Candida albicans pathogenicity mechanisms

Mayer, François L.; Wilson, Duncan; Hube, Bernhard

doi:10.4161/viru.22913

Cited by 1,848Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Infections and Studies

Candida albicans pathogenicity mechanisms

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Mayer, François L., Wilson, Duncan, Hube, Bernhard·2013·Virulence

DOI 10.4161/viru.22913PMC PMC3654610

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Abstract

The polymorphic fungus Candida albicans is a member of the normal human microbiome. In most individuals, C. albicans resides as a lifelong, harmless commensal. Under certain circumstances, however, C. albicans can cause infections that range from superficial infections of the skin to life-threatening systemic infections. Several factors and activities have been identified which contribute to the pathogenic potential of this fungus. Among them are molecules which mediate adhesion to and invasion into host cells, the secretion of hydrolases, the yeast-to-hypha transition, contact sensing and thigmotropism, biofilm formation, phenotypic switching and a range of fitness attributes. Our understanding of when and how these mechanisms and factors contribute to infection has significantly increased during the last years. In addition, novel virulence mechanisms have recently been discovered. In this review we present an update on our current understanding of the pathogenicity mechanisms of this important human pathogen.

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The link between mitochondrial respiration and pathogenicity in C. albicans is well established.
“The link between mitochondrial respiration and pathogenicity in C. albicans is well established, and the capability of adapting cellular metabolism to different stress conditions is an important aspect of this connection (Mayer et al. 2013; Sun et al. 2019; Liu et al. 2023).”
From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as Mayer et al. 2013
The Metabolic adaptation section links metabolic flexibility and responses to changing host conditions with C. albicans virulence. It does not establish the more specific claimed link between mitochondrial respiration and pathogenicity; searches for mitochondrial respiration and the respiratory chain found no passage addressing it. (LLM, conf=0.87)
Experimental — accuracy not yet measured
The capability of adapting cellular metabolism to different stress conditions is an important aspect of the connection between mitochondrial respiration and pathogenicity in C. albicans.
“The link between mitochondrial respiration and pathogenicity in C. albicans is well established, and the capability of adapting cellular metabolism to different stress conditions is an important aspect of this connection (Mayer et al. 2013; Sun et al. 2019; Liu et al. 2023).”
From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as Mayer et al. 2013
The Metabolic adaptation section says that metabolic flexibility helps C. albicans withstand hostile host conditions and that adaptation to alternative nutrient sources can increase virulence. The Environmental stress response section also links stress adaptation to virulence. Neither section establishes the claimed connection specifically with mitochondrial respiration; the only mitochondrial mention found concerns a heat-shock protein, not respiration. Page numbers were unavailable in our copy. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Lipase activity has been detected and shown to be involved in the pathogenicity of yeasts such as Candida, Cryptococcus, or Malassezia species.
“Besides this, lipase activity has been detected and shown to be involved in the pathogenicity of yeasts such as Candida, Cryptococcus, or Malassezia species (Mayer et al. 2013; Park et al. 2013; Sommer et al. 2016).”
From Biocontrol yeasts: mechanisms and applications (2019) · cites this paper as Mayer et al. 2013
The “Secreted hydrolases” section reports that Candida albicans has secreted lipases and that a lipase-8 mutant had reduced virulence in a mouse model, supporting a role in pathogenicity. The cited paper does not establish the claim for Cryptococcus or Malassezia; the retrieved passages address Candida albicans only. (LLM, conf=0.88)
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THE HEAT-SHOCK RESPONSE
Lindquist, S. L. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.005443 · Cited by 4,611 · see citing works
Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem
Pfaller, M. A., & Diekema, D. J. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00029-06 · Cited by 4,174 · cited 2× · see citing works
“Indeed, Candida spp are the fourth most common cause of hospital-acquired systemic infections in the United States with crude mortality rates of up to 50%.(3,4) C.”
Background
Infectious Diseases Society of America
Enders, J. F. (1969) · The Journal of Infectious Diseases · doi:10.1093/infdis/119.3.317 · Cited by 3,305 · see citing works
Clinical Practice Guidelines for the Management Candidiasis: 2009 Update by the Infectious Diseases Society of America
Pappas, P. G., Kauffman, C. A., Andes, D., Benjamin, D. K., Calandra, T. F., Edwards, J. E., Filler, S. G., Fisher, J. F., Kullberg, B.-J., Zeichner, L. O., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/596757 · Cited by 3,191 · see citing works
How Many Species Are There on Earth and in the Ocean?
Mora, C., Tittensor, D. P., Adl, S., Simpson, A. G. B., & Worm, B. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001127 · Cited by 3,045 · see citing works
The Heat Shock Response: Life on the Verge of Death
Richter, K., Haslbeck, M., & Büchner, J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.006 · Cited by 2,045 · see citing works
Nonfilamentous C. albicans Mutants Are Avirulent
Lo, H.-J., Köhler, J. R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A., & Fink, G. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80358-x · Cited by 1,809 · see citing works
Nutritional immunity: transition metals at the pathogen–host interface
Hood, M. I., & Skaar, E. P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2836 · Cited by 1,535 · see citing works
Candida and candidosis
Odds, F. C. (1979) · Medical Entomology and Zoology · Cited by 1,292 · see citing works
Vulvovaginal candidosis
Sobel, J. D. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60917-9 · Cited by 1,270 · see citing works
Candida albicans Secreted Aspartyl Proteinases in Virulence and Pathogenesis
Naglik, J. R., Challacombe, S. J., & Hube, B. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.3.400-428.2003 · Cited by 1,179 · see citing works
Self-citation
Growth of Candida albicans hyphae
Sudbery, P. E. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2636 · Cited by 1,110 · see citing works
Quorum Sensing in the Dimorphic Fungus Candida albicans Is Mediated by Farnesol
Hornby, J. M., Jensen, E. C., Lisec, A. D., Tasto, J. J., Jahnke, B., Shoemaker, R., Dussault, P., & Nickerson, K. W. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.7.2982-2992.2001 · Cited by 983 · see citing works
Candida and candidiasis.
Calderone, R. (2012) · ASM Press eBooks · Cited by 919 · see citing works
Epidemiology of Invasive Mycoses in North America
Pfaller, M. A., & Diekema, D. J. (2010) · Critical Reviews in Microbiology · doi:10.3109/10408410903241444 · Cited by 901 · see citing works
The distinct morphogenic states of Candida albicans
Sudbery, P., Gow, N., & Berman, J. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.05.008 · Cited by 876 · see citing works
Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation
Sorger, P. K., & Pelham, H. R. B. (1988) · Cell · doi:10.1016/s0092-8674(88)91219-6 · Cited by 832 · see citing works
The glyoxylate cycle is required for fungal virulence
Lorenz, M. C., & Fink, G. R. (2001) · Nature · doi:10.1038/35083594 · Cited by 745 · see citing works
Nosocomial fungal infections: epidemiology, diagnosis, and treatment
Perlroth, J., Choi, B., & Spellberg, B. (2007) · Medical Mycology · doi:10.1080/13693780701218689 · Cited by 738 · see citing works
Transcriptional Response of Candida albicans upon Internalization by Macrophages
Lorenz, M. C., Bender, J. A., & Fink, G. R. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.5.1076-1087.2004 · Cited by 712 · see citing works
A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans
Nobile, C. J., Fox, E. P., Nett, J. E., Sorrells, T. R., Mitrovich, Q. M., Hernday, A. D., Tuch, B. B., Andes, D. R., & Johnson, A. D. (2012) · Cell · doi:10.1016/j.cell.2011.10.048 · Cited by 711 · see citing works
Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1.
Staab, J., Bradway, S. D., Fidel, P., & Sundstrom, P. (1999) · Science · doi:10.1126/science.283.5407.1535 · Cited by 683 · see citing works
Clinical Practice Guidelines for the Management of Candidiasis: 2009 Update by the Infectious Diseases Society of America
Parczewska, O. K., Posaconazol, przeciwgrzybicze, L., Anidulafungina, Micafungina, & wrażliwość, O. (2009) · Cited by 656 · see citing works
EngineeredControl of Cell Morphology In Vivo Reveals Distinct Roles for Yeast andFilamentous Forms of Candida albicans duringInfection
Saville, S. P., Lazzell, A. L., Monteagudo, C., & Lopez-Ribot, J. L. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.5.1053-1060.2003 · Cited by 655 · see citing works
Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells
Phan, Q. T., Myers, C. L., Fu, Y., Sheppard, D. C., Yeaman, M. R., Welch, W. H., Ibrahim, A. S., Edwards, J. E., & Filler, S. G. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050064 · Cited by 641 · see citing works
Tackling Human Fungal Infections
Brown, G. D., Denning, D. W., & Levitz, S. M. (2012) · Science · doi:10.1126/science.1222236 · Cited by 619 · see citing works
Genetic control of Candida albicans biofilm development
Finkel, J. S., & Mitchell, A. P. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2475 · Cited by 613 · see citing works
Flocculation, adhesion and biofilm formation in yeasts
Verstrepen, K. J., & Klis, F. M. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05072.x · Cited by 589 · see citing works
Candida albicans: A molecular revolution built on lessons from budding yeast
Berman, J., & Sudbery, P. E. (2002) · Nature Reviews Genetics · doi:10.1038/nrg948 · Cited by 578 · see citing works
α-Crystallin-Type Heat Shock Proteins: Socializing Minichaperones in the Context of a Multichaperone Network
Narberhaus, F. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.1.64-93.2002 · Cited by 534 · see citing works
Tyrosol is a quorum-sensing molecule in Candida albicans
Chen, H., Fujita, M., Feng, Q., Clardy, J., & Fink, G. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401416101 · Cited by 500 · see citing works
Fungal Biofilms
Fanning, S., & Mitchell, A. P. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002585 · Cited by 465 · see citing works
Hsp26: a temperature‐regulated chaperone
Haslbeck, M., Walke, S., Stromer, T., Ehrnsperger, M., White, H. E., Chen, S., Saibil, H. R., & Büchner, J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.23.6744 · Cited by 449 · see citing works
Dispersion as an Important Step in the Candida albicans Biofilm Developmental Cycle
Uppuluri, P., Chaturvedi, A. K., Srinivasan, A., Banerjee, M., Ramasubramaniam, A. K., Köhler, J. R., Kadosh, D., & Lopez-Ribot, J. L. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000828 · Cited by 432 · see citing works
Quorum sensing in fungi – a review
Albuquerque, P., & Casadevall, A. (2012) · Medical Mycology · doi:10.3109/13693786.2011.652201 · Cited by 431 · see citing works
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease
Cowen, L. E., Singh, S. D., Köhler, J. R., Collins, C., Zaas, A. K., Schell, W. A., Aziz, H., Mylonakis, E., Perfect, J. R., Whitesell, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813394106 · Cited by 413 · see citing works
Cellular interactions of Candida albicans with human oral epithelial cells and enterocytes
Dalle, F., Wächtler, B., L'ollivier, C., Holland, G., Bannert, N., Wilson, D., Labruère, C., Bonnin, A., & Hube, B. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01394.x · Cited by 366 · see citing works
Self-citation
The Fungal Pathogen Candida albicans Autoinduces Hyphal Morphogenesis by Raising Extracellular pH
Vylkova, S., Carman, A. J., Danhof, H. A., Collette, J. R., Zhou, H., & Lorenz, M. C. (2011) · mBio · doi:10.1128/mbio.00055-11 · Cited by 365 · see citing works
Candida albicans dimorphism as a therapeutic target
Jacobsen, I. D., Wilson, D., Wächtler, B., Brunke, S., Naglik, J. R., & Hube, B. (2012) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.11.152 · Cited by 363 · see citing works
Self-citation
Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin
Singh, S. D., Robbins, N., Zaas, A. K., Schell, W. A., Perfect, J. R., & Cowen, L. E. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000532 · Cited by 362 · see citing works
Mucosal damage and neutropenia are required for Candida albicans dissemination
Koh, A. Y., Köhler, J. R., Coggshall, K. T., Van Rooijen, N., & Pier, G. B. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.0040035 · Cited by 360 · see citing works
Complementary Adhesin Function in C. albicans Biofilm Formation
Nobile, C. J., Schneider, H. A., Nett, J. E., Sheppard, D. C., Filler, S. G., Andes, D. R., & Mitchell, A. P. (2008) · Current Biology · doi:10.1016/j.cub.2008.06.034 · Cited by 351 · see citing works
Role of the Mitogen-Activated Protein Kinase Hog1p in Morphogenesis and Virulence of Candida albicans
Alonso-Monge, R., Navarro-García, F., Molero, G., Diez-Orejas, R., Gustin, M., Pla, J., Sánchez, M., & Nombela, C. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.10.3058-3068.1999 · Cited by 344 · see citing works
Purification and characterization of a heat‐shock element binding protein from yeast.
Sorger, P. K., & Pelham, H. R. B. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02609.x · Cited by 340 · see citing works
Biofilm Matrix Regulation by Candida albicans Zap1
Nobile, C. J., Nett, J. E., Hernday, A. D., Homann, O. R., Deneault, J.-S., Nantel, A., Andes, D. R., Johnson, A. D., & Mitchell, A. P. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000133 · Cited by 337 · see citing works
Adhesion in Candida spp
Sundstrom, P. (2002) · Cellular Microbiology · doi:10.1046/j.1462-5822.2002.00206.x · Cited by 336 · see citing works
The Hyphal-Associated Adhesin and Invasin Als3 of Candida albicans Mediates Iron Acquisition from Host Ferritin
Almeida, R. S., Brunke, S., Albrecht, A., Thewes, S., Laue, M., Edwards, J. E., Filler, S. G., & Hube, B. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000217 · Cited by 330 · see citing works
Self-citation
PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90
LaFayette, S. L., Collins, C., Zaas, A. K., Schell, W. A., Betancourt-Quiroz, M., Gunatilaka, A. A. L., Perfect, J. R., & Cowen, L. E. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001069 · Cited by 329 · see citing works
Roles of the Candida albicans Mitogen-Activated Protein Kinase Homolog, Cek1p, in Hyphal Development and Systemic Candidiasis
Csank, C., Schröppel, K., Leberer, E., Harcus, D., Mohamed, O. A., Meloche, S., Thomas, D. Y., & Whiteway, M. S. (1998) · Infection and Immunity · doi:10.1128/iai.66.6.2713-2721.1998 · Cited by 329 · see citing works
Hgc1, a novel hypha‐specific G1 cyclin‐related protein regulates Candida albicans hyphal morphogenesis
Zheng, X., Wang, Y.-M., & Wang, Y. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600195 · Cited by 328 · see citing works
Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen
Ene, I. V., Adya, A. K., Wehmeier, S., Brand, A. C., MacCallum, D. M., Gow, N. A. R., & Brown, A. J. P. (2012) · Cellular Microbiology · doi:10.1111/j.1462-5822.2012.01813.x · Cited by 313 · see citing works
Hsp90 Orchestrates Temperature-Dependent Candida albicans Morphogenesis via Ras1-PKA Signaling
Shapiro, R. S., Uppuluri, P., Zaas, A. K., Collins, C., Senn, H., Perfect, J. R., Heitman, J., & Cowen, L. E. (2009) · Current Biology · doi:10.1016/j.cub.2009.03.017 · Cited by 311 · see citing works
Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence
Hube, B., Sanglard, D., Odds, F. C., Hess, D., Monod, M., Schäfer, W., Brown, A. J. P., & Gow, N. A. R. (1997) · Infection and Immunity · doi:10.1128/iai.65.9.3529-3538.1997 · Cited by 311 · see citing works
Self-citation
Identification and Characterization of TUP1-Regulated Genes in Candida albicans
Braun, B. R., Head, W. S., Wang, M. X., & Johnson, A. D. (2000) · Genetics · doi:10.1093/genetics/156.1.31 · Cited by 306 · see citing works
A Chaperone Pathway in Protein Disaggregation
Cashikar, A. G., Duennwald, M. L., & Lindquist, S. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502854200 · Cited by 293 · see citing works
Copper- and zinc-containing superoxide dismutase (Cu/ZnSOD) is required for the protection of Candida albicans against oxidative stresses and the expression of its full virulence
Hwang, C., Rhie, G., Oh, J., Huh, W., Yim, H., & Kang, S.-O. (2002) · Microbiology · doi:10.1099/00221287-148-11-3705 · Cited by 293 · see citing works
Hsp90 Governs Dispersion and Drug Resistance of Fungal Biofilms
Robbins, N., Uppuluri, P., Nett, J., Rajendran, R., Ramage, G., Lopez-Ribot, J. L., Andes, D., & Cowen, L. E. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002257 · Cited by 291 · see citing works
A Candida Biofilm-Induced Pathway for Matrix Glucan Delivery: Implications for Drug Resistance
Taff, H. T., Nett, J. E., Zarnowski, R., Ross, K. M., Sanchez, H., Cain, M. T., Hamaker, J., Mitchell, A. P., & Andes, D. R. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002848 · Cited by 291 · see citing works
Superoxide Dismutases in Candida albicans : Transcriptional Regulation and Functional Characterization of the Hyphal-induced SOD5 Gene
Martchenko, M., Alarco, A.-M., Harcus, D., & Whiteway, M. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-03-0179 · Cited by 290 · see citing works
In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination: C. albicans genes associated with oral candidiasis
Zakikhany, K., Naglik, J. R., Schmidt-Westhausen, A., Holland, G., Schaller, M., & Hube, B. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01009.x · Cited by 288 · see citing works
Self-citation
Candida albicans interactions with epithelial cells and mucosal immunity
Naglik, J. R., Moyes, D. L., Wächtler, B., & Hube, B. (2011) · Microbes and Infection · doi:10.1016/j.micinf.2011.06.009 · Cited by 277 · see citing works
Self-citation
Candida albicans RIM101 pH Response Pathway Is Required for Host-Pathogen Interactions
Davis, D. A., Edwards, J. E., Mitchell, A. P., & Ibrahim, A. S. (2000) · Infection and Immunity · doi:10.1128/iai.68.10.5953-5959.2000 · Cited by 276 · see citing works
From Attachment to Damage: Defined Genes of Candida albicans Mediate Adhesion, Invasion and Damage during Interaction with Oral Epithelial Cells
Wächtler, B., Wilson, D., Haedicke, K., Dalle, F., & Hube, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017046 · Cited by 270 · see citing works
Self-citation
Glycosylphosphatidylinositol-anchored Proteases of Candida albicans Target Proteins Necessary for Both Cellular Processes and Host-Pathogen Interactions
Albrecht, A., Felk, A., Pichova, I., Naglik, J. R., Schaller, M., de Groot, P., MacCallum, D., Odds, F. C., Schäfer, W., Klis, F., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509297200 · Cited by 270 · see citing works
Self-citation
Candida albicans cell surface superoxide dismutases degrade host‐derived reactive oxygen species to escape innate immune surveillance
Frohner, I. E., Bourgeois, C., Yatsyk, K., Majer, O., & Kuchler, K. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06528.x · Cited by 267 · see citing works
The MAP kinase signal transduction network in Candida albicans
Alonso‐Monge, R., Román, E., Nombela, C., & Plá, J. (2006) · Microbiology · doi:10.1099/mic.0.28616-0 · Cited by 263 · see citing works
The pH of the Host Niche Controls Gene Expression in and Virulence of Candida albicans
De Bernardis, F., Mühlschlegel, F. A., Cassone, A., & Fonzi, W. A. (1998) · Infection and Immunity · doi:10.1128/iai.66.7.3317-3325.1998 · Cited by 258 · see citing works
Systemic Fungal Infections Caused by Candida Species: Epidemiology, Infection Process and Virulence Attributes
Mavor, A., Thewes, S., & Hube, B. (2005) · Current Drug Targets · doi:10.2174/138945005774912735 · Cited by 252 · see citing works
Self-citation
Candida albicans-Epithelial Interactions: Dissecting the Roles of Active Penetration, Induced Endocytosis and Host Factors on the Infection Process
Wächtler, B., Citiulo, F., Jablonowski, N., Förster, S., Dalle, F., Schaller, M., Wilson, D., & Hube, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036952 · Cited by 250 · see citing works
Self-citation
Candida albicans Scavenges Host Zinc via Pra1 during Endothelial Invasion
Citiulo, F., Jacobsen, I. D., Miramón, P., Schild, L., Brunke, S., Zipfel, P., Brock, M., Hube, B., & Wilson, D. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002777 · Cited by 242 · see citing works
Self-citation
Cloning and Disruption of caPLB1, a Phospholipase B Gene Involved in the Pathogenicity of Candida albicans
Leidich, S. D., Ibrahim, A. S., Fu, Y., Koul, A., Jessup, C., Vitullo, J., Fonzi, W., Mirbod, F., Nakashima, S., Nozawa, Y., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.26078 · Cited by 241 · see citing works
A family of Candida cell surface haem‐binding proteins involved in haemin and haemoglobin‐iron utilization
Weissman, Z., & Kornitzer, D. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04199.x · Cited by 231 · see citing works
Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis
Schaller, M., Korting, H. C., Schäfer, W., Bastert, J., Chen, W., & Hube, B. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01590.x · Cited by 230 · see citing works
Self-citation
The Siderophore Iron Transporter ofCandida albicans(Sit1p/Arn1p) Mediates Uptake of Ferrichrome-Type Siderophores and Is Required for Epithelial Invasion
Heymann, P., Gerads, M., Schaller, M., Dromer, F., Winkelmann, G., & Ernst, J. F. (2002) · Infection and Immunity · doi:10.1128/iai.70.9.5246-5255.2002 · Cited by 226 · see citing works
Interactions ofCandida albicanswith epithelial cells
Zhu, W., & Filler, S. G. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01412.x · Cited by 223 · see citing works
Host Cell Invasion and Virulence Mediated by Candida albicans Ssa1
Sun, J. N., Solis, N. V., Phan, Q. T., Bajwa, J. S., Kashleva, H., Thompson, A., Liu, Y., Dongari-Bagtzoglou, A., Edgerton, M., & Filler, S. G. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001181 · Cited by 220 · see citing works
Secreted lipases of Candida albicans : cloning, characterisation and expression analysis of a new gene family with at least ten members
Hube, B., Stehr, F., Bossenz, M., Mazur, A., Kretschmar, M., & Schäfer, W. (2000) · Archives of Microbiology · doi:10.1007/s002030000218 · Cited by 212 · see citing works
Self-citation
PHR2 of Candida Albicans Encodes a Functional Homolog of the pH-regulated Gene PHR1 with an Inverted Pattern of pH-Dependent Expression
Mühlschlegel, F. A., & Fonzi, W. A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.10.5960 · Cited by 209 · see citing works
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Park, H., Myers, C. L., Sheppard, D. C., Phan, Q. T., Sanchez, A. A., E. Edwards, J., & Filler, S. G. (2004) · Cellular Microbiology · doi:10.1111/j.1462-5822.2004.00476.x · Cited by 207 · see citing works
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Wysong, D. R., Christin, L., Sugar, A. M., Robbins, P. W., & Diamond, R. D. (1998) · Infection and Immunity · doi:10.1128/iai.66.5.1953-1961.1998 · Cited by 201 · see citing works
Candida albicans iron acquisition within the host
Almeida, R. S., Wilson, D., & Hube, B. (2009) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2009.00570.x · Cited by 199 · see citing works
Self-citation
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Inglis, D. O., Arnaud, M. B., Binkley, J., Shah, P., Skrzypek, M. S., Wymore, F., Binkley, G., Miyasato, S. R., Simison, M., & Sherlock, G. J. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr945 · Cited by 194 · see citing works
PHR1 and PHR2 of Candida albicans Encode Putative Glycosidases Required for Proper Cross-Linking of β-1,3- and β-1,6-Glucans
Fonzi, W. A. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.22.7070-7079.1999 · Cited by 193 · see citing works
Transcriptional Response ofCandida albicansto Nitric Oxide and the Role of theYHB1Gene in Nitrosative Stress and Virulence
Hromatka, B. S., Noble, S. M., & Johnson, A. D. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-05-0435 · Cited by 183 · see citing works
How human pathogenic fungi sense and adapt to pH: the link to virulence
Davis, D. A. (2009) · Current Opinion in Microbiology · doi:10.1016/j.mib.2009.05.006 · Cited by 177 · see citing works
Targeting virulence: A new paradigm for antifungals
Gauwerky, K. J., Borelli, C., & Körting, H. C. (2009) · Drug Discovery Today · doi:10.1016/j.drudis.2008.11.013 · Cited by 174 · see citing works
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Brand, A., & Gow, N. A. R. (2009) · Current Opinion in Microbiology · doi:10.1016/j.mib.2009.05.007 · Cited by 170 · see citing works
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Li, X. S., Reddy, M. S., Baev, D., & Edgerton, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300680200 · Cited by 167 · see citing works
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Ghosh, S., Navarathna, D. H. M. L. P., Roberts, D. D., Cooper, J. T., Atkin, A. L., Petro, T. M., & Nickerson, K. W. (2009) · Infection and Immunity · doi:10.1128/iai.01452-08 · Cited by 165 · see citing works
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Brand, A., Shanks, S., Duncan, V. M. S., Yang, M., Mackenzie, K. S., & Gow, N. A. R. (2007) · Current Biology · doi:10.1016/j.cub.2006.12.043 · Cited by 154 · see citing works
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Kumamoto, C. A. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1960 · Cited by 153 · see citing works
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Nobile, C. J., Solis, N., Myers, C. L., Fay, A. J., Deneault, J.-S., Nantel, A., Mitchell, A. P., & Filler, S. G. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01198.x · Cited by 150 · see citing works
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Thewes, S., Kretschmar, M., Park, H., Schaller, M., Filler, S. G., & Hube, B. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05614.x · Cited by 140 · see citing works
Self-citation
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Soll, D. (2009) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2009.00562.x · Cited by 136 · see citing works
Heat-shock proteins and stress tolerance in microorganisms
Lindquist, S. L. (1992) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(05)80135-2 · Cited by 136 · see citing works
Secreted aspartic proteases are not required for invasion of reconstituted human epithelia by Candida albicans.
Lermann, U., & Morschhäuser, J. (2008) · Microbiology · doi:10.1099/mic.0.2008/022525-0 · Cited by 135 · see citing works
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Hall, R. A., Turner, K. J., Chaloupka, J., Cottier, F., Sordi, L. D., Sanglard, D., Levin, L. R., Buck, J., & Mühlschlegel, F. A. (2011) · Eukaryotic Cell · doi:10.1128/ec.05060-11 · Cited by 131 · see citing works
Candida vaginitis
Hurley, R., & de Louvois, J. (1979) · Postgraduate Medical Journal · doi:10.1136/pgmj.55.647.645 · Cited by 130 · see citing works
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Garcia, M. C., Lee, J. T., Ramsook, C. B., Alsteens, D., Dufrêne, Y., & Lipke, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017632 · Cited by 128 · see citing works
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Sundstrom, P., Cutler, J., & Staab, J. (2002) · Infection and Immunity · doi:10.1128/iai.70.6.3281-3283.2002 · Cited by 128 · see citing works
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Moran, G. P., Coleman, D. C., & Sullivan, D. J. (2011) · International Journal of Microbiology · doi:10.1155/2012/205921 · Cited by 127 · see citing works
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Murciano, C., Moyes, D., Runglall, M., Tobouti, P., Islam, A., Hoyer, L., & Naglik, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033362 · Cited by 124 · see citing works
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Diez‐Orejas, R., Molero, G., Navarro-García, F., Plá, J., Nombela, C., & Sánchez‐Pérez, M. (1997) · Infection and Immunity · doi:10.1128/iai.65.2.833-837.1997 · Cited by 120 · see citing works
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Brock, M. (2009) · Current Opinion in Microbiology · doi:10.1016/j.mib.2009.05.004 · Cited by 115 · see citing works
Candida albicans Biofilms Do Not Trigger Reactive Oxygen Species and Evade Neutrophil Killing
Xie, Z., Thompson, A. K., Sobue, T., Kashleva, H., Xu, H., Vasilakos, J. P., & Dongari‐Bagtzoglou, A. I. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis607 · Cited by 114 · see citing works
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Phan, Q. T., Fratti, R. A., Prasadarao, N. V., Edwards, J. E., & Filler, S. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412592200 · Cited by 113 · see citing works
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Eyles, S. J., & Gierasch, L. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915160107 · Cited by 112 · see citing works
Candida and Candidiasis
(2011) · ASM Press eBooks · doi:10.1128/9781555817176 · Cited by 110 · see citing works
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Fleck, C. B., Schöbel, F., & Brock, M. (2011) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2011.04.007 · Cited by 110 · see citing works
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Nicholls, S., MacCallum, D. M., Kaffarnik, F. A. R., Selway, L., Peck, S. C., & Brown, A. J. P. (2010) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2010.08.010 · Cited by 107 · see citing works
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Mayer, F. L., Wilson, D., Jacobsen, I. D., Miramón, P., Slesiona, S., Bohovych, I., Brown, A. J. P., & Hube, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038584 · Cited by 100 · see citing works
Self-citation
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Fu, Y., Ibrahim, A. S., Fonzi, W. A., Zhou, X., Ramos, C. F., & Ghannoum, M. A. (1997) · Microbiology · doi:10.1099/00221287-143-2-331 · Cited by 96 · see citing works
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Staib, P., & Morschhäuser, J. (2006) · Mycoses · doi:10.1111/j.1439-0507.2006.01308.x · Cited by 94 · see citing works
Frequency and Response to Vaginal Symptoms among White and African American Women: Results of a Random Digit Dialing Survey
Foxman, B., MARSH, J. V., Gillespie, B. W., & Sobel, J. D. (1998) · Journal of Women s Health · doi:10.1089/jwh.1998.7.1167 · Cited by 92 · see citing works
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Li, X. S., Sun, J. N., Okamoto‐Shibayama, K., & Edgerton, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604064200 · Cited by 90 · see citing works
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Niewerth, M., & Körting, H. C. (2001) · Mycoses · doi:10.1046/j.1439-0507.2001.00685.x · Cited by 86 · see citing works
Limited Role of Secreted Aspartyl Proteinases Sap1 to Sap6 in Candida albicans Virulence and Host Immune Response in Murine Hematogenously Disseminated Candidiasis
Correia, A., Lermann, U., Teixeira, L., Cerca, F., Botelho, A. S., da Costa, R. M. G., Sampaio, P., Gärtner, F., Morschhäuser, J., Vilanova, M., et al. (2010) · Infection and Immunity · doi:10.1128/iai.00248-10 · Cited by 86 · see citing works
History and new insights into host defense against vaginal candidiasis
Fidel, P. L. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.03.006 · Cited by 85 · see citing works
Regulation of Innate Immune Response toCandida albicansInfections by αMβ2-Pra1p Interaction
Soloviev, D. A., Jawhara, S., & Fonzi, W. A. (2011) · Infection and Immunity · doi:10.1128/iai.00650-10 · Cited by 82 · see citing works
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Brand, A., Vacharaksa, A., Bendel, C. M., Norton, J., Haynes, P. R., Henry‐Stanley, M. J., Wells, C. L., Ross, K., Gow, N. A. R., & Gale, C. A. (2008) · Eukaryotic Cell · doi:10.1128/ec.00453-07 · Cited by 71 · see citing works
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Marvin, M. E., WILLIAMS, P. H., & Cashmore, A. M. (2003) · Microbiology · doi:10.1099/mic.0.26172-0 · Cited by 67 · see citing works
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Leach, M. D., Stead, D., Argo, E., & Brown, A. J. P. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-07-0632 · Cited by 65 · see citing works
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Mayer, F. L., Wilson, D., Jacobsen, I. D., Miramón, P., Große, K., & Hube, B. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002592 · Cited by 61 · see citing works
Self-citation
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Cleary, I. A., Reinhard, S. M., Miller, C. L., Murdoch, C., Thornhill, M. H., Lazzell, A. L., Monteagudo, C. C., Thomas, D. P., & Saville, S. P. (2011) · Microbiology · doi:10.1099/mic.0.046326-0 · Cited by 55 · see citing works
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Sun, J. N., Li, W., Jang, W. S., Nayyar, N., Sutton, M. D., & Edgerton, M. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06480.x · Cited by 50 · see citing works
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Taylor, B., Hannemann, H., Sehnal, M., Biesemeier, A., Schweizer, A., Röllinghoff, M., & Schröppel, K. (2005) · Infection and Immunity · doi:10.1128/iai.73.10.7061-7063.2005 · Cited by 44 · see citing works
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Mitchell, B. M., Wu, T. G., Jackson, B. E., & Wilhelmus, K. R. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0793 · Cited by 38 · see citing works
Functional Characterization of the Small Heat Shock Protein Hsp12p from Candida albicans
Fu, M. S., Sordi, L. D., & Mühlschlegel, F. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042894 · Cited by 35 · see citing works
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Fiori, A., Kucharíková, S., Govaert, G., Cammue, B. P. A., Thevissen, K., & Dijck, P. V. (2012) · Eukaryotic Cell · doi:10.1128/ec.00147-12 · Cited by 33 · see citing works
The RIM101 Signal Transduction Pathway Regulates Candida albicans Virulence during Experimental Keratomycosis
Yuan, X., Mitchell, B. M., Hua, X., Davis, D. A., & Wilhelmus, K. R. (2010) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.09-4726 · Cited by 30 · see citing works
Stress Responses inCandida
Brown, A. J. P., Haynes, K., Gow, N. A. R., & Quinn, J. (2014) · ASM Press eBooks · doi:10.1128/9781555817176.ch15 · Cited by 16 · see citing works
Candida: What Should Clinicians and Scientists Be Talking About?
Spellberg, B. J., Marr, K. A., & Filler, S. G. (2014) · ASM Press eBooks · doi:10.1128/9781555817176.ch1 · Cited by 13 · see citing works

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Research works printed but not linked: 3

Ruhnke M. Skin and mucous membrane infections. In: Calderone RA, ed. Candida and Candidiasis: ASM Press, Washington, DC, pp. 307-325., 2002.
Zordan R, Cormack B. Adhesins on Opportunistic Fungal Pathogens. In: Calderone RA, Clancy, C.J., ed. Candida and Candidiasis: ASM Press, Washington, DC, pp 243-259, 2012.
Brown AJP, Haynes K, Gow NAR, Quinn J. Stress Responses in Candida . In: Calderone RA, Clancy, C.J., ed. Candida and Candidiasis: ASM Press, Washington, DC, pp. 225-242., 2012.

Sorted by citations

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“The transition from yeast to the hyphal form is a transition into a pathogenic form [22,23].”
Background
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Self-citation
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Xing, M., Cao, Q., Wang, Y., Han, X., Zhao, J., Zhang, Q., Ji, A., & Song, S. (2020) · Marine Drugs · doi:10.3390/md18030144 · Cited by 251 · see citing works
Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection
Witchley, J. N., Penumetcha, P. M., Abon, N. V., Woolford, C. A., Mitchell, A. P., & Noble, S. M. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.02.008 · Cited by 242 · see citing works
Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota
Hoefs, S., Mogavero, S., & Hube, B. (2016) · The Journal of Microbiology · doi:10.1007/s12275-016-5514-0 · Cited by 238 · see citing works
Self-citation
Candidalysin: discovery and function in Candida albicans infections
Naglik, J., Gaffen, S., & Hube, B. (2019) · Current Opinion in Microbiology · doi:10.1016/j.mib.2019.06.002 · Cited by 203 · see citing works
Self-citation
The gut, the bad and the harmless: Candida albicans as a commensal and opportunistic pathogen in the intestine
Kumamoto, C. A., Gresnigt, M. S., & Hube, B. (2020) · Current Opinion in Microbiology · doi:10.1016/j.mib.2020.05.006 · Cited by 208 · see citing works
Self-citation
Antibacterial and antifungal activity of chitosan coated iron oxide nanoparticles
Nehra, P., Chauhan, R., Garg, N., & Verma, K. K. (2017) · British Journal of Biomedical Science · doi:10.1080/09674845.2017.1347362 · Cited by 207 · see citing works
Antifungals discovery: an insight into new strategies to combat antifungal resistance
Fuentefría, A. M., Pippi, B., Lana, D. F. D., Donato, K., & de Andrade, S. F. (2017) · Letters in Applied Microbiology · doi:10.1111/lam.12820 · Cited by 207 · see citing works
Mechanisms of Antifungal Properties of Metal Nanoparticles
Slavin, Y. N., & Bach, H. (2022) · Nanomaterials · doi:10.3390/nano12244470 · Cited by 213 · see citing works
Inhibition of gold nanoparticles (AuNPs) on pathogenic biofilm formation and invasion to host cells
Yu, Q., Li, J., Zhang, Y., Wang, Y., Liu, L., & Li, M. (2016) · Scientific Reports · doi:10.1038/srep26667 · Cited by 203 · see citing works
The human gut mycobiome: pitfalls and potentials—a mycologist’s perspective
Haute, M. J. S. V., & Hallen‐Adams, H. E. (2015) · Mycologia · doi:10.3852/15-147 · Cited by 197 · see citing works
Development of the Human Mycobiome over the First Month of Life and across Body Sites
Ward, T., Domínguez-Bello, M. G., Heisel, T. J., Al‐Ghalith, G. A., Knights, D., & Gale, C. A. (2018) · mSystems · doi:10.1128/msystems.00140-17 · Cited by 198 · see citing works
Invasive candidiasis: current clinical challenges and unmet needs in adult populations
Soriano, À., Honoré, P. M., Puerta‐Alcalde, P., García‐Vidal, C., Pagotto, A., Gonçalves, D. C., & Verweij, P. E. (2023) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkad139 · Cited by 200 · see citing works
Breakthrough invasive fungal infections: Who is at risk?
Jenks, J. D., Cornely, O. A., Chen, S. C. ‐., Thompson, G. R., & Hoenigl, M. (2020) · Mycoses · doi:10.1111/myc.13148 · Cited by 191 · see citing works
The vaginal mycobiome: A contemporary perspective on fungi in women's health and diseases
Bradford, L. L., & Ravel, J. (2016) · Virulence · doi:10.1080/21505594.2016.1237332 · Cited by 188 · see citing works
Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits
Ciurea, C. N., Kosovski, I.-B., Mare, A. D., Toma, F., Pintea-Simon, I. A., & Man, A. (2020) · Microorganisms · doi:10.3390/microorganisms8060857 · Cited by 197 · see citing works
Candida Survival Strategies
Polke, M., Hube, B., & Jacobsen, I. D. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2014.12.002 · Cited by 188 · see citing works
Self-citation
Inkjet printing for pharmaceutical applications
Boehm, R. D., Miller, P. R., Daniels, J. W., Stafslien, S. J., & Narayan, R. J. (2014) · Materials Today · doi:10.1016/j.mattod.2014.04.027 · Cited by 184 · see citing works
Silver nanoparticles induced alterations in multiple cellular targets, which are critical for drug susceptibilities and pathogenicity in fungal pathogen (Candida albicans)
Radhakrishnan, V. S., Mudiam, M. K. R., Kumar, M., Dwivedi, S. P., Singh, S. P., & Prasad, T. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s150648 · Cited by 180 · see citing works
TargetingCandida albicansfilamentation for antifungal drug development
Vila, T., Romo, J. A., Pierce, C. G., McHardy, S. F., Saville, S. P., & Lopez-Ribot, J. L. (2017) · Virulence · doi:10.1080/21505594.2016.1197444 · Cited by 174 · see citing works
Metabolism in fungal pathogenesis
Ene, I. V., Brunke, S., Brown, A. J. P., & Hube, B. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019695 · Cited by 169 · see citing works
Self-citation
Nanotechnology in combating biofilm: A smart and promising therapeutic strategy
Mohanta, Y. K., Chakrabartty, I., Mishra, A. K., Chopra, H., Mahanta, S., Avula, S. K., Patowary, K., Ahmed, R., Mishra, B., Mohanta, T. K., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1028086 · Cited by 169 · see citing works
Candida albicans and Candida glabrata : global priority pathogens
Katsipoulaki, M., Stappers, M. H. T., Malavia, D., Brunke, S., Hube, B., & Gow, N. A. R. (2024) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00021-23 · Cited by 174 · see citing works
Self-citation
Fungal Morphogenetic Pathways Are Required for the Hallmark Inflammatory Response during Candida albicans Vaginitis
Peters, B. M., Palmer, G. E., Nash, A. K., Lilly, E. A., Fidel, P. L., & Noverr, M. C. (2013) · Infection and Immunity · doi:10.1128/iai.01417-13 · Cited by 165 · see citing works
Implementing CRISPR-Cas technologies in conventional and non-conventional yeasts: Current state and future prospects
Raschmanová, H., Weninger, A., Glieder, A., Kovar, K., & Vogl, T. J. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.01.006 · Cited by 164 · see citing works
Cross-Domain and Viral Interactions in the Microbiome
Rowan-Nash, A. D., Korry, B. J., Mylonakis, E. E., & Belenky, P. A. (2019) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00044-18 · Cited by 164 · see citing works
Interaction of Candida Species with the Skin
Kühbacher, A., Burger‐Kentischer, A., & Rupp, S. (2017) · Microorganisms · doi:10.3390/microorganisms5020032 · Cited by 161 · see citing works
Urinary tract infections and Candida albicans
Behzadi, P., Behzadi, E., & Ranjbar, R. (2015) · Editor-in-Chief s Voice List of Authors is an Important Element in a Scientific Publication · doi:10.5173/ceju.2015.01.474 · Cited by 157 · see citing works
Proteomics Unravels Extracellular Vesicles as Carriers of Classical Cytoplasmic Proteins in Candida albicans
Gil-Bona, A., Llama‐Palacios, A., Parra‐Giraldo, C. M., Vivanco, F., Nombela, C., Monteoliva, L., & Gil, C. (2014) · Journal of Proteome Research · doi:10.1021/pr5007944 · Cited by 151 · see citing works
Antimicrobial Compounds Produced by Vaginal Lactobacillus crispatus Are Able to Strongly Inhibit Candida albicans Growth, Hyphal Formation and Regulate Virulence-related Gene Expressions
Wang, S., Wang, Q., Yang, E., Yan, L., Li, T., & Zhuang, H. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00564 · Cited by 152 · see citing works
Morphological changes in response to environmental stresses in the fungal plant pathogen Zymoseptoria tritici
Francisco, C. S., Ma, X., Zwyssig, M. M., McDonald, B. A., & Palma‐Guerrero, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-45994-3 · Cited by 147 · see citing works
Mechanism of Candida pathogenesis: Revisiting the vital drivers
Mba, I. E., & Nweze, E. I. (2020) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-020-03912-w · Cited by 143 · see citing works
Effects of chlorhexidine mouthwash on the oral microbiome
Brookes, Z. L. S., Belfield, L., Ashworth, A., Casas‐Agustench, P., Raja, M., Pollard, A. J., & Bescós, R. (2021) · Journal of Dentistry · doi:10.1016/j.jdent.2021.103768 · Cited by 154 · see citing works
Candida albicans the main opportunistic pathogenic fungus in humans
Macias-Paz, I. U., Pérez-Hernández, S., Tavera-Tapia, A., Luna-Arias, J. P., Guerra-Cárdenas, J. E., & Reyna-Beltrán, E. (2023) · Revista Argentina de Microbiología · doi:10.1016/j.ram.2022.08.003 · Cited by 141 · see citing works
Longitudinal Survey of Fungi in the Human Gut: ITS Profiling, Phenotyping, and Colonization
Raimondi, S., Amaretti, A., Gozzoli, C., Simone, M., Righini, L., Candeliere, F., Brun, P., Ardizzoni, A., Colombari, B., Paulone, S., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01575 · Cited by 138 · see citing works
From Jekyll to Hyde: The Yeast–Hyphal Transition of Candida albicans
Chow, E. W. L., Pang, L. M., & Wang, Y. (2021) · Pathogens · doi:10.3390/pathogens10070859 · Cited by 144 · see citing works
Antibiotic-induced collateral damage to the microbiota and associated infections
de Nies, L., Kobras, C. M., & Stracy, M. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00936-9 · Cited by 145 · see citing works
Histological Observation and Expression Patterns of antimicrobial peptides during Fungal Infection in Musca domestica (Diptera: Muscidae) Larvae
Jiangfan, X., Wang, T., Wang, Y., Jianwei, W., Guo, G., Yingchun, Z., & Xiaoli, S. (2016) · Brazilian Archives of Biology and Technology · doi:10.1590/1678-4324-2016160147 · Cited by 137 · see citing works
Fungal persister cells: The basis for recalcitrant infections?
Wuyts, J., Van Dijck, P., & Holtappels, M. (2018) · PLOS Pathogens · doi:10.1371/journal.ppat.1007301 · Cited by 136 · see citing works
Activity of phenolic compounds from plant origin against Candida species
Martins, N. A., Barros, L., Henriques, M., Silva, S. M., & Ferreira, I. C. F. R. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2015.05.067 · Cited by 138 · see citing works
Portrait of Candida Species Biofilm Regulatory Network Genes
Araújo, D., Henriques, M., & Silva, S. M. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.09.004 · Cited by 135 · see citing works
Biofilms and vulvovaginal candidiasis
Rodríguez‐Cerdeira, C., Carnero-Gregorio, M., Molares-Vila, A., López-Bárcenas, A., Fabbrocini, G., Bardhi, B., Sinani, A., Sánchez-Blanco, E., Arenas, R., & Hernández‐Castro, R. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.11.011 · Cited by 154 · see citing works
Candida Auris, An Agent of Hospital-Associated Outbreaks: Which Challenging Issues Do We Need to Have in Mind?
Sabino, R., Veríssimo, C., Pereira, Á. A., & Antunes, F. (2020) · Microorganisms · doi:10.3390/microorganisms8020181 · Cited by 133 · see citing works
Comparative Phenotypic Analysis of the Major Fungal Pathogens Candida parapsilosis and Candida albicans
Holland, L., Schröder, M., Turner, S. A., Taff, H. T., Andes, D. R., Grózer, Z., Gácser, A., Ames, L., Haynes, K., Higgins, D. G., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004365 · Cited by 132 · see citing works
Defensins: antifungal lessons from eukaryotes
Silva, P. M. D. S., GonÃ§alves, S. N., & Santos, N. C. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00097 · Cited by 126 · see citing works
A novel small molecule inhibitor of Candida albicans biofilm formation, filamentation and virulence with low potential for the development of resistance
Pierce, C. G., Chaturvedi, A. K., Lazzell, A. L., Powell, A. T., Saville, S. P., McHardy, S. F., & Lopez-Ribot, J. L. (2015) · npj Biofilms and Microbiomes · doi:10.1038/npjbiofilms.2015.12 · Cited by 124 · see citing works
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management
Thompson, G. R., Jenks, J. D., Baddley, J. W., Lewis, J. S., Egger, M., Schwartz, I. S., Boyer, J., Patterson, T. F., Chen, S. C. ‐., Pappas, P. G., et al. (2023) · Clinical Microbiology Reviews · doi:10.1128/cmr.00019-23 · Cited by 128 · see citing works
Genomic factors shape carbon and nitrogen metabolic niche breadth across Saccharomycotina yeasts
Opulente, D. A., LaBella, A. L., Harrison, M.-C., Wolters, J. F., Liu, C., Li, Y., Kominek, J., Steenwyk, J. L., Stoneman, H. R., VanDenAvond, J., et al. (2024) · Science · doi:10.1126/science.adj4503 · Cited by 121 · see citing works
Iron at the Centre of Candida albicans Interactions
Fourie, R., Kuloyo, O. O., Mochochoko, B. M., Albertyn, J., & Pohl, C. H. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00185 · Cited by 118 · see citing works
Oral Candidosis: Pathophysiology and Best Practice for Diagnosis, Classification, and Successful Management
Lu, S.-Y. (2021) · Journal of Fungi · doi:10.3390/jof7070555 · Cited by 118 · see citing works
Candida albicans Hyphae: From Growth Initiation to Invasion
Desai, J. (2018) · Journal of Fungi · doi:10.3390/jof4010010 · Cited by 117 · see citing works
Essential Oil of Cymbopogon nardus (L.) Rendle: A Strategy to Combat Fungal Infections Caused by Candida Species
de Toledo, L. G., Ramos, M. A. D. S., Spósito, L., Castilho, E. M., Pavan, F. R., Lopes, É. O., Zocolo, G. J., Silva, F., Soares, T., dos Santos, A. G., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081252 · Cited by 120 · see citing works
The Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage
Wilson, D., Naglik, J. R., & Hube, B. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005867 · Cited by 117 · see citing works
Self-citation
Taxonomy of Allergenic Fungi
Levetin, E., Horner, W. E., Scott, J. A., Barnes, C. S., Baxi, S., Chew, G. L., Grimes, C., Horner, W. E., Kennedy, K., Larenas-Linnemann, D., et al. (2015) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2015.10.012 · Cited by 115 · see citing works
How Chemotherapy Increases the Risk of Systemic Candidiasis in Cancer Patients: Current Paradigm and Future Directions
Teoh, F., & Pavelka, N. (2016) · Pathogens · doi:10.3390/pathogens5010006 · Cited by 115 · see citing works
Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization
Westman, J., Moran, G. P., Mogavero, S., Hube, B., & Grinstein, S. (2018) · mBio · doi:10.1128/mbio.01226-18 · Cited by 112 · see citing works
Self-citation
Mitochondrial Activity and Cyr1 Are Key Regulators of Ras1 Activation of C. albicans Virulence Pathways
Grahl, N., Demers, E. G., Lindsay, A. K., Harty, C. E., Willger, S. D., Piispanen, A. E., & Hogan, D. A. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1005133 · Cited by 111 · see citing works
“Hyphal growth increases tissue adherence and penetration, as well as the formation of adherent biofilms on medical devices [6,25,26].”
Background
A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase
MacAlpine, J., Daniel-Ivad, M., Liu, Z., Yano, J., Revie, N. M., Todd, R. T., Stogios, P. J., Sánchez, H., O’Meara, T. R., Tompkins, T. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26390-w · Cited by 111 · see citing works
Vaginal lactobacilli inhibit growth and hyphae formation of Candida albicans
Jang, S. J., Lee, K., Kwon, B., You, H. J., & Ko, G. (2019) · Scientific Reports · doi:10.1038/s41598-019-44579-4 · Cited by 110 · see citing works
Development of Anti-Virulence Approaches for Candidiasis via a Novel Series of Small-Molecule Inhibitors of Candida albicans Filamentation
Romo, J. A., Pierce, C. G., Chaturvedi, A. K., Lazzell, A. L., McHardy, S. F., Saville, S. P., & Lopez-Ribot, J. L. (2017) · mBio · doi:10.1128/mbio.01991-17 · Cited by 109 · see citing works
Interspecies Interactions between Clostridium difficile and Candida albicans
van Leeuwen, P. T., van der Peet, J. M., Bikker, F. J., Hoogenkamp, M. A., Paiva, A. M. O., Kostidis, S., Mayboroda, O. A., Smits, W. K., & Krom, B. P. (2016) · mSphere · doi:10.1128/msphere.00187-16 · Cited by 107 · see citing works
Circuit diversification in a biofilm regulatory network
Huang, M. Y., Woolford, C. A., May, G. E., McManus, C. J., & Mitchell, A. P. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007787 · Cited by 102 · see citing works
Divergent Approaches to Virulence in C. albicans and C. glabrata: Two Sides of the Same Coin
Galocha, M., Pais, P., Cavalheiro, M., Pereira, D., Viana, R., & Teixeira, M. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092345 · Cited by 105 · see citing works
Honokiol induces reactive oxygen species-mediated apoptosis in Candida albicans through mitochondrial dysfunction
Sun, L., Liao, K., Hang, C., & Wang, D. (2017) · PLOS ONE · doi:10.1371/journal.pone.0172228 · Cited by 105 · see citing works
The glyoxylate cycle and alternative carbon metabolism as metabolic adaptation strategies of Candida glabrata: perspectives from Candida albicans and Saccharomyces cerevisiae
Chew, S. Y., Chee, W. J. Y., & Than, L. T. L. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0546-5 · Cited by 105 · see citing works
Synergistic antifungal effect of chitosan-stabilized selenium nanoparticles synthesized by pulsed laser ablation in liquids against Candida albicans biofilms
Lara, H. H., Guisbiers, G., Mendoza, J., Mimun, L. C., Vincent, B., Lopez-Ribot, J. L., & Nash, K. L. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s151285 · Cited by 104 · see citing works
Antimicrobial nano-silver non-woven polyethylene terephthalate fabric via an atmospheric pressure plasma deposition process
Deng, X., Nikiforov, A. Y., Coenye, T., Cools, P., Aziz, G., Morent, R., Geyter, N. D., & Leys, C. (2015) · Scientific Reports · doi:10.1038/srep10138 · Cited by 104 · see citing works
Activation and Alliance of Regulatory Pathways in C. albicans during Mammalian Infection
Xu, W., Solis, N. V., Ehrlich, R. L., Woolford, C. A., Filler, S. G., & Mitchell, A. P. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002076 · Cited by 103 · see citing works
Overview of carbon and nitrogen catabolite metabolism in the virulence of human pathogenic fungi
Ries, L. N. A., Beattie, S. R., Cramer, R. A., & Goldman, G. H. (2017) · Molecular Microbiology · doi:10.1111/mmi.13887 · Cited by 99 · see citing works
Host-pathogen interactions between the human innate immune system and Candida albicans—understanding and modeling defense and evasion strategies
Dühring, S., Germerodt, S., Skerka, C., Zipfel, P. F., Dandekar, T., & Schuster, S. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00625 · Cited by 104 · see citing works
Inhibitors of the Glyoxylate Cycle Enzyme ICL1 in Candida albicans for Potential Use as Antifungal Agents
Cheah, H.-L., Lim, V., & Sandai, D. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095951 · Cited by 103 · see citing works
Interplay between Candida albicans and Lactic Acid Bacteria in the Gastrointestinal Tract: Impact on Colonization Resistance, Microbial Carriage, Opportunistic Infection, and Host Immunity
Zeise, K. D., Woods, R. J., & Huffnagle, G. B. (2021) · Clinical Microbiology Reviews · doi:10.1128/cmr.00323-20 · Cited by 101 · see citing works
Modulation of Staphylococcus aureus Response to Antimicrobials by the Candida albicans Quorum Sensing Molecule Farnesol
Kong, E. F., Tsui, C., Kucharíková, S., Dijck, P. V., & Jabra‐Rizk, M. A. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01573-17 · Cited by 99 · see citing works
The birth of a deadly yeast: tracing the evolutionary emergence of virulence traits in Candida glabrata
Gabaldón, T., & Carreté, L. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fov110 · Cited by 99 · see citing works
Perspectives on how mucosal immune responses, infections and gut microbiome shape IgA nephropathy and future therapies
He, J., Zhou, S., Lv, J., & Zhang, H. (2020) · Theranostics · doi:10.7150/thno.49778 · Cited by 104 · see citing works

Authors: Mayer, F. L., Wilson, D., & Hube, B.
Affiliations: Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
Jena University Hospital (DE)
Corresponding author: Hube, Bernhard
ORCID: Mayer, François L.
Wilson, Duncan
Hube, Bernhard
Venue: Virulence
Publisher: Informa UK Limited
Published: 2013-02-15
Volume: 4
Issue: 2
Pages: 119-128
ISSN: 2150-5594 (ISSN-L)
2150-5608
DOI: 10.4161/viru.22913
PMC: PMC3654610
OpenAlex: W2144035662
Semantic Scholar: ea82d70b2925d03c8aa23ad612a18cdb8c6906ed
Cited by: 1,848
References: 136
Citations by year: 2026: 99 · 2025: 162 · 2024: 163 · 2023: 180 · 2022: 195 · 2021: 189 · 2020: 164 · 2019: 156 · 2018: 150 · 2017: 119 · 2016: 97 · 2015: 84 · 2014: 57 · 2013: 30
FWCI: 11.35
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
Locations: Virulence (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft (01EO1002)
Bundesministerium für Bildung und Forschung (01EO1002)
International Leibniz Research School for Microbial and Biomolecular Interactions
Leibniz-Gemeinschaft
Center for Sepsis Control and Care (BMBF 01EO1002, 01EO1002)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords: Candida albicans, fungal pathogenicity, virulence factors, host cell invasion, yeast-to-hypha transition, tactile sensing, thigmotropism, biofilm formation, phenotypic switching, commensal to pathogen transition, systemic candidiasis, superficial fungal infections
MeSH terms: Candida albicans, Candidiasis, Humans, Virulence Factors

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