The role of natural product chemistry in drug discovery

The druggable genome

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Natural products as sources of new drugs over the period 1981–2002

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Methods in Molecular Biology

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Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery

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The influence of natural products upon drug discovery (Antiquity to late 1999)

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A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

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The Process of Structure-Based Drug Design

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Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors

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Experimental Models of Primitive Cellular Compartments: Encapsulation, Growth, and Division

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The discovery and development of HMG-CoA reductase inhibitors.

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Combinatorial Synthesis of Small Organic Molecules

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Mechanism-Based Target Identification and Drug Discovery in Cancer Research

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Protein-Protein Interactions

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Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs

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Enfuvirtide: the first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes

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A functional genomics approach toward the understanding of secondary metabolism in plant cells

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Naturally-occurring beta-lactamase inhibitors with antibacterial activity

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Application and Limitations of X‐ray Crystallographic Data in Structure‐Based Ligand and Drug Design

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Generating Diverse Skeletons of Small Molecules Combinatorially

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Natural product isolation

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Designing screens: how to make your hits a hit

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Engineering secondary metabolite production in plants

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The Enediyne Antibiotics

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Organic structure analysis

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Mycophenolic Acid: A One Hundred Year Odyssey from Antibiotic to Immunosuppressant

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High-Throughput Method for the Production and Analysis of Large Natural Product Libraries for Drug Discovery

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Drugs, leads, and drug-likeness: an analysis of some recently launched drugs

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The role of natural products in a modern drug discovery program

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NMR screening techniques in drug discovery and drug design

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Target selection in drug discovery

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LC–NMR–MS in drug discovery

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Drug Discovery from Nature

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Diversifying microbial natural products for drug discovery

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Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry

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Cutting the cost of drug development?

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Choosing the Best Pulse Sequences, Acquisition Parameters, Postacquisition Processing Strategies, and Probes for Natural Product Structure Elucidation by NMR Spectroscopy

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Evaluation of the in vitro antioxidant activity of Mangifera indica L. extract (Vimang)

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Pure compound libraries; a new perspective for natural product based drug discovery

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Drug prototypes and their exploitation

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Modern methods to produce natural-product libraries

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Biologically Active Natural Products: Pharmaceuticals

Cutler, S. J., & Cutler, H. G. (2018) · Medical Entomology and Zoology · Cited by 139 · see citing works

Bioactive Compounds from Natural Sources

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A brief history of novel drug discovery technologies

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Aquaculture of three phyla of marine invertebrates to yield bioactive metabolites: process developments and economics

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Saponins in Food, Feedstuffs and Medicinal Plants

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Synthesis of natural-product-based compound libraries

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Structure-based screening of low-affinity compounds

Carr, R. A. E., & Jhoti, H. (2002) · Drug Discovery Today · doi:10.1016/s1359-6446(02)02245-6 · Cited by 110 · see citing works

The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1

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Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia

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High Throughput Screening: The Discovery of Bioactive Substances

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Approaches to identify, clone, and express symbiont bioactive metabolite genes

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Bioactive Compounds from Natural Sources: Isolation, Characterization and Biological Properties

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A Chemical Screening Strategy for the Dereplication and Prioritization of HIV-Inhibitory Aqueous Natural Products Extracts

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Enfuvirtide

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Distinguishing between Natural Products and Synthetic Molecules by Descriptor Shannon Entropy Analysis and Binary QSAR Calculations

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In Quest of Tomorrow’s Medicines

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Finding the needle in the haystack. The dereplication of natural product extracts

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Combinatorial biosynthesis of antimicrobials and other natural products

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The production of hypericins and hyperforin byin vitrocultures of St. John's wort (Hypericum perforatum)

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Toward High-Throughput Synthesis of Complex Natural Product-Like Compounds in the Genomics and Proteomics Age

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Natural products in drug discovery – Creating a new vision

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Drugs: from discovery to approval

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Structure Elucidator: A Versatile Expert System for Molecular Structure Elucidation from 1D and 2D NMR Data and Molecular Fragments

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Drug prototypes and their exploitation

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SENECA: A Platform-Independent, Distributed, and Parallel System for Computer-Assisted Structure Elucidation in Organic Chemistry

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Enzymes in the synthesis of bioactive compounds

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Bioassay Methods in Natural Product Research and Drug Development

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Handbook of Drug Screening

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The Impact of Natural Products on Drug Discovery

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A Method for the Dereplication of Natural Product Extracts using Electrospray HPLC/MS

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LC-NMR: a new tool to expedite the dereplication and identification of natural products

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Natural Products in High Throughput Screening: Automated High-Quality Sample Preparation

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Emerging trends in high-throughput screening

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Screening of Natural Products Extracts for the Presence of Phosphodiesterase Inhibitors Using Liquid Chromatography Coupled Online to Parallel Biochemical Detection and Chemical Characterization

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NMR-based methods and strategies for drug discovery

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Natural Products as Leads for New Pharmaceuticals

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Stereochemistry of Kahalalide F

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Function Oriented Synthesis: The Design, Synthesis, PKC Binding and Translocation Activity of a New Bryostatin Analog

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Natural product-like combinatorial libraries

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The multiple orthogonal tools approach to define molecular causation in the validation of druggable targets

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High Throughput Screening

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Flow NMR applications in combinatorial chemistry

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Validation of Structural Proposals by Substructure Analysis and 13C NMR Chemical Shift Prediction

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Will combinatorial chemistry deliver real medicines?

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A Surface Plasmon Resonance Analysis of the Interaction between the Antibiotic Moenomycin A and Penicillin‐Binding Protein 1b

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Microarray Compound Screening (μARCS) to Identify Inhibitors of HIV Integrase

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Chapter 28. To market, to market — 2000

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APPLICATION OF CENTRIFUGAL PARTITION CHROMATOGRAPHY IN A GENERAL SEPARATION AND DEREPLICATION PROCEDURE FOR PLANT EXTRACTS

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The evolution of microarrayed compound screening

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Chapter 26. To market, to market - 2001

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Chapter 34. To Market, To Market - 1995

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Chapter 33. To market, to market - 2002

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The Elusive Magic Bullet: The Search for the Perfect Drug

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Biodiversity law has had some unintended effects

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The History of Penicillin Production

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Small Molecule — Protein Interactions

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Development of a Plasmepsin II Fluorescence Polarization Assay Suitable for High Throughput Antimalarial Drug Discovery

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Curtain has fallen on hopes of legal bioprospecting

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A Central Natural Product Pool — New Approach in Drug Discovery Strategies

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Automation Strategies in Drug Discovery

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Drugs

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News Analysis

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Marine Natural Products: A Source of Novel Anticancer Drugs

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<i>Candida</i>Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents

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Formulation and Evaluation of Antifungal Soap Using Latex of Calotropis gigantea L.

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