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Sweat testing to evaluate autonomic function
Open accessAbstract
Sudomotor dysfunction is common in many subtypes of neuropathy but is one of the earliest detectable neurophysiologic abnormalities in distal small fiber neuropathy. Clinical assessments of sudomotor function include thermoregulatory sweat testing (TST), quantitative sudomotor axon reflex testing (QSART), silicone impressions, the sympathetic skin response (SSR), the acetylcholine sweat-spot test and quantitative direct and indirect axon reflex testing (QDIRT). These testing techniques, when used in combination, can detect and localize pre- and postganglionic lesions, can provide early diagnosis of sudomotor dysfunction and can monitor disease progression or disease recovery. In this article, we describe many of the common clinical tests available for evaluation of sudomotor function with focus on the testing methodology and limitations while providing concrete examples of test results.
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“Sweat testing has historically been used in applications ranging from medical diagnosis of cystic fibrosis and autonomic neuropathy to assessment of fluid and electrolyte balance in endurance athletes (6–10).”
From Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat (2019) · cites this paper as [7]
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Cites
A NEW PROGNOSTIC CLASSIFICATION OF RECTAL CANCER
Jass, J. R., Love, S., & Northover, J. M. A. (1987) · The Lancet · doi:10.1016/s0140-6736(87)90552-6 · Cited by 701
Shahani, B. T., HALPERIN, J. J., Boulu, P., & Cohen, J. (1984) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.47.5.536 · Cited by 602
Quantitative sudomotor axon reflex test in normal and neuropathic subjects
Low, P. A., Caskey, P. E., Tuck, R. R., Fealey, R. D., & Dyck, P. J. B. (1983) · Annals of Neurology · doi:10.1002/ana.410140513 · Cited by 491
Vetrugno, R., Liguori, R., Cortelli, P., & Montagna, P. (2003) · Clinical Autonomic Research · doi:10.1007/s10286-003-0107-5 · Cited by 475
(2013) · Acta Neurologica Belgica · doi:10.1007/13760.2240-2993 · Cited by 462
Sympathetic reflex latencies and conduction velocities in normal man
Fagius, J., & Wallin, B. G. (1980) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(80)90098-2 · Cited by 366
Thermoregulatory Sweating Abnormalities in Diabetes Mellitus
Fealey, R. D., Low, P. A., & Thomas, J. E. (1989) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)65338-5 · Cited by 274
Testing the Autonomic Nervous System
Low, P. A. (2003) · Seminars in Neurology · doi:10.1055/s-2004-817725 · Cited by 244
Detection of small‐fiber neuropathy by sudomotor testing
Low, V. A., Sandroni, P., Fealey, R. D., & Low, P. A. (2006) · Muscle & Nerve · doi:10.1002/mus.20551 · Cited by 227
Clinical autonomic disorders : evaluation and management
Low, P. A. (1997) · Cited by 202
Polyvinyl siloxane impression materials: An update on clinical use
Mandikos, M. N. (1998) · Australian Dental Journal · doi:10.1111/j.1834-7819.1998.tb00204.x · Cited by 193
Peripheral autonomic surface potential
Knezevic, W., & Bajada, S. (1985) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(85)90120-0 · Cited by 177
Clinical Autonomic Disorders: Evaluation and Management
Streeten, D. H. P. (1998) · Mayo Clinic Proceedings · doi:10.4065/73.11.1126-a · Cited by 169
Sympathetic skin response: normal results in different experimental conditions
Elie, B., & Guihéneuc, P. (1990) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(90)90020-k · Cited by 169
Hypothalamic mechanisms in thermoregulation.
Boulant, J. (1981) · PubMed · Cited by 166
Thermoregulation in spinal man
Guttmann, L., Silver, J., & Wyndham, C. H. (1958) · The Journal of Physiology · doi:10.1113/jphysiol.1958.sp006026 · Cited by 147
Regional and Individual Variations in the Function of the Human Eccrine Sweat Gland
Sato, K., & Dobson, R. L. (1970) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12259272 · Cited by 147
Uncini, A., Pullman, S. L., Lovelace, R. E., & Gambi, D. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90254-7 · Cited by 145
Evaluation of sudomotor function
Low, P. A. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.01.023 · Cited by 143
Quantitation of the sweating deficiency in diabetes mellitus
Kennedy, W. R., Sakuta, M., Sutherland, D. E. R., & Goetz, F. C. (1984) · Annals of Neurology · doi:10.1002/ana.410150514 · Cited by 127
Autonomic surface potential analysis: Assessment of reproducibility and sensitivity
Hoeldtke, R. D., Davis, K. M., Hshieh, P., Gaspar, S. R., & Dworkin, G. E. (1992) · Muscle & Nerve · doi:10.1002/mus.880150810 · Cited by 93
THE PSYCHO-GALVANIC REFLEX: A PHARMACOLOGICAL STUDY OF THE PERIPHERAL MECHANISM
Lader, M., & Montagu, J. D. (1962) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.25.2.126 · Cited by 92
Combining skin conductance and forced choice in the detection of concealed information
Meijer, E. H., Smulders, F. T. Y., Johnston, J. E., & Merckelbach, H. L. G. J. (2007) · Psychophysiology · doi:10.1111/j.1469-8986.2007.00543.x · Cited by 91
Dawson, M. E., Rissling, A. J., Schell, A. M., & Wilcox, R. R. (2007) · Emotion · doi:10.1037/1528-3542.7.4.755 · Cited by 87
Thermoregulation and Fever in Normal Persons and in Those With Spinal Cord Injuries
Schmidt, K. D., & CHAN, C. W. (1992) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)60394-2 · Cited by 87
RELATION OF ELECTRICAL PROPERTIES OF SKIN TO STRUCTURE AND PHYSIOLOGIC STATE
Edelberg, R. (1977) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12507771 · Cited by 85
Gibbons, C. H., Illigens, B. M. W., Centi, J., & Freeman, R. L. (2008) · Neurology · doi:10.1212/01.wnl.0000314646.49565.c0 · Cited by 67
Self-citationKihara, M., Opfer‐Gehrking, T. L., & Low, P. A. (1993) · Muscle & Nerve · doi:10.1002/mus.880160612 · Cited by 62
Low, P. A., Fealey, R. D., Sheps, S. G., Su, W. P. D., Trautmann, J. C., & Kuntz, N. L. (1985) · Annals of Neurology · doi:10.1002/ana.410180312 · Cited by 58
ACETYLCHOLINE SWEATSPOT TEST FOR AUTONOMIC DENERVATION
Ryder, R. E. J., Johnson, K., Owens, D. R., Marshall, R., Ryder, A., & Tm, H. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92120-4 · Cited by 56
Linden, D., & Berlit, P. (1995) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1995.tb07023.x · Cited by 55
The sweating deficiency in diabetes mellitus
Kennedy, W. R., Sakuta, M., Sutherland, D. E. R., & Goetz, F. C. (1984) · Neurology · doi:10.1212/wnl.34.6.758 · Cited by 54
Sympathetic skin response differentiates hereditary sensory autonomic neuropathies III and IV
Hilz, M. J., Stemper, B., & Axelrod, F. B. (1999) · Neurology · doi:10.1212/wnl.52.8.1652 · Cited by 50
New silicones for the evaluation of sudomotor function with the impression mold technique
Vilches, J., & Navarro, X. (2002) · Clinical Autonomic Research · doi:10.1007/s102860200006 · Cited by 49
Splanchnic preganglionic neurons in man
Low, P. A., Okazaki, H., & Dyck, P. J. B. (1977) · Acta Neuropathologica · doi:10.1007/bf00688573 · Cited by 47
Chemically and electrically induced sweating and flare reaction
Namer, B., Bickel, A., Krämer, H., Birklein, F., & Schmelz, M. (2004) · Autonomic Neuroscience · doi:10.1016/j.autneu.2004.06.007 · Cited by 43
Berghoff, M., Kilo, S., Hilz, M. J., & Freeman, R. L. (2006) · Muscle & Nerve · doi:10.1002/mus.20497 · Cited by 31
The evaluation of small fiber function—autonomic and quantitative sensory testing
Gibbons, C. H., & Freeman, R. L. (2004) · Neurologic Clinics · doi:10.1016/j.ncl.2004.03.002 · Cited by 29
Self-citationStewart, J. D., Nguyen, D. M., & Abrahamowicz, M. (1994) · Muscle & Nerve · doi:10.1002/mus.880171205 · Cited by 28
Low, P. A., & Dyck, P. J. (1977) · Acta Neuropathologica · doi:10.1007/bf00691957 · Cited by 25
III. Morphometry of Myelinated Fibers of Rami Communicantes
Low, P. A., & Dyck, P. J. B. (1978) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197811000-00002 · Cited by 21
Caccia, M. R., Dezuanni, E., SALVAGGIO, A., Osio, M., Bevilacqua, M. T., Norbiato, G., & Mangoni, A. (1991) · PubMed · Cited by 13
Knezevic, W., & Bajada, S. (1985) · PubMed · Cited by 11
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Posada-Quintero, H. F., & Chon, K. H. (2020) · Sensors · doi:10.3390/s20020479 · Cited by 525
Nyein, H. Y. Y., Bariya, M., Kivimäki, L., Uusitalo, S., Liaw, T. S., Jansson, E., Ahn, C. H., Hangasky, J. A., Zhao, J., Lin, Y., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw9906 · Cited by 388
Thermoregulatory disorders and illness related to heat and cold stress
Cheshire, W. P. (2016) · Autonomic Neuroscience · doi:10.1016/j.autneu.2016.01.001 · Cited by 353
Sudoscan, a Noninvasive Tool for Detecting Diabetic Small Fiber Neuropathy and Autonomic Dysfunction
CASELLINI, C. M., Parson, H. K., Richardson, M. S., Névoret, M. L., & Vinik, A. I. (2013) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2013.0129 · Cited by 324
Basics of autonomic nervous system function
(2019) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-64032-1.00027-8 · Cited by 233
Self-citation
Metadata
- Authors
- Illigens, B. M. W., & Gibbons, C. H.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Venue
- Clinical Autonomic Research
- Published
- 2008-11-06
- Volume
- 19
- Issue
- 2
- Pages
- 79-87
- ISSN
- 0959-9851 (ISSN-L)
- 1619-1560
- PMC
- PMC3046462
- OpenAlex
- W2155748720
- Cited by
- 255
- References
- 43
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 20 · 2023: 31 · 2022: 18 · 2021: 20 · 2020: 16 · 2019: 16 · 2018: 11 · 2017: 18 · 2016: 18 · 2015: 10 · 2014: 13 · 2013: 13 · 2012: 9
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Clinical Autonomic Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (K23NS050209)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Peripheral Nerve Disorders
- Health Sciences › Medicine › Dermatology › Sympathectomy and Hyperhidrosis Treatments
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Keywords
- sweat test, sudomotor dysfunction, autonomic function, thermoregulatory sweat test, sympathetic skin response, small fiber neuropathy, disease progression monitoring
- MeSH terms
- Acetylcholine, Diagnostic Techniques, Neurological, Humans, Peripheral Nervous System Diseases, Reflex, Sweat, Sweating
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