Assay of glioma cell responses to an anticancer drug in a cell-based microfluidic device
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a glioma-related microfluidic device, increasing colchicine concentration or treatment time causes significant changes in rat C6 glioma cell morphology and death rate.
“They observed significant changes in cell morphology and death rate upon increasing colchicine concentration or treatment time.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [198]
Cites
Jemal, A., Siegel, R. L., Ward, E., Hao, Y., Xu, J., Murray, T., & Thun, M. J. (2008) · CA A Cancer Journal for Clinicians · doi:10.3322/ca.2007.0010 · Cited by 10,184 · see citing works
The origins and the future of microfluidics
Whitesides, G. M. (2006) · Nature · doi:10.1038/nature05058 · Cited by 9,687 · see citing works
Stummer, W., Pichlmeier, U., Meinel, T., Wiestler, O. D., Zanella, F., & Reulen, H.-J. (2006) · The Lancet Oncology · doi:10.1016/s1470-2045(06)70665-9 · Cited by 3,423 · see citing works
Fabrication of microfluidic systems in poly(dimethylsiloxane)
McDonald, J. C., Duffy, D. C., Anderson, J. R., Chiu, D. T., Wu, H., Schueller, O. J. A., & Whitesides, G. M. (2000) · Electrophoresis · doi:10.1002/(sici)1522-2683(20000101)21:1 · Cited by 3,338 · see citing works
Microfluidic Large-Scale Integration
Thorsen, T., Maerkl, S. J., & Quake, S. R. (2002) · Science · doi:10.1126/science.1076996 · Cited by 2,223 · see citing works
Genetic Pathways to Glioblastoma
Ohgaki, H., Dessen, P., Jourde, B., Horstmann, S., Nishikawa, T., Patre, P.-L. D., Burkhard, C., Schüler, D., Probst-Hensch, N. M., Maiorka, P. C., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1337 · Cited by 1,268 · see citing works
A microfluidic culture platform for CNS axonal injury, regeneration and transport
Taylor, A. M., Blurton-Jones, M. M., Rhee, S. W., Cribbs, D. H., Cotman, C. W., & Jeon, N. L. (2005) · Nature Methods · doi:10.1038/nmeth777 · Cited by 1,138 · see citing works
Adhesion of cells to surfaces coated with polylysine. Applications to electron microscopy.
Mazia, D., Schatten, G. P., & Sale, W. S. (1975) · The Journal of Cell Biology · doi:10.1083/jcb.66.1.198 · Cited by 876 · see citing works
Epidemiology of primary brain tumors: Current concepts and review of the literature
Wrensch, M., Minn, A. Y., Chew, T., Bondy, M. L., & Berger, M. S. (2002) · Neuro-Oncology · doi:10.1093/neuonc/4.4.278 · Cited by 840 · see citing works
Cellular Response to Hyperosmotic Stresses
Burg, M. B., Ferraris, J. D., & Dmitrieva, N. I. (2007) · Physiological Reviews · doi:10.1152/physrev.00056.2006 · Cited by 793 · see citing works
Biological implications of polydimethylsiloxane-based microfluidic cell culture
Regehr, K. J., Domenech, M., Koepsel, J. T., Carver, K. C., Ellison-Zelski, S. J., Murphy, W. L., Schuler, L. A., Alarid, E. T., & Beebe, D. J. (2009) · Lab on a Chip · doi:10.1039/b903043c · Cited by 719 · see citing works
Versatile, Fully Automated, Microfluidic Cell Culture System
Gómez-Sjöberg, R., Leyrat, A. A., Pirone, D. M., Chen, C. S., & Quake, S. R. (2007) · Analytical Chemistry · doi:10.1021/ac071311w · Cited by 619 · see citing works
Brain and Other Central Nervous System Cancers: Recent Trends in Incidence and Mortality
Legler, J. M., Ries, L. A. G., Smith, M. A., Warren, J. L., Heineman, E. F., Kaplan, R. S., & Linet, M. S. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.16.1382 · Cited by 452 · see citing works
Rat C6 glioma as experimental model system for the study of glioblastoma growth and invasion
Grobben, B., Deyn, P. P. D., & Slegers, H. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0651-7 · Cited by 367 · see citing works
Germ-line p53 mutations predispose to a wide spectrum of early-onset cancers.
Nichols, K. E., Malkin, D. M., Garber, J. E., Fraumeni, J. F., & Li, F. P. (2001) · PubMed · Cited by 356 · see citing works
Recent Advances in the Treatment of Malignant Astrocytoma
Reardon, D. A., Rich, J. N., Friedman, H. S., & Bigner, D. D. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.5302 · Cited by 308 · see citing works
Adult glioma incidence trends in the United States, 1977–2000
Hess, K. R., Broglio, K. R., & Bondy, M. L. (2004) · Cancer · doi:10.1002/cncr.20621 · Cited by 270 · see citing works
Microfluidic self-assembly of tumor spheroids for anticancer drug discovery
Wu, L. Y., Carlo, D. D., & Lee, L. P. (2007) · Biomedical Microdevices · doi:10.1007/s10544-007-9125-8 · Cited by 268 · see citing works
Re: Brain and Other Central Nervous System Cancers: Recent Trends in Incidence and Mortality
Schechter, C. B. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.23.2050 · Cited by 211 · see citing works
Microfluidics: A new cosset for neurobiology
Wang, J., Ren, L. M., Li, L., Liu, W., Zhou, J. H., Yu, W., Tong, D., & Chen, S. (2008) · Lab on a Chip · doi:10.1039/b813495b · Cited by 125 · see citing works
Self-citationWalsh, C. L., Babin, B. M., Kasinskas, R. W., Foster, J. A., McGarry, M. J., & Forbes, N. S. (2008) · Lab on a Chip · doi:10.1039/b810571e · Cited by 121 · see citing works
Ma, B., Zhang, G., Qin, J., & Lin, B. (2008) · Lab on a Chip · doi:10.1039/b809117j · Cited by 100 · see citing works
Colchicine induces apoptosis in organotypic hippocampal slice cultures
Kristensen, B. W., Noer, H., Gramsbergen, J. B., Zimmer, J., & Noraberg, J. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04080-5 · Cited by 80 · see citing works
BARBEE, K. A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1363.006 · Cited by 73 · see citing works
Guchelaar, H., Vermes, I., Koopmans, R. P., Reutelingsperger, C. P. M., & Haanen, C. (1998) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800050788 · Cited by 65 · see citing works
Gene Therapy for Human Malignant Brain Tumors
Rainov, N. G., & Ren, H. (2003) · The Cancer Journal · doi:10.1097/00130404-200305000-00006 · Cited by 61 · see citing works
Komen, J., Wolbers, F., Franke, H. R., Svahn, H. A., Vermes, I., & van den Berg, A. (2008) · Biomedical Microdevices · doi:10.1007/s10544-008-9184-5 · Cited by 50 · see citing works
Characterizing doxorubicin‐induced apoptosis in HepG2 cells using an integrated microfluidic device
Ye, N., Qin, J., Liu, X., Shi, W., & Lin, B. (2007) · Electrophoresis · doi:10.1002/elps.200600450 · Cited by 45 · see citing works
Multi-reservoir device for detecting a soluble cancer biomarker
Daniel, K. D., Kim, G., Vassiliou, C. C., Jalali‐Yazdi, F., Langer, R., & Cima, M. J. (2007) · Lab on a Chip · doi:10.1039/b705143c · Cited by 42 · see citing works
Taming Glioblastoma: Targeting Angiogenesis
Wong, E. T., & Brem, S. S. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.13.1037 · Cited by 41 · see citing works
Viruses for the treatment of malignant glioma.
Gromeier, M., & Wimmer, E. (2001) · PubMed · Cited by 24 · see citing works
Takeda, M., Suzuki, Y., Obara, N., & Nagai, Y. (2000) · Cell and Tissue Research · doi:10.1007/s004410000294 · Cited by 10 · see citing works
Retrospective study of Ukrain treatment in 203 patients with advanced-stage tumors.
Aschhoff, B. (2000) · PubMed · Cited by 7 · see citing works
Rees, J. H. (2008) · Medicine · doi:10.1016/j.mpmed.2008.08.005 · Cited by 1 · see citing works
Flagged first, then by citations
2 of the 36 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Tumor-on-a-chip: from bioinspired design to biomedical application
Liu, X., Fang, J., Huang, S., Wu, X., Xie, X., Wang, J., Liu, F., Zhang, M., Peng, Z., & Hu, N. (2021) · Microsystems & Nanoengineering · doi:10.1038/s41378-021-00277-8 · Cited by 246 · see citing works
Self-citationMicrofluidics for Manipulating Cells
Mu, X., Zheng, W., Sun, J., Zhang, W., & Jiang, X. (2012) · Small · doi:10.1002/smll.201200996 · Cited by 214 · see citing works
Near-Infrared Optical Imaging of Necrotic Cells by Photostable Lanthanide-Based Metallacrowns
Martinić, I., Eliseeva, S. V., Nguyen, T. N., Pecoraro, V. L., & Pètoud, S. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b01587 · Cited by 134 · see citing works
Organ-Tumor-on-a-Chip for Chemosensitivity Assay: A Critical Review
Kashaninejad, N., Nikmaneshi, M., Moghadas, H., Kiyoumarsi Oskouei, A., Rismanian, M., Barisam, M., Saidi, M., & Firoozabadi, B. (2016) · Micromachines · doi:10.3390/mi7080130 · Cited by 79 · see citing works
In vitro biomimetic models for glioblastoma-a promising tool for drug response studies
Stanković, T., Ranđelović, T., Dragoj, M., Burić, S. S., Fernández, L. J., Ochoa, I., Pérez‐García, V. M., & Pešić, M. (2021) · Drug Resistance Updates · doi:10.1016/j.drup.2021.100753 · Cited by 59 · see citing works
Liu, W., Li, L., Wang, J., Tu, Q., Ren, L. M., Wang, Y., & Wang, J. (2012) · Lab on a Chip · doi:10.1039/c2lc00034b · Cited by 50 · see citing works
Self-citationMicrofluidic culture models to study the hydrodynamics of tumor progression and therapeutic response
Buchanan, C. F., & Rylander, M. N. (2013) · Biotechnology and Bioengineering · doi:10.1002/bit.24944 · Cited by 34 · see citing works
Huang, X., Li, L., Tu, Q., Wang, J., Liu, W., Wang, X., Ren, L. M., & Wang, J. (2011) · Microfluidics and Nanofluidics · doi:10.1007/s10404-011-0766-9 · Cited by 33 · see citing works
Self-citationKhanal, G., Hiemstra, S., & Pappas, D. (2014) · The Analyst · doi:10.1039/c3an02324a · Cited by 29 · see citing works
Sun, D., Lü, J., Chen, Z., Yu, Y., & Li, Y. (2014) · Microfluidics and Nanofluidics · doi:10.1007/s10404-014-1373-3 · Cited by 26 · see citing works
Lutter, J. C., Zaleski, C. M., & Pecoraro, V. L. (2018) · Advances in inorganic chemistry · doi:10.1016/bs.adioch.2017.11.007 · Cited by 25 · see citing works
Momoli, C., Costa, B., Lenti, L., Tubertini, M., Parenti, M., Martella, E., Varchi, G., & Ferroni, C. (2025) · Cancers · doi:10.3390/cancers17040700 · Cited by 24 · see citing works
Qing, L., Wang, T., Luo, H.-Y., Du, J.-L., Wang, R.-Y., & Luo, P. (2022) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2022.116832 · Cited by 21 · see citing works
Microphysiological systems for human aging research
Park, S., Laskow, T. C., Chen, J., Guha, P., Dawn, B., & Kim, D. (2024) · Aging Cell · doi:10.1111/acel.14070 · Cited by 20 · see citing works
Diversification of Microfluidic Chip for Applications in Cell-Based Bioanalysis
Liu, W., Li, L., Ren, L. M., Wang, J., Tu, Q., Wang, X., & Wang, J. (2012) · Chinese Journal of Analytical Chemistry · doi:10.1016/s1872-2040(11)60519-7 · Cited by 17 · see citing works
Self-citationColchicine derivative as a potential anti-glioma compound
Fang, K., Liu, J., Li, C.-C., Cheng, C.-C., Hsieh, Y.-T., Chai, K. M., Lien, Y.-A., & Tzeng, S. (2015) · Journal of Neuro-Oncology · doi:10.1007/s11060-015-1874-2 · Cited by 16 · see citing works
A membrane-based microfluidic device for mechano-chemical cell manipulation
Ravetto, A. A., Hoefer, I. E., den Toonder, J. M. J., & Bouten, C. V. C. (2016) · Biomedical Microdevices · doi:10.1007/s10544-016-0040-8 · Cited by 13 · see citing works
Noorani, B., Cucullo, L., Ahn, Y., Kadry, H., Bhalerao, A., Raut, S., Nozohouri, E., & Chowdhury, E. A. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220706112711 · Cited by 8 · see citing works
Cytotoxic and apoptotic functions of licofelone on rat glioma cells
Kuş, G., Öztopçu-Vatan, P., Uyar, R., & Kabadere, S. (2013) · Acta Biologica Hungarica · doi:10.1556/abiol.64.2013.4.4 · Cited by 7 · see citing works
Tumor organoids on-a-chip and the role of AI in predictive oncology and personalized cancer medicine
Mirlohi, M. S., Hamdi, E., Karimi, M. H., Salami, S., Aref, A. R., Kohan, H. G., Ghayoor, A., Seyfoori, A., & Akbari, M. (2026) · Biofabrication · doi:10.1088/1758-5090/ae3644 · Cited by 6 · see citing works
Microfluidics: Organ-on-a-chip
Aghamiri, S., Rabiee, N., Ahmadi, S., Rabiee, M., Bagherzadeh, M., & Karimi, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818791-3.00001-2 · Cited by 6 · see citing works
Advancements in Microfluidic Platforms for Glioblastoma Research
Raman, R., Prabhu, V., Kumar, P., & Mani, N. K. (2024) · Chemistry · doi:10.3390/chemistry6050060 · Cited by 3 · see citing works
Microfluidics-Based Cell Manipulation and Analysis
Wang, J., Liu, W., Li, L., Tu, Q., Wang, J., Ren, L. M., Wang, X., & Liu, A. (2011) · InTech eBooks · doi:10.5772/22215 · Cited by 1 · see citing works
Self-citationIn silico Search for Tubulin Polymerization Inhibitors
Sahakyan, H., Arakelov, G., & Nazaryan, K. (2018) · Molecular Biology · doi:10.1134/s0026893318040179 · Cited by 1 · see citing works
Microfluidic devices for mechanical characterization and manipulation of monocytes
Ravetto, A. A. (2015) · TU/e Research Portal · doi:10.6100/ir789319
Human organs-on-a-chip for cancer modeling
Hegde, M., Girisa, S., & Harsha, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13782-2.00005-x
Bioinformatics approaches for the validation of functional analysis of 3D cancer models
Padhy, I., Saha, A., & Sharma, T. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-26518-1.00004-5
Tumor-on-a-Chip: From Biomimetic Tumor-Immune Microenvironments to Therapeutic Insights
Çetin, Y. (2025) · Biochemistry · doi:10.5772/intechopen.1012047
Time-dependent cytokine landscapes in an ex vivo microfluidic glioblastoma platform
Moursi, A., Barry, A., Feugere, L., Iles, A., Scott, I., Achawal, S., Rajaraman, C., Beltrán-Álvarez, P., & Greenman, J. (2026) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-026-04486-w
- Authors
- Liu, W., Sun, P., Yang, L., Wang, J., Li, L., & Wang, J.
- Affiliations
- Northwest A&F University (CN)
- Corresponding author
- Wang, Jinfeng
- Wang, Jinyi
- Venue
- Microfluidics and Nanofluidics
- Published
- 2010-03-20
- Volume
- 9
- Issue
- 4-5
- Pages
- 717-725
- ISSN
- 1613-4982 (ISSN-L)
- 1613-4990
- OpenAlex
- W1984743998
- Cited by
- 29
- References
- 36
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Microfluidics and Nanofluidics (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- glioma, C6 glioma cells, microfluidics, colchicine, anticancer drug cytotoxicity, cell viability, cell morphology, in vitro model, glioma detection
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
