., Luzzati, R., Maccacaro, L., Antozzi, L., Concia, E., & Fontana, R.
- Affiliations
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
- University of Verona (IT)
- Corresponding author
- Luzzati, R.
- ORCID
- Luzzati, R.
- Venue
- European Journal of Clinical Microbiology & Infectious Diseases
- Published
- 2003-11-01
- Volume
- 22
- Issue
- 11
- Pages
- 686-688
- ISSN
- 0934-9723 (ISSN-L)
- 1435-4373
- OpenAlex
- W1973945716
- Cited by
- 42
- References
- 15
- Citations by year
- 2026: 3 · 2025: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 5 · 2012: 2
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Candida guilliermondii, fungemia, hospital outbreak, catheter-related candidemia, parenteral nutrition, central venous catheters, RAPD-PCR, infection control, surgical patients, fungal transmission
- MeSH terms
- Aged, Aged, 80 and over, Candida, Candidiasis, Cross Infection, Disease Outbreaks, Female, Humans, Italy, Male, Postoperative Complications, Risk Factors, Sampling Studies, Surgical Procedures, Operative, Incidence, Cluster Analysis, Fungemia
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