The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
miRNA-202 in bone marrow stromal cells affects the growth and adhesion of multiple myeloma cells by regulating B cell-activating factor
Abstract
Bone marrow stromal cells (BMSCs) up-regulate B cell-activating factor (BAFF) in multiple myeloma. Increasing experimental evidence has shown that microRNAs play a causal role in hematology tumorigenesis. In this study, we characterized the role of miR-202 in regulating the expression of BAFF in BMSCs. It was found that expressions of BAFF mRNA and protein were increased in BMSCs treated with miR-202 inhibitor. The growth rate of miR-202 mimics transfection cells was significantly lower than that of non-transfected cells. The expression of Bcl-2 protein was down-regulated, and Bax protein was up-regulated after miR-202 mimics transfection. Over-expression of miR-202 in BMSCs rendered MM cells more sensitive to bortezomib. More significantly, the regulatory effect of miR-202 could inhibit the activation of NF-κB pathway in BMSCs. These results suggest that miR-202 functions as a modulator that can negatively regulate BAFF by inhibiting MM cell survival, growth, and adhesion in the bone marrow microenvironment.
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“It is commonly known that miRNAs interfere with target genes, signaling molecules, and pathways within the context of the BM microenvironment, hence contributing to the pathogenesis of MM [167–169].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [167]
Citations
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MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis
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Research works printed but not linked: 1
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Cited by
Cheng, Q., Li, X., Wang, Y., Dong, M., Zhan, F., & Liu, J. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.118 · Cited by 104
Roles of miRNA dysregulation in the pathogenesis of multiple myeloma
Chen, D., Yang, X., Liu, M., Zhang, Z., & Xing, E. (2021) · Cancer Gene Therapy · doi:10.1038/s41417-020-00291-4 · Cited by 82
MicroRNAs and exosomes: Small molecules with big actions in multiple myeloma pathogenesis
Pourhanifeh, M. H., Mahjoubin‐Tehran, M., Shafiee, A., Hajighadimi, S., Moradizarmehri, S., Mirzaei, H., & Asemi, Z. (2019) · IUBMB Life · doi:10.1002/iub.2211 · Cited by 61
MicroRNAs: Novel Crossroads between Myeloma Cells and the Bone Marrow Microenvironment
Raimondi, L., Luca, A. D., Morelli, E., Giavaresi, G., Tagliaferri, P., Tassone, P., & Amodio, N. (2016) · BioMed Research International · doi:10.1155/2016/6504593 · Cited by 56
The diagnostic and prognostic value of plasma microRNA‑125b‑5p in patients with multiple myeloma
Jiang, Y., Luan, Y., Chang, H., & Chen, G. (2018) · Oncology Letters · doi:10.3892/ol.2018.9128 · Cited by 36
Metadata
- Authors
- Shen, X., Guo, Y., Yu, J., Qi, J., Shi, W., Wu, X., Ni, H., & Ju, S.
- Affiliations
- Affiliated Hospital of Nantong University (CN)
- Nantong University (CN)
- Soochow University (CN)
- Corresponding author
- Ju, Shaoqing
- Venue
- Clinical and Experimental Medicine
- Published
- 2015-05-14
- Volume
- 16
- Issue
- 3
- Pages
- 307-316
- ISSN
- 1591-8890 (ISSN-L)
- 1591-9528
- OpenAlex
- W222231233
- Cited by
- 37
- References
- 27
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 1 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 3 · 2015: 2
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Clinical and Experimental Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- The National Natural Science Foundation of China (81271920, 81301498)
- Jiangsu Provincial Program for Medical Innovation Teams and Leading Talents (LJ201133)
- Scientific Research Subject of Jiangsu Province Health Department (H201422)
- Six Major Human Resources Project of Jiangsu Province (20012-WS-119)
- Translational Medicine Project of Affiliated Hospital of Nantong University (TDF-zh201407)
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Hematology › Chronic Lymphocytic Leukemia Research
- Keywords
- miR-202, mesenchymal stem cells, multiple myeloma, B-cell activating factor, BAFF, microRNA, cell adhesion, cell growth, Bcl-2, Bax, NF-κB signaling, bone marrow microenvironment, tumor cell survival
- MeSH terms
- Aged, B-Lymphocytes, Cell Adhesion, Female, Humans, Male, Middle Aged, Multiple Myeloma, Cyclins, Gene Expression Profiling, MicroRNAs, Cell Proliferation, bcl-2-Associated X Protein, B-Cell Activating Factor, Mesenchymal Stem Cells
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- CoChat. (2026). Citation check: miRNA-202 in bone marrow stromal cells affects the growth and adhesion of multiple myeloma cells by regulating B cell-activating factor. https://app.cochat.ai/papers/10.1007/s10238-015-0355-4
- The paper
- Shen, X., Guo, Y., Yu, J., Qi, J., Shi, W., Wu, X., Ni, H., & Ju, S. (2016). miRNA-202 in bone marrow stromal cells affects the growth and adhesion of multiple myeloma cells by regulating B cell-activating factor. Clinical and Experimental Medicine. https://doi.org/10.1007/s10238-015-0355-4
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