The DOI matches its Crossref record; 230 of the 230 references it cites were found in a registry or an index.
Mechanism of Candida pathogenesis: revisiting the vital drivers
Abstract
Candida is the most implicated fungal pathogen in the clinical setting. Several factors play important roles in the pathogenesis of Candida spp. Multiple transcriptional circuits, morphological and phenotypic switching, biofilm formation, tissue damaging extracellular hydrolytic enzymes, metabolic flexibility, genome plasticity, adaptation to environmental pH fluctuation, robust nutrient acquisition system, adherence and invasions (mediated by adhesins and invasins), heat shock proteins (HSPs), cytolytic proteins, escape from phagocytosis, evasion from host immune system, synergistic coaggregation with resident microbiota, resistance to antifungal agents, and the ability to efficiently respond to multiple stresses are some of the major pathogenic determinants of Candida species. The existence of multiple connections, in addition to the interactions and associations among all of these factors, are distinctive features that play important roles in the establishment of Candida infections. This review describes all the underlying factors and mechanisms involved in Candida pathogenesis by evaluating pathogenic determinants of Candida species. It reinforces the already available pool of data on the pathogenesis of Candida species by providing a clear and simplified understanding of the most important factors implicated in the pathogenesis of Candida species. The Candida pathogenesis network, an illustration linking all the major determinants of Candida pathogenesis, is also presented. Taken together, they will further improve our current understanding of how these factors modulate virulence and consequent infection(s). Development of new antifungal drugs and better therapeutic approaches to candidiasis can be achieved in the near future with continuing progress in the understanding of the mechanisms of Candida pathogenesis.
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“Indeed, frequent drug targets are the formation of hyphae, which is one of the first steps in biofilm formation, the enzymes aspartyl proteinases, key virulence factors able to degrade many human proteins (i.e., mucin, immune system molecules, endothelial cell proteins, and coagulation factors), and phospholipase enzymes, proteins able to break the ester bonds of phospholipids, inducing cell lysis”
From Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications (2021) · cites this paper as [89]
Citations
Cites
Items 201–230 of 230
Modulation of the Fungal-Host Interaction by the Intra-Species Diversity of C. albicans
Braunsdorf, C., & LeibundGut‐Landmann, S. (2018) · Pathogens · doi:10.3390/pathogens7010011 · Cited by 26
Maiti, P., Ghorai, P., Ghosh, S., Kamthan, M., Tyagi, R. K., & Datta, A. (2015) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2015.08.004 · Cited by 24
Hemolytic activities of the Candida species in liquid medium.
Malcok, H. K., Aktas, E., Ayyıldız, A., Yiğit, N., & Yazgı, H. (2009) · PubMed Central · Cited by 24
Changes in the hemolytic activity of Candida species by common electrolytes
Wan, L., Luo, G., Lu, H., Xuan, D., Cao, H., & Zhang, J. (2015) · BMC Microbiology · doi:10.1186/s12866-015-0504-7 · Cited by 23
Matos, T. G. F., Morais, F. V., & de Campos, C. B. L. (2012) · Medical Mycology · doi:10.3109/13693786.2012.725481 · Cited by 23
Phenotypic switch: The enigmatic white-gray-opaque transition system of Candida albicans
Bommanavar, S., Gugwad, S. C., & Malik, N. (2017) · Journal of Oral and Maxillofacial Pathology · doi:10.4103/0973-029x.203781 · Cited by 23
Alarmin(g) the innate immune system to invasive fungal infections
Caffrey, A. K., & Obar, J. J. (2016) · Current Opinion in Microbiology · doi:10.1016/j.mib.2016.06.002 · Cited by 22
Virulence Traits Contributing to Pathogenicity of Candida Species
Deorukhkar, S. C. (2017) · Journal of Microbiology & Experimentation · doi:10.15406/jmen.2017.05.00140 · Cited by 22
Bar-Yosef, H., Gildor, T., Ramírez-Zavala, B., Schmauch, C., Weissman, Z., Pinsky, M., Naddaf, R., Morschhäuser, J., Arkowitz, R., & Kornitzer, D. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00017 · Cited by 22
Hemoglobin is an effective inducer of hyphal differentiation inCandidaalbicans
Pendrak, M. L., & Roberts, D. D. (2006) · Medical Mycology · doi:10.1080/13693780601028691 · Cited by 21
Negri, M., Faria, M. G. I., Guilhermetti, E., Alves, A. A., Paula, C. R., & Svidzinski, T. I. E. (2010) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 21
Yiğit, N., & Aktas, E. (2009) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2009.03.005 · Cited by 20
Selection of orlistat as a potential inhibitor for lipase from Candida species
Benarous, K., & Abderrahman, L. (2011) · Bioinformation · doi:10.6026/97320630007125 · Cited by 19
Marotta, D. H., Nantel, A., Sukala, L., Teubl, J. R., & Rauceo, J. M. (2013) · Genomics · doi:10.1016/j.ygeno.2013.06.002 · Cited by 19
Isolation of Candida Species in clinical specimens and its virulence factor: The biofilm
Nerurkar, A. B., Solanky Priti, P., Chavda, N., Baria, H., & Desai, B. (2012) · International Journal of Medical Science and Public Health · doi:10.5455/ijmsph.2012.1.97-100 · Cited by 19
Ottilie, S., Goldgof, G. M., Cheung, A. L., Walker, J. L., Vigil, E., Allen, K. E., Antonova‐Koch, Y., Slayman, C. W., Suzuki, Y., & Durrant, J. D. (2018) · Journal of Cheminformatics · doi:10.1186/s13321-018-0261-3 · Cited by 19
Khoury, P. E., Awad, A., Wex, B., & Khalaf, R. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194403 · Cited by 17
Conrad, K. A., Rodriguez, R., Salcedo, E. C., & Rauceo, J. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192250 · Cited by 17
A Genome-Wide Transcriptional Analysis of Yeast-Hyphal Transition in Candida tropicalis by RNA-Seq
Wu, Y., Li, Y., Yu, S., Li, W., Liu, X.-S., Zhao, L. Q., & Lu, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166645 · Cited by 16
Sac7 and Rho1 regulate the white-to-opaque switching in Candida albicans
Yang, S. L., Zeng, G., Chan, F. Y., Wang, Y., Wang, Y., & Wang, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-19246-9 · Cited by 16
Genotypic analysis of secreted aspartyl proteinases in vaginal Candida albicans isolates
Lima, J. S., Braga, K. R. G. S., Vieira, C., de Souza, W. W. R., Chavez-Pavoni, J. H., de Araújo, C., & Goulart, L. (2018) · Jornal Brasileiro de Patologia e Medicina Laboratorial · doi:10.5935/1676-2444.20180006 · Cited by 16
Arslan, S., Koç, A. N., Şekerci, A. E., Tanrıverdi, F., Sav, H., Aydemir, G., & Diri, H. (2016) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1405-73 · Cited by 15
Targeting the Fungal Calcium–Calcineurin Signaling Network in Overcoming Drug Resistance
Li, X., & Sun, S. (2016) · Future Medicinal Chemistry · doi:10.4155/fmc-2016-0094 · Cited by 11
Kim, S., Nguyen, Q. B., Wolyniak, M. J., Frechette, G. M., Lehman, C. R., Fox, B. K., & Sundstrom, P. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192260 · Cited by 11
Nair, R., Khandelwal, N., Shariq, M., Redhu, A. K., Gaur, N. A., Shaikh, S., & Prasad, R. (2018) · AMB Express · doi:10.1186/s13568-018-0647-7 · Cited by 9
Calderone, R. (1998) · Trends in Microbiology · doi:10.1016/s0966-842x(98)01321-3 · Cited by 8
Ali, A., Azab, M., & Abdelrahman, A. A. (2018) · GSC Biological and Pharmaceutical Sciences · doi:10.30574/gscbps.2018.5.3.0149 · Cited by 8
Brown, A. J. P., Haynes, K., Gow, N. A. R., & Quinn, J. (2012) · Cited by 7
Padmajakshi., G., Saini, S., Deorukhkar, S. C., & Kandi, V. (2014) · American journal of microbiological research · doi:10.12691/ajmr-2-2-2 · Cited by 6
Bruno, D. D. C. F., Bartelli, T. F., Rodrigues, C. R., & Briones, M. R. S. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/168500 · Cited by 2
Research works printed but not linked: 8
- Correia A, Sampaio P, Vilanova M, Pais C (2015) Candida albicans: clinical relevance, pathogenesis, and host immunity. In: Sing SK (ed) Human emerging and re-emerging infections: viral and parasitic infections, vol 1. John Wiley and Sons, New Jersey, pp 926–952
- Kadosh D (2017) Morphogenesis in C. albicans. In: Prasad R (ed) Candida albicans: Cell Mol Biol. Springer, Cham
- Brown A, Haynes K, Gow N, Quinn J (2012) Stress responses in Candida, 2nd edn. ASM Press, Washington, D.C., pp 225–242
- Liu S, Liu W (2015) Components of the canclium-calcinerium signaling pathways in fungal cells and their potential as antifungal targets. Eukaryot Cell 14:4
- Shapiro RS, Uppuluri P, Zaas AK, Collins C, Senn H, Perfect JR et al (2009) Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis and drug resistance. PLoS ONE 7:e44734 · DOI · Paper page
- Sathiya T, Malar AS, Morthy K, Punitha T, Vinodhini R, Saranya AS (2015) Candida albicans and non albicans species: a study of biofilm production and putative virulence properties. JOHRP 4:164–175
- Jasim ST, Flayyih MT, Hassan A (2016) Isolation and identification of Candida spp. from different clinical specimens and study the virulence factors. World J Pharm Pharm Sci 3:121–137
- Bandana K, Jashandeep K, Jagdeep K (2018) Phospholipase in bacterial virulence and pathogenesis. Adv Biotechnol Microbiol 10:555798
Cited by
Sorted by citations
Lass‐Flörl, C., Kanj, S. S., Govender, N. P., Thompson, G. R., Ostrosky-Zeichner, L. L., & Govrins, M. A. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00503-3 · Cited by 345
Santus, W., Devlin, J. R., & Behnsen, J. (2021) · Infection and Immunity · doi:10.1128/iai.00648-20 · Cited by 142
El-Baz, A. M., Mosbah, R., Goda, R. M., Mansour, B., Sultana, T., Dahms, T. E. S., & El-Ganiny, A. M. (2021) · Antibiotics · doi:10.3390/antibiotics10010081 · Cited by 80
Gaziano, R., Sabbatini, S., & Monari, C. (2023) · Microorganisms · doi:10.3390/microorganisms11051211 · Cited by 84
What Do We Know about Candida auris? State of the Art, Knowledge Gaps, and Future Directions
García-Bustos, V., Cabañero-Navalón, M. D., Ruiz‐Saurí, A., Gaitán, A. C. R., Salavert, M., Tormo‐Más, M. Á., & Pemán, J. (2021) · Microorganisms · doi:10.3390/microorganisms9102177 · Cited by 83
Metadata
- Authors
- Mba, I. E., & Nweze, E. I.
- Affiliations
- University of Nigeria (NG)
- Corresponding author
- Nweze, Emeka Innocent
- Venue
- European Journal of Clinical Microbiology & Infectious Diseases
- Published
- 2020-05-06
- Volume
- 39
- Issue
- 10
- Pages
- 1797-1819
- ISSN
- 0934-9723 (ISSN-L)
- 1435-4373
- OpenAlex
- W3021920646
- Semantic Scholar
- 9a873a14a817c1928242b4ff3aa7bdb3341fc8f7
- Cited by
- 143
- References
- 230
- Citations by year
- 2026: 13 · 2025: 35 · 2024: 26 · 2023: 29 · 2022: 19 · 2021: 16 · 2020: 4
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- Candida, fungal pathogenesis, virulence factors, candidiasis, morphological switching, biofilm formation, extracellular hydrolytic enzymes, metabolic flexibility, genome plasticity, pH adaptation, nutrient acquisition, adhesins, invasin, heat shock proteins, cytolytic proteins, phagocytosis evasion, immune evasion, antifungal resistance, stress response
- MeSH terms
- Antifungal Agents, Candida, Candidiasis, Humans, Drug Resistance, Fungal, Virulence Factors
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