The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Sweat testing to evaluate autonomic function
Open accessAbstract
Sudomotor dysfunction is common in many subtypes of neuropathy but is one of the earliest detectable neurophysiologic abnormalities in distal small fiber neuropathy. Clinical assessments of sudomotor function include thermoregulatory sweat testing (TST), quantitative sudomotor axon reflex testing (QSART), silicone impressions, the sympathetic skin response (SSR), the acetylcholine sweat-spot test and quantitative direct and indirect axon reflex testing (QDIRT). These testing techniques, when used in combination, can detect and localize pre- and postganglionic lesions, can provide early diagnosis of sudomotor dysfunction and can monitor disease progression or disease recovery. In this article, we describe many of the common clinical tests available for evaluation of sudomotor function with focus on the testing methodology and limitations while providing concrete examples of test results.
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“Sweat testing has historically been used in applications ranging from medical diagnosis of cystic fibrosis and autonomic neuropathy to assessment of fluid and electrolyte balance in endurance athletes (6–10).”
From Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat (2019) · cites this paper as [7]
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Cites
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Quantitative sudomotor axon reflex test in normal and neuropathic subjects
Low, P. A., Caskey, P. E., Tuck, R. R., Fealey, R. D., & Dyck, P. J. B. (1983) · Annals of Neurology · doi:10.1002/ana.410140513 · Cited by 491
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(2013) · Acta Neurologica Belgica · doi:10.1007/13760.2240-2993 · Cited by 462
Sympathetic reflex latencies and conduction velocities in normal man
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Thermoregulatory Sweating Abnormalities in Diabetes Mellitus
Fealey, R. D., Low, P. A., & Thomas, J. E. (1989) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)65338-5 · Cited by 274
Testing the Autonomic Nervous System
Low, P. A. (2003) · Seminars in Neurology · doi:10.1055/s-2004-817725 · Cited by 244
Detection of small‐fiber neuropathy by sudomotor testing
Low, V. A., Sandroni, P., Fealey, R. D., & Low, P. A. (2006) · Muscle & Nerve · doi:10.1002/mus.20551 · Cited by 227
Clinical autonomic disorders : evaluation and management
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Nyein, H. Y. Y., Bariya, M., Kivimäki, L., Uusitalo, S., Liaw, T. S., Jansson, E., Ahn, C. H., Hangasky, J. A., Zhao, J., Lin, Y., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw9906 · Cited by 388
Thermoregulatory disorders and illness related to heat and cold stress
Cheshire, W. P. (2016) · Autonomic Neuroscience · doi:10.1016/j.autneu.2016.01.001 · Cited by 353
Sudoscan, a Noninvasive Tool for Detecting Diabetic Small Fiber Neuropathy and Autonomic Dysfunction
CASELLINI, C. M., Parson, H. K., Richardson, M. S., Névoret, M. L., & Vinik, A. I. (2013) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2013.0129 · Cited by 324
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Self-citation
Metadata
- Authors
- Illigens, B. M. W., & Gibbons, C. H.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Venue
- Clinical Autonomic Research
- Published
- 2008-11-06
- Volume
- 19
- Issue
- 2
- Pages
- 79-87
- ISSN
- 0959-9851 (ISSN-L)
- 1619-1560
- PMC
- PMC3046462
- OpenAlex
- W2155748720
- Cited by
- 255
- References
- 43
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 20 · 2023: 31 · 2022: 18 · 2021: 20 · 2020: 16 · 2019: 16 · 2018: 11 · 2017: 18 · 2016: 18 · 2015: 10 · 2014: 13 · 2013: 13 · 2012: 9
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Clinical Autonomic Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (K23NS050209)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Peripheral Nerve Disorders
- Health Sciences › Medicine › Dermatology › Sympathectomy and Hyperhidrosis Treatments
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Keywords
- sweat test, sudomotor dysfunction, autonomic function, thermoregulatory sweat test, sympathetic skin response, small fiber neuropathy, disease progression monitoring
- MeSH terms
- Acetylcholine, Diagnostic Techniques, Neurological, Humans, Peripheral Nervous System Diseases, Reflex, Sweat, Sweating
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