The DOI matches its Crossref record; 260 of the 260 references it cites were found in a registry or an index.
Plasmid-mediated quinolone resistance: an update
Abstract
In 1998, the first plasmid-mediated gene involved in quinolone resistance (currently named qnrA1) was reported. Extra qnr-like plasmid-mediated genes (qnrB, qnrS, qnrC, qnrD) and their chromosomal homologues have also been characterized. These genes code for a pentapeptide repeat protein that protects type II topoisomerases from quinolones. Since then, there have been reports of two other plasmid-mediated resistance mechanisms: the modification of quinolones with a piperazinyl substituent by the acetyltransferase, Aac(6')-Ib-cr; and active efflux by QepA and OqxAB, pumps related to major facilitator superfamily (MFS) transporters. These genes have a wide geographic distribution (mainly in Enterobacteriaceae). Because of the difficulties of phenotypic detection of this type of resistance, its real prevalence is only partially known. One important point is that although these mechanisms cause only low-level resistance, they favor and complement the selection of other resistance mechanisms.
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“It is thought that this reduction in the DNA gyrase-DNA interaction decreases the opportunities of the quinolone molecule to form and stabilize the gyrase-cleaved DNA-quinolone complex that is lethal for the cell (55).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [55]
Citations
Cites
DNA Topoisomerases: Structure, Function, and Mechanism
Champoux, J. J. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.369 · Cited by 2,804
DNA gyrase, topoisomerase IV, and the 4-quinolones
Drlica, K., & Zhao, X. (1997) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.61.3.377-392.1997 · Cited by 1,272
Quinolone resistance from a transferable plasmid
Martínez-Martínez, L., Pascual, Á., & Jacoby, G. A. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07322-4 · Cited by 1,112
Self-citationFluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase
Robicsek, A. A., Strahilevitz, J., Jacoby, G. A., Macielag, M. J., Abbanat, D., Park, C. H., Bush, K., & Hooper, D. C. (2005) · Nature Medicine · doi:10.1038/nm1347 · Cited by 1,011
The worldwide emergence of plasmid-mediated quinolone resistance
Robicsek, A. A., Jacoby, G. A., & Hooper, D. C. (2006) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(06)70599-0 · Cited by 965
Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat
Strahilevitz, J., Jacoby, G. A., Hooper, D. C., & Robicsek, A. A. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00016-09 · Cited by 926
DNA gyrase, topoisomerase IV, and the 4-quinolones.
Drlica, K., & Zhao, X. (1997) · Microbiology and Molecular Biology Reviews · doi:10.1128/.61.3.377-392.1997 · Cited by 896
Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli
Yoshida, H., Bogaki, M., Nakamura, M., Yamanaka, L. M., & Nakamura, S. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.8.1647 · Cited by 777
1,8-Naphthyridine Derivatives. A New Class of Chemotherapeutic Agents
Lesher, G. Y., Froelich, E. J., Gruett, M. D., et al. (1962) · Journal of Medicinal Chemistry · doi:10.1021/jm01240a021 · Cited by 770
Prevalence in the United States of aac(6 ′ ) - Ib - cr Encoding a Ciprofloxacin-Modifying Enzyme
Park, C. H., Robicsek, A. A., Jacoby, G. A., Sahm, D. F., & Hooper, D. C. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00915-06 · Cited by 755
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Mechanisms of Antibiotic Resistance
Munita, J. M., & Arias, C. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0016-2015 · Cited by 2,782
Mechanism of Quinolone Action and Resistance
Aldred, K. J., Kerns, R. J., & Osheroff, N. (2014) · Biochemistry · doi:10.1021/bi5000564 · Cited by 1,282
Mechanisms of antibiotic resistance
Munita, J. M., & Arias, C. A. (2016) · Virulence Mechanisms of Bacterial Pathogens · doi:10.1128/9781555819286.ch17 · Cited by 421
Metadata
- Authors
- Rodríguez-Martínez, J. M., Velasco, C., Pascual, Á., Cano, M. E., Martínez-Martínez, L., Martínez-Martínez, L., & Pascual, Á.
- Affiliations
- Universidad de Sevilla (ES)
- Marqués de Valdecilla University Hospital (ES)
- Corresponding author
- Rodríguez-Martínez, José Manuel
- Velasco, Carmen
- Cano, María Eliecer
- Venue
- Journal of Infection and Chemotherapy
- Publisher
- Elsevier BV
- Published
- 2011
- Volume
- 17
- Issue
- 2
- Pages
- 149-182
- ISSN
- 1341-321X (ISSN-L)
- OpenAlex
- W1964492646
- Cited by
- 306
- References
- 260
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 15 · 2023: 8 · 2022: 25 · 2021: 15 · 2020: 19 · 2019: 14 · 2018: 21 · 2017: 22 · 2016: 33 · 2015: 19 · 2014: 28 · 2013: 28 · 2012: 26
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Infection and Chemotherapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- plasmid-mediated quinolone resistance, qnr genes, qnrA, qnrB, qnrS, qnrD, aac(6')-Ib-cr, qepA, oqxAB, major facilitator superfamily transporter, efflux pumps, Enterobacteriaceae, antibiotic resistance mechanisms, resistance prevalence
- MeSH terms
- Acetyltransferases, Anti-Bacterial Agents, Bacterial Proteins, Enterobacteriaceae, Enterobacteriaceae Infections, Humans, Microbial Sensitivity Tests, Plasmids, Quinolones, Prevalence, Drug Resistance, Bacterial
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