Behavioral changes following uptake of HIV pre-exposure prophylaxis among men who have sex with men in a clinical setting.
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We describe changes in sexual behaviors among men who have sex with men (MSM) following initiation of pre-exposure prophylaxis (PrEP) in a clinic-based sample of MSM initiating PrEP in Providence, Rhode Island. Data were collected at baseline, 3, and 6 months following PrEP initiation including total number of anal sex partners and condom use. A longitudinal mixed effects model assessed changes in number of partners and condom use over time, adjusting for age, race, and education. There was no statistically significant difference in total number of partners over time. There was a significant increase in number of condomless anal sex partners at the 6-month visit compared to baseline (mean change +1.31 partners, 95% confidence interval 0.09-2.53, P = 0.035). As condomless anal sex may increase following PrEP uptake, adherence counseling and efforts to retain patients in PrEP care, especially during periods of non-condom use, are important as PrEP is more widely implemented.
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MSM taking PrEP might compensate for decreased HIV acquisition risk by using condoms less frequently or modifying their behavior in other ways, although data regarding this behavior are inconsistent.
“MSM taking PrEP might compensate for decreased HIV acquisition risk by using condoms less frequently or modifying their behavior in other ways (202,203), although data regarding this behavior are inconsistent.”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [202]
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Salazar, R., Emetu, R. E., & Missari, S. (2026) · Health Promotion Practice · doi:10.1177/15248399261491326
- Authors
- Oldenburg, C. E., Nunn, A. S., Montgomery, M., Almonte, A., Mena, L., Patel, R. R., Mayer, K. H., & Chan, P. A.
- Affiliations
- University of California, San Francisco (US)
- Brown University (US)
- University of Mississippi (US)
- Washington University in St. Louis (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Chan, Philip A.
- ORCID
- Venue
- AIDS and Behavior
- Published
- 2017-02-01
- Volume
- 22
- Issue
- 4
- Pages
- 1075-1079
- ISSN
- 1090-7165 (ISSN-L)
- 1573-3254
- PMC
- PMC5538946
- OpenAlex
- W2584287500
- Cited by
- 76
- References
- 14
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 7 · 2023: 3 · 2022: 10 · 2021: 7 · 2020: 7 · 2019: 15 · 2018: 13 · 2017: 3
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- AIDS and Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (1K23AI096923, P30AI042853)
- National Institute on Drug Abuse (T32DA013911)
- National Institute of Mental Health (R25MH083620)
- National Center for Advancing Translational Sciences (KL2TR000450)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Keywords
- HIV pre-exposure prophylaxis, men who have sex with men, sexual behavior, condom use, condomless anal sex, number of sexual partners, HIV prevention
- MeSH terms
- Adult, Humans, Male, Rhode Island, Sexual Behavior, Sexual Partners, HIV Infections, Outcome Assessment, Health Care, Homosexuality, Male, Anti-HIV Agents, Safe Sex, Young Adult, Pre-Exposure Prophylaxis
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