Latent class analysis of syndemic factors associated with sustained viral suppression among ryan white HIV/AIDS program clients in Miami, 2017
Open accessAbstract
The study's objective was to identify the association between sustained viral suppression (all viral load tests < 200 copies/ml per year) and patterns of co-occurring risk factors including, mental health, substance use, sexual risk behavior, and adverse social conditions for people with HIV (PWH). Latent class analysis followed by multivariable logistic regression was conducted for 6554 PWH in the Miami-Dade County Ryan White Program during 2017, and a five-class model was selected. Compared to Class 1 (no risk factors), the odds of achieving sustained viral suppression was significantly lower for Class 2 (mental health) (aOR: 0.67; 95% CI 0.54-0.83), Class 3 (substance use and multiple sexual partners) (0.60; 0.47-0.76), Class 4 (substance use, multiple sexual partners, and domestic violence) (0.71; 0.55-0.93), and Class 5 (mental health, substance use, multiple sexual partners, domestic violence, and homelessness) (0.26; 0.19-0.35). Findings indicate the need for targeted interventions that address these syndemic factors.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
None of the 24 studies using LCA to identify classes of syndemic determinants tested the nature of the interaction between these factors to determine synergy as opposed to comorbidity.
“None of the 24 studies using LCA to identify classes of syndemic determinants tested the nature of the interaction between these factors to determine synergy as opposed to comorbidity.”
From Recommendations for empirical syndemics analyses: A stepwise methodological guide (2024) · cites this paper as [49]
The Methods (Statistical analysis; page unavailable) describe this paper’s LCA and regression analyses, but no test of whether the factors interact synergistically rather than merely co-occur. This supports the claim for this study alone; the paper does not assess 24 studies or establish that none of them tested synergy. (LLM, conf=0.82)
Experimental — accuracy not yet measuredOf the 24 publications listed on PubMed that use LCA to explore syndemic relationships, the items in a class are either all diseases or health conditions, all social determinants, or a combination of both.
“Of the 24 publications listed on PubMed that use LCA to explore syndemic relationships, the items in a class are either all diseases or health conditions, all social determinants, or a combination of both [40,[48], [49], [50], [51], [52], [53], [54]].”
From Recommendations for empirical syndemics analyses: A stepwise methodological guide (2024) · cites this paper as [49]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Estimating the Dimension of a Model
Schwarz, G. (1978) · The Annals of Statistics · doi:10.1214/aos/1176344136 · Cited by 47,033 · see citing works
Syndemics and public health: Reconceptualizing disease in bio-social context
Singer, M., & Clair, S. (2003) · Medical Anthropology Quarterly · doi:10.1525/maq.2003.17.4.423 · Cited by 1,140 · see citing works
Depression and HIV/AIDS Treatment Nonadherence: A Review and Meta-analysis
Gonzalez, J. S., Batchelder, A., Psaros, C., & Safren, S. (2011) · Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31822d490a · Cited by 782 · see citing works
Mental health and HIV/AIDS: the need for an integrated response
Remien, R. H., Stirratt, M. J., Nguyen, N., Robbins, R. N., Pala, A. N., & Mellins, C. A. (2019) · AIDS · doi:10.1097/qad.0000000000002227 · Cited by 727 · see citing works
Shubber, Z., Mills, E. J., Nachega, J. B., Vreeman, R., de Freitas, M. A., Bock, P., Nsanzimana, S., Penazzato, M., Appolo, T., Doherty, M. C., et al. (2016) · PLoS Medicine · doi:10.1371/journal.pmed.1002183 · Cited by 528 · see citing works
Alcohol Use and Antiretroviral Adherence: Review and Meta-Analysis
Hendershot, C. S., Stoner, S. A., Pantalone, D. W., & Simoni, J. M. (2009) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181b18b6e · Cited by 485 · see citing works
Singer, M. C., Erickson, P. I., Badiane, L., Diaz, R., Ortiz, D., Abraham, T., & Nicolaysen, A. M. (2006) · Social Science & Medicine · doi:10.1016/j.socscimed.2006.05.012 · Cited by 371 · see citing works
Vital Signs: HIV Transmission Along the Continuum of Care — United States, 2016
Li, Z., Purcell, D. W., Sansom, S. L., Hayes, D., & Hall, H. I. (2019) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6811e1 · Cited by 268 · see citing works
Prevalence and Predictors of Substance Use Disorders Among HIV Care Enrollees in the United States
Hartzler, B. J., Dombrowski, J. C., Crane, H. M., Eron, J. J., Geng, E. H., Mathews, W. C., Mayer, K. H., Moore, R. D., Mugavero, M. J., Napravnik, S., et al. (2016) · AIDS and Behavior · doi:10.1007/s10461-016-1584-6 · Cited by 218 · see citing works
Harris, N., Johnson, A. S., Huang, Y.-L. A., et al. (2019) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6848e1 · Cited by 181 · see citing works
Sullivan, K. A., Messer, L. C., & Quinlivan, E. B. (2015) · AIDS Patient Care and STDs · doi:10.1089/apc.2014.0278 · Cited by 174 · see citing works
The Impact of Mental Health and Substance Abuse Factors on HIV Prevention and Treatment
Walkup, J., Blank, M. B., Gonzalez, J. S., Safren, S., Schwartz, R., Brown, L., Wilson, I., Knowlton, A., Lombard, F., Grossman, C., et al. (2008) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181605b26 · Cited by 150 · see citing works
Crepaz, N., Dong, X., Wang, X., et al. (2018) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6704a2 · Cited by 145 · see citing works
Beer, L., Mattson, C. L., Bradley, H. M., & Skarbinski, J. (2016) · Medicine · doi:10.1097/md.0000000000003171 · Cited by 141 · see citing works
Wilson, P. A., Nanin, J., Amesty, S., Wallace, S., Cherenack, E. M., & Fullilove, R. (2014) · Journal of Urban Health · doi:10.1007/s11524-014-9895-2 · Cited by 133 · see citing works
Crepaz, N., Tang, T., Marks, G. N., Mugavero, M. J., Espinoza, L., & Hall, H. I. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw418 · Cited by 129 · see citing works
Does Race Matter in Addressing Homelessness? A Review of the Literature
Jones, M. M. (2016) · World Medical & Health Policy · doi:10.1002/wmh3.189 · Cited by 113 · see citing works
Virological rebound after suppression on highly active antiretroviral therapy
Mocroft, A., Ruiz, L., REISS, P. C., et al. (2003) · AIDS · doi:10.1097/00002030-200308150-00003 · Cited by 106 · see citing works
Meyer, J. P., Althoff, A., & Altice, F. L. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit427 · Cited by 105 · see citing works
Disparities in Engagement in Care and Viral Suppression Among Persons With HIV
Muthulingam, D., Chin, J., Hsu, L. C., Scheer, S., & Schwarcz, S. K. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3182894555 · Cited by 96 · see citing works
Mizuno, Y., Purcell, D. W., Knowlton, A. R., Wilkinson, J. D., Gourevitch, M. N., & Knight, K. R. (2014) · AIDS and Behavior · doi:10.1007/s10461-014-0890-0 · Cited by 76 · see citing works
Predicting Virologic Failure in an HIV Clinic
Robbins, G. K., Johnson, K. L., Chang, Y., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/650537 · Cited by 75 · see citing works
Sheehan, D. M., Fennie, K., Mauck, D. E., et al. (2017) · AIDS Patient Care and STDs · doi:10.1089/apc.2016.0197 · Cited by 75 · see citing works
Self-citationMandsager, P., Marier, A. F., Cohen, S. M., et al. (2018) · American Journal of Public Health · doi:10.2105/ajph.2018.304689 · Cited by 69 · see citing works
Krumme, A. A., Kaigamba, F., Binagwaho, A., Murray, M. B., Rich, M., & Franke, M. F. (2014) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2014-204494 · Cited by 64 · see citing works
Bradley, H. M., Mattson, C. L., Beer, L., Huang, P. C., & Shouse, R. L. (2016) · AIDS · doi:10.1097/qad.0000000000001164 · Cited by 57 · see citing works
Chan, P. A., Rose, J. S., Maher, J. A., Benben, S., Pfeiffer, K., Almonte, A. A., Poceta, J., Oldenburg, C. E., Parker, S., Marshall, B. D. L., et al. (2015) · AIDS Patient Care and STDs · doi:10.1089/apc.2015.0113 · Cited by 53 · see citing works
Homelessness, HIV, and Incomplete Viral Suppression
Thakarar, K., Morgan, J. R., Gaeta, J. M., Hohl, C., & Drainoni, M. (2016) · Journal of Health Care for the Poor and Underserved · doi:10.1353/hpu.2016.0020 · Cited by 45 · see citing works
Robinson, A. C., Knowlton, A. R., Gielen, A. C., & Gallo, J. J. (2016) · Journal of Behavioral Medicine · doi:10.1007/s10865-015-9670-1 · Cited by 44 · see citing works
Benzie, A. A., Bansi, L. K., Sabin, C. A., et al. (2007) · AIDS · doi:10.1097/qad.0b013e3281532ca7 · Cited by 38 · see citing works
Cleland, C. M., Lanza, S. T., Vasilenko, S. A., & Gwadz, M. V. (2017) · Frontiers in Public Health · doi:10.3389/fpubh.2017.00237 · Cited by 27 · see citing works
Remien, R. H., Dolezal, C. L., Wagner, G. J., et al. (2013) · AIDS and Behavior · doi:10.1007/s10461-013-0656-0 · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Recommendations for empirical syndemics analyses: A stepwise methodological guide
Bulled, N. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38931 · Cited by 6 · see citing works
- Authors
- Dawit, R., Trepka, M. J., Gbadamosi, S. O., Fernandez, S. B., Caleb-Adepoju, S. O., Brock, P., Ladner, R. A., & Sheehan, D. M.
- Affiliations
- Florida International University (US)
- Corresponding author
- Sheehan, Diana M.
- ORCID
- Venue
- AIDS and Behavior
- Published
- 2021-01-20
- Volume
- 25
- Issue
- 7
- Pages
- 2252-2258
- ISSN
- 1090-7165 (ISSN-L)
- 1573-3254
- PMC
- PMC8169572
- OpenAlex
- W3124916313
- Cited by
- 8
- References
- 32
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 1
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- AIDS and Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Minority Health and Health Disparities (R01MD013563 and R01MD012421, U54MD012393, K01MD013770, F31MD015234, R01MD013563-02S1)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Health Sciences › Health Professions › General Health Professions › Homelessness and Social Issues
- Keywords
- HIV, syndemic, people living with HIV, mental health, substance use, sexual risk behavior, multiple sexual partners, domestic violence, homelessness, Ryan White HIV/AIDS Program, Miami-Dade County
- MeSH terms
- Sustained Virologic Response, Syndemic, Latent Class Analysis, Florida, Humans, HIV Infections, Substance-Related Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
