Renal morphology and function from childhood to adulthood in Turner syndrome
Abstract
Background Turner syndrome (TS) is a chromosomal disorder with various complications, including congenital anomaly of the kidney and urinary tract (CAKUT). However, its renal function remains poorly known. Therefore, this study aimed to evaluate renal function in TS of various ages from childhood to adulthood.Methods We retrospectively analyzed 63 patients with TS who visited our hospital between 1989 and 2020, examined their renal morphology, and analyzed renal function by calculating the estimated glomerular filtration rate (eGFR) using formulas applicable for Japanese populations.Results Renal morphological abnormality was observed in 22 cases (35.0%) (horseshoe kidney, 7 [11.1%]; hydronephrosis, 11 [17.5%]; duplex collecting system, 3 [4.8%]; and single unilateral kidney, 1 [1.6%]). We evaluated the eGFR of 47 subjects aged 2.8-39.3 years and classified them into Group 1 (with CAKUT, n = 15) and Group 2 (without CAKUT, n = 32). The eGFR at the first visit and the final follow-up was not statistically different between these groups. In Group 1 with CAKUT, the eGFR was not significantly different between that at the first visit and that at the final follow-up (p = 0.21). During the observation period (median, 7.9 years), the eGFR of all individuals in both groups gradually decreased with age, but did not fall < 60 mL/min/1.73 m 2, which defines chronic kidney disease (CKD).Conclusions The renal function of TS remained normal in all cases during our investigation period, and no one developed CKD by the age of 40 years.
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Another study reported no change in successive eGFR measurements over time in girls with or without renal anomalies.
“Another study reported no change in successive eGFR measurements over time in girls with or without renal anomalies.686”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [686]
Congenital anomalies of the kidney and urinary tract are common in TS, with highly variable reported occurrence rates ranging between 18% and 60%.
“Congenital anomalies of the kidney and urinary tract are common in TS, with highly variable reported occurrence rates ranging between 18% and 60%.683-686”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [686]
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Clinical practice guidelines for the care of girls and women with Turner syndrome.
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- Authors
- Ogawa, T., Takizawa, F., Mukoyama, Y., Ogawa, A., & Ito, J.
- Affiliations
- Toranomon Hospital (JP)
- Corresponding author
- Ogawa, Tetsushi
- Venue
- Clinical and Experimental Nephrology
- Published
- 2021-02-22
- Volume
- 25
- Issue
- 6
- Pages
- 633-640
- ISSN
- 1342-1751 (ISSN-L)
- 1437-7799
- OpenAlex
- W3130038240
- Cited by
- 10
- References
- 29
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 1 · 2022: 1
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical and Experimental Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Urology and Nephrology Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- Turner syndrome, renal morphology, renal function, estimated glomerular filtration rate, horseshoe kidney, hydronephrosis, duplex collecting system, solitary kidney, chronic kidney disease, age-related decline in renal function
- MeSH terms
- Adolescent, Adult, Age Factors, Child, Child, Preschool, Female, Glomerular Filtration Rate, Humans, Japan, Kidney, Prognosis, Retrospective Studies, Turner Syndrome, Urogenital Abnormalities, Vesico-Ureteral Reflux, Disease Progression, Young Adult
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