The DOI matches its Crossref record; 230 of the 230 references it cites were found in a registry or an index.
Mechanism of Candida pathogenesis: revisiting the vital drivers
Abstract
Candida is the most implicated fungal pathogen in the clinical setting. Several factors play important roles in the pathogenesis of Candida spp. Multiple transcriptional circuits, morphological and phenotypic switching, biofilm formation, tissue damaging extracellular hydrolytic enzymes, metabolic flexibility, genome plasticity, adaptation to environmental pH fluctuation, robust nutrient acquisition system, adherence and invasions (mediated by adhesins and invasins), heat shock proteins (HSPs), cytolytic proteins, escape from phagocytosis, evasion from host immune system, synergistic coaggregation with resident microbiota, resistance to antifungal agents, and the ability to efficiently respond to multiple stresses are some of the major pathogenic determinants of Candida species. The existence of multiple connections, in addition to the interactions and associations among all of these factors, are distinctive features that play important roles in the establishment of Candida infections. This review describes all the underlying factors and mechanisms involved in Candida pathogenesis by evaluating pathogenic determinants of Candida species. It reinforces the already available pool of data on the pathogenesis of Candida species by providing a clear and simplified understanding of the most important factors implicated in the pathogenesis of Candida species. The Candida pathogenesis network, an illustration linking all the major determinants of Candida pathogenesis, is also presented. Taken together, they will further improve our current understanding of how these factors modulate virulence and consequent infection(s). Development of new antifungal drugs and better therapeutic approaches to candidiasis can be achieved in the near future with continuing progress in the understanding of the mechanisms of Candida pathogenesis.
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“Indeed, frequent drug targets are the formation of hyphae, which is one of the first steps in biofilm formation, the enzymes aspartyl proteinases, key virulence factors able to degrade many human proteins (i.e., mucin, immune system molecules, endothelial cell proteins, and coagulation factors), and phospholipase enzymes, proteins able to break the ester bonds of phospholipids, inducing cell lysis”
From Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications (2021) · cites this paper as [89]
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Metadata
- Authors
- Mba, I. E., & Nweze, E. I.
- Affiliations
- University of Nigeria (NG)
- Corresponding author
- Nweze, Emeka Innocent
- Venue
- European Journal of Clinical Microbiology & Infectious Diseases
- Published
- 2020-05-06
- Volume
- 39
- Issue
- 10
- Pages
- 1797-1819
- ISSN
- 0934-9723 (ISSN-L)
- 1435-4373
- OpenAlex
- W3021920646
- Semantic Scholar
- 9a873a14a817c1928242b4ff3aa7bdb3341fc8f7
- Cited by
- 143
- References
- 230
- Citations by year
- 2026: 13 · 2025: 35 · 2024: 26 · 2023: 29 · 2022: 19 · 2021: 16 · 2020: 4
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- Candida, fungal pathogenesis, virulence factors, candidiasis, morphological switching, biofilm formation, extracellular hydrolytic enzymes, metabolic flexibility, genome plasticity, pH adaptation, nutrient acquisition, adhesins, invasin, heat shock proteins, cytolytic proteins, phagocytosis evasion, immune evasion, antifungal resistance, stress response
- MeSH terms
- Antifungal Agents, Candida, Candidiasis, Humans, Drug Resistance, Fungal, Virulence Factors
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