The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Drug discovery from natural products
Open accessAbstract
Natural product compounds are the source of numerous therapeutic agents. Recent progress to discover drugs from natural product sources has resulted in compounds that are being developed to treat cancer, resistant bacteria and viruses and immunosuppressive disorders. Many of these compounds were discovered by applying recent advances in understanding the genetics of secondary metabolism in actinomycetes, exploring the marine environment and applying new screening technologies. In many instances, the discovery of a novel natural product serves as a tool to better understand targets and pathways in the disease process. This review describes recent progress in drug discovery from natural sources including several examples of compounds that inhibit novel drug targets.
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Citations
Cites
Natural products as sources of new drugs over the period 1981–2002
Newman, D. J., Cragg, G. M., & Snader, K. M. (2003) · Journal of Natural Products · doi:10.1021/np030096l · Cited by 3,082
HSP90 and the chaperoning of cancer
Whitesell, L., & Lindquist, S. L. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1716 · Cited by 2,502
The role of natural product chemistry in drug discovery
Butler, M. S. (2004) · Journal of Natural Products · doi:10.1021/np040106y · Cited by 1,381
The influence of natural products upon drug discovery (Antiquity to late 1999)
Newman, D. J., Cragg, G. M., & Snader, K. M. (2000) · Natural Product Reports · doi:10.1039/a902202c · Cited by 1,293
Chauhan, D., Catley, L., Li, G., Podar, K., Hideshima, T., Velankar, M., Mitsiades, C., Mitsiades, N., Yasui, H., Letai, A., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.013 · Cited by 694
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
Kung, A. L., Zabludoff, S. D., France, D. S., Freedman, S. J., Tanner, E. A., Vieira, A., Cornell-Kennon, S., Lee, J., Wang, B., Wang, J., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.009 · Cited by 480
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Metadata
- Authors
- Gullo, V. P., McAlpine, J., Lam, K. S., Baker, D., & Petersen, F.
- Venue
- Journal of Industrial Microbiology & Biotechnology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-03-17
- Volume
- 33
- Issue
- 7
- Pages
- 523-531
- ISSN
- 1367-5435 (ISSN-L)
- 1476-5535
- OpenAlex
- W2047941302
- Cited by
- 222
- References
- 6
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Drug discovery from natural products. https://app.cochat.ai/papers/10.1007/s10295-006-0107-2
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- Gullo, V. P., McAlpine, J., Lam, K. S., Baker, D., & Petersen, F. (2006). Drug discovery from natural products. Journal of Industrial Microbiology & Biotechnology. https://doi.org/10.1007/s10295-006-0107-2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
