The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Clinical outcome of a headache-specific multidisciplinary treatment program and adherence to treatment recommendations in a tertiary headache center: an observational study
Open accessAbstract
This study investigated the outcome of a 5-day headache-specific multidisciplinary treatment program (MTP) and the adherence to treatment recommendations in 295 prospectively recruited consecutive headache patients [210 migraine, 17 tension-type headache (TTH), 68 combination headache, including 56 medication-overuse headache (MOH)]. Headache frequency decreased from 13.4 (±8.8) to 8.8 (±8.0) days per month after 12-18 months. Forty-three percent of the participants fulfilled the primary outcome (reduction of headache frequency of ≥50%), which was less likely in patients with combination of migraine and TTH compared to migraine (OR = 3.136, p = 0.002) or TTH (OR = 1.029, n.s.). Increasing number of headache days per month (OR = 1.092, p ≤ 0.0001) and adherence to lifestyle modifications (OR = 1.269, p = 0.004) predicted primary outcome. 51 of 56 MOH patients were treated successfully. Thirty-five percent of the patients were adherent to pharmacological prophylaxis, 61% to relaxation therapy, and 72% to aerobic endurance sports. MTP is effective in headache treatment. Adherence to therapy was associated with better outcome.
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“A person-centered approach that integrates various intervention components is more effective [28,29] and may enhance personal control and efficacy in headache management [14].”
From Development and Evaluation of a Smartphone-Based Chatbot Coach to Facilitate a Balanced Lifestyle in Individuals With Headaches (BalanceUP App): Randomized Controlled Trial (2024) · cites this paper as [28]
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Citations
Cites
The International Classification of Headache Disorders: 2nd edition
Olesen, J., Goadsby, P. J., & Steiner, T. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00590-8 · Cited by 5,046
The global burden of headache: A documentation of headache prevalence and disability worldwide
Stovner, L., Hagen, K., Jensen, R., Katsarava, Z., Lipton, R., Scher, A., Steiner, T., & Zwart, J.-A. (2007) · Cephalalgia · doi:10.1111/j.1468-2982.2007.01288.x · Cited by 2,444 · cited 1×
“Primary headaches, in particular migraine and tensiontype headache (TTH) cause severe burden of disease and create high costs in the health care system [1, 2].”
BackgroundSelf-citationOlesen, J. (2004) · Cephalalgia · doi:10.1111/j.1468-2982.2003.00824.x · Cited by 2,056
Interventions for enhancing medication adherence
Haynes, R. B., Ackloo, E., Sahota, N., McDonald, H. P., & Yao, X. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011.pub3 · Cited by 1,244 · cited 1×
“Increasing the effectiveness of adherence might have more substantial impact on clinical outcome than improvement in specific medical treatments [27].”
Guidelines for Controlled Trials of Prophylactic Treatment of Chronic Migraine in Adults
Silberstein, S. D., Tfelt‐Hansen, P. C., Dodick, D., Limmroth, V., Lipton, R. B., Pascual, J., & Wang, S. J. (2008) · Cephalalgia · doi:10.1111/j.1468-2982.2008.01555.x · Cited by 303
Bigal, M., Rapoport, A., Sheftell, F., Tepper, S., & Lipton, R. (2004) · Cephalalgia · doi:10.1111/j.1468-2982.2004.00691.x · Cited by 275 · cited 1×
“Overuse of acute medication is responsible for the development or maintenance of chronic daily headache (CDH) and successful detoxification results in a 70% return to an episodic pattern of migraine [19].”
BackgroundClinical features, pathophysiology, and treatment of medication-overuse headache
Evers, S., & Marziniak, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70008-9 · Cited by 233 · cited 2×
“Longitudinal studies in academic headache clinics reported relapse rates from 30 to 41% 1 year after initial outpatient withdrawal treatment in MOH [5–8].”
BackgroundMedication Overuse Headache: Rates and Predictors for Relapse in a 4-year Prospective Study
Katsarava, Z., Muessig, M., Dzagnidze, A., Fritsche, G., Diener, H., & Limmroth, V. (2004) · Cephalalgia · doi:10.1111/j.1468-2982.2004.00789.x · Cited by 226 · cited 2×
“Longitudinal studies in academic headache clinics reported relapse rates from 30 to 41% 1 year after initial outpatient withdrawal treatment in MOH [5–8].”
BackgroundSelf-citationHolroyd, K. A., & Penzien, D. B. (1990) · Pain · doi:10.1016/0304-3959(90)91085-w · Cited by 223
Behavioral Management of Recurrent Headache: Three Decades of Experience and Empiricism
Penzien, D. B., Rains, J. C., & Andrasik, F. (2002) · Applied Psychophysiology and Biofeedback · doi:10.1023/a:1016247811416 · Cited by 162 · cited 1×
“The prophylactic effect of relaxation training in headache treatment is already proven in several studies [21–23].”
ResultSjögren, T., Nissinen, K. J., Järvenpää, S. K., Ojanen, M. T., Vanharanta, H. V., & Mälkiä, E. (2005) · Pain · doi:10.1016/j.pain.2005.03.031 · Cited by 136 · cited 1×
“We also observed effectiveness of aerobic endurance sports even though the level of evidence coming from clinical trials is still weak [24, 25].”
BackgroundGrande, R. B., Aaseth, K., Benth, J. Š., Lundqvist, C., & Russell, M. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2010.03094.x · Cited by 135 · cited 1×
“Notably, only two of 109, respectively, 18 of 80 patients used prophylactic medication [28].”
BackgroundHealthcare Resource Use and Costs Associated with Migraine in a Managed Healthcare Setting
Clouse, J., & Osterhaus, J. T. (1994) · Annals of Pharmacotherapy · doi:10.1177/106002809402800518 · Cited by 123 · cited 1×
“Primary headaches, in particular migraine and tensiontype headache (TTH) cause severe burden of disease and create high costs in the health care system [1, 2].”
BackgroundEfficacy of Multidisciplinary Treatment in a Tertiary Referral Headache Centre
Zeeberg, P., Olesen, J., & Jensen, R. (2005) · Cephalalgia · doi:10.1111/j.1468-2982.2005.00980.x · Cited by 119 · cited 3×
“[15], whose patients show higher adherence.”
BackgroundMethodInfluentialExercise in Migraine Therapy—Is There Any Evidence for Efficacy? A Critical Review
Busch, V., & Gaul, C. (2008) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2007.01045.x · Cited by 117 · cited 1×
“We also observed effectiveness of aerobic endurance sports even though the level of evidence coming from clinical trials is still weak [24, 25].”
BackgroundSelf-citationUse of Complementary and Alternative Medicine in Patients Suffering from Primary Headache Disorders
Gaul, C., Eismann, R., Schmidt, T., May, A., Leinisch, E., Wieser, T., Evers, S., Henkel, K., Franz, G., & Zierz, S. (2009) · Cephalalgia · doi:10.1111/j.1468-2982.2009.01841.x · Cited by 110 · cited 1×
“The unsatisfying adherence to medical treatment is a result of side effects and the general wish of headache patients ‘not to take a permanent medication,’ which was also found in 40% of the patients in other tertiary headache centers [26].”
BackgroundSelf-citationPrevention of medication overuse in patients with migraine
Fritsche, G., Frettlöh, J., Hüppe, M., Dlugaj, M., Matatko, N., Gaul, C., & Diener, H.-C. (2010) · Pain · doi:10.1016/j.pain.2010.07.032 · Cited by 88 · cited 1×
“This supports our psychological and educational concept focusing on MOH, which showed efficacy in a recently published randomized trial in behavioral management sessions as well as in so-called bibliotherapy [20].”
BackgroundSelf-citationThe Headache Management Trial: A Randomized Study of Coordinated Care
Matchar, D. B., Harpole, L. H., Samsa, G. P., Jurgelski, A. E., Lipton, R. B., Silberstein, S. D., Young, W. B., Kori, S. H., & Blumenfeld, A. M. (2008) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2007.01148.x · Cited by 71 · cited 1×
“Therefore, multidisciplinary treatment approaches (MTP) were established during the past decade in a few academic headache centers around the world [9, 10].”
BackgroundHeadache Management Program Improves Outcome for Chronic Headache
Harpole, L. H., Samsa, G. P., Jurgelski, A. E., Shipley, J. L., BERNSTEIN, A. L., & Matchar, D. B. (2003) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.2003.03128.x · Cited by 70 · cited 2×
“The percentage of patients with a reduction of at least 50% in headache frequency was not calculated [13].”
BackgroundEffectiveness of an Intensive Multidisciplinary Headache Treatment Program
Gunreben-Stempfle, B., Grießinger, N., Lang, E., Mühlhans, B., Sittl, R., & Ulrich, K. (2009) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2009.01448.x · Cited by 69 · cited 1×
“[17].”
Predictors of outcome of the treatment programme in a multidisciplinary headache centre
Jensen, R., Zeeberg, P., Dehlendorff, C., & Olesen, J. (2010) · Cephalalgia · doi:10.1177/0333102410361403 · Cited by 67 · cited 1×
“[9] report outcome data of MOH in a multidisciplinary headache center.”
BackgroundRains, J. C., Lipchik, G. L., & Penzien, D. B. (2006) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2006.00581.x · Cited by 57 · cited 2×
“Adherence to prophylactic treatment is a known problem in headache care, and factors influencing adherence to treatment in headache prophylaxis are still unclear and under debate [11, 12].”
BackgroundComprehensive/Tertiary Care for Headache: A 6‐Month Outcome Study
Saper, J. R., Lake, A. E., Madden, S. F., & Kreeger, C. (1999) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.1999.3904249.x · Cited by 52 · cited 2×
“Longitudinal studies in academic headache clinics reported relapse rates from 30 to 41% 1 year after initial outpatient withdrawal treatment in MOH [5–8].”
BackgroundEffectiveness of a Multidisciplinary Treatment Program for Chronic Daily Headache
Magnusson, J. E., Riess, C. M., & Becker, W. J. (2004) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100002869 · Cited by 47 · cited 1×
“[18] compared pharmacological therapy to a multidisciplinary treatment program for patients with transformed migraine and MOH in a controlled prospective study.”
BackgroundMongini, F., Ciccone, G., Rota, E., Ferrero, L., Ugolini, A., Evangelista, A., Ceccarelli, M., & Galassi, C. (2008) · Cephalalgia · doi:10.1111/j.1468-2982.2008.01551.x · Cited by 40 · cited 1×
“The prophylactic effect of relaxation training in headache treatment is already proven in several studies [21–23].”
ResultKatsarava, Z., Holle, D., & Diener, H. (2009) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-009-0019-4 · Cited by 33
Self-citationChronic Daily Headache with Medication Overuse: A Randomized Follow-Up by Neurologist or PCP
Bøe, M., Salvesen, R., & Mygland, Å. (2009) · Cephalalgia · doi:10.1111/j.1468-2982.2008.01810.x · Cited by 28
Influence of disease features on adherence to prophylactic migraine medication
Linde, M., Jonsson, P., & Hedenrud, T. (2008) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2008.01042.x · Cited by 27 · cited 2×
“characteristics nor any of the disease-specific variables were significantly associated with adherence [12].”
BackgroundLang, E., Kastner, S., Neundörfer, B., & Bickel, A. (2001) · Der Schmerz · doi:10.1007/s004820100053 · Cited by 10
Medication overuse and chronic migraine
Martin, V. T. (2009) · Current Pain and Headache Reports · doi:10.1007/s11916-009-0068-z · Cited by 2 · cited 1×
“Usually MOH is treated by withdrawal from the overused drugs [4].”
Background
Cited by
Sorted by citations
Systematic Review of Migraine Prophylaxis Adherence and Persistence
Hepp, Z., Bloudek, L. M., & Varon, S. F. (2014) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2014.20.1.22 · Cited by 334
Ashina, S., Mitsikostas, D. D., Lee, M. J., Yamani, N., Wang, S., Messina, R., Ashina, H., Buse, D. C., Pozo‐Rosich, P., Jensen, R., et al. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00257-2 · Cited by 290
Self-citationPathophysiology, prevention, and treatment of medication overuse headache
Diener, H., Dodick, D. W., Evers, S., Holle, D., Jensen, R., Lipton, R. B., Porreca, F., Silberstein, S. D., & Schwedt, T. J. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30146-2 · Cited by 226
Self-citationLuedtke, K., Allers, A., Schulte, L. H., & May, A. (2015) · Cephalalgia · doi:10.1177/0333102415597889 · Cited by 232
Kaiser, U., Sabatowski, R., & Azad, S. C. (2015) · Der Schmerz · doi:10.1007/s00482-015-0030-4 · Cited by 160
Metadata
- Authors
- Gaul, C., van Doorn, C., Webering, N., Dlugaj, M., Katsarava, Z., Diener, H.-C., & Fritsche, G.
- Affiliations
- Essen University Hospital (DE)
- Corresponding author
- Gaul, Charly
- Venue
- The Journal of Headache and Pain
- Published
- 2011-05-05
- Volume
- 12
- Issue
- 4
- Pages
- 475-483
- ISSN
- 1129-2369 (ISSN-L)
- 1129-2377
- PMC
- PMC3139052
- OpenAlex
- W2017444456
- Cited by
- 156
- References
- 30
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 14 · 2021: 7 · 2020: 8 · 2019: 13 · 2018: 13 · 2017: 12 · 2016: 6 · 2015: 13 · 2014: 17 · 2013: 8 · 2012: 10
- FWCI
- 8.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- The Journal of Headache and Pain (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Health Sciences › Dentistry › Oral Surgery › Temporomandibular Joint Disorders
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Keywords
- migraine, tension-type headache, medication overuse headache, medication adherence, headache frequency, lifestyle modification, pharmacological prophylaxis, relaxation training, headache centers
- MeSH terms
- Adolescent, Adult, Aged, Exercise Therapy, Female, Headache, Humans, Male, Middle Aged, Patient Compliance, Relaxation Therapy, Treatment Outcome, Pain Clinics, Young Adult
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