Psychological and interpersonal factors associated with sexualized drug use among men who have sex with men: a mixed-methods systematic review
Abstract
Chemsex-the use of specific drugs during planned sexual activity to sustain or enhance sexual functioning (Bourne et al., 2015)-is widely reported as a major public health issue among gay, bisexual, and other men who have sex with men (GBM) in Western countries. Considering current evidence surrounding Chemsex, we conducted a mixed-methods systematic review regarding psychological and interpersonal factors associated with Chemsex behaviors among GBM. Publications covering Chemsex and psychological or social variables were eligible. Theoretical papers and studies solely presenting physical health outcomes were excluded. 35 English papers published between January 2008 and June 2019 were identified through PubMed, Scopus, and PsycINFO. We performed a parallel-results convergent synthesis (Hong, Pluye, Bujold, & Wassef, 2017) on results extracted from qualitative and quantitative studies comprising the final corpus. Qualitative data suggest that six mechanisms promote Chemsex-related behaviors: dealing with painful emotions or stressful events; normalization and risk minimization of sexualized drug use; giving into interpersonal pressure or fulfilling desire for community belonging; increasing intimacy or connectedness; enhancing sexual performance and functioning; lessening interpersonal and sexual inhibitions. In quantitative reports, six variable categories emerged: sexual control and self-efficacy; sexual functioning; mental health; attitudes toward substance use; life stressors and internalized stressors; and identification with sexual identities or scenes. This review summarizes key psychological and interpersonal correlates of Chemsex among GBM. Further research is needed to replicate current findings and explore new hypotheses across multiple GBM sociodemographic groups and cultural contexts, following best practices in sampling for hard-to-reach populations.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Use of drugs such as methamphetamine, gamma-hydroxybutyric acid, gamma-butyrolactone, and alkyl nitrites ("poppers") to facilitate sexual activity or enhance pleasure (chemsex) may lead to uncontrolled and risky sexual behavior due to their disinhibitory actions on brain dopamine turnover.
“Clinicians should be aware that the use of drugs such as methamphetamine, gamma-hydroxybutyric acid, gamma-butyrolactone, and alkyl nitrites (“poppers”) to facilitate engagement in sexual activity or to enhance pleasure from it, described as “chemsex,” may also lead to uncontrolled and risky sexual behavior124 given their common disinhibitory actions on brain dopamine turnover.125”
From Assessment and treatment of compulsive sexual behavior disorder: a sexual medicine perspective (2024) · cites this paper as [124]
Cites
A typology of reviews: an analysis of 14 review types and associated methodologies
Grant, M. J., & Booth, A. (2009) · Health Information & Libraries Journal · doi:10.1111/j.1471-1842.2009.00848.x · Cited by 10,817 · see citing works
Methods for the thematic synthesis of qualitative research in systematic reviews
Thomas, J., & Harden, A. (2008) · BMC Medical Research Methodology · doi:10.1186/1471-2288-8-45 · Cited by 9,312 · see citing works
Reprint—Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & and the PRISMA Group (2009) · Physical Therapy · doi:10.1093/ptj/89.9.873 · Cited by 2,486 · see citing works
Hong, Q. N., Pluye, P., Bujold, M., & Wassef, M. (2017) · Systematic Reviews · doi:10.1186/s13643-017-0454-2 · Cited by 754 · see citing works
Noyes, J., Booth, A., Moore, G., Flemming, K., Tunçalp, Ö., & Shakibazadeh, E. (2019) · BMJ Global Health · doi:10.1136/bmjgh-2018-000893 · Cited by 497 · see citing works
Sexual Compulsivity and Sexual Risk in Gay and Bisexual Men
Grov, C., Parsons, J. T., & Bimbi, D. S. (2010) · Archives of Sexual Behavior · doi:10.1007/s10508-009-9483-9 · Cited by 185 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Assessment and treatment of compulsive sexual behavior disorder: a sexual medicine perspective
Briken, P., Bőthe, B., Carvalho, J., Coleman, E., Giraldi, A., Kraus, S. W., Lew-Starowicz, M., & Pfaus, J. G. (2024) · Sexual Medicine Reviews · doi:10.1093/sxmrev/qeae014 · Cited by 55 · see citing works
- Authors
- Lafortune, D., Blais, M., Miller, G., Dion, L., Lalonde, F., & Dargis, L.
- Affiliations
- Université du Québec à Montréal (CA)
- Corresponding author
- Lafortune, David
- Venue
- Archives of Sexual Behavior
- Published
- 2020-10-27
- Volume
- 50
- Issue
- 2
- Pages
- 427-460
- ISSN
- 0004-0002 (ISSN-L)
- 1573-2800
- OpenAlex
- W3096115473
- Cited by
- 105
- References
- 6
- Citations by year
- 2026: 20 · 2025: 13 · 2024: 24 · 2023: 30 · 2022: 13 · 2021: 5
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Sexual Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Faculty of Social Sciences of the Université du Québec à Montréal
- Topics
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Social Psychology › LGBTQ Health, Identity, and Policy
- Keywords
- chemsex, men who have sex with men, gay and bisexual men, psychological factors, interpersonal factors, sexual self-efficacy, sexual function, mental health, attitudes toward substance use, life events, sexual identity, community belonging, sexual performance, intimacy
- MeSH terms
- Sexual and Gender Minorities, Health Risk Behaviors, Humans, Interpersonal Relations, Male, Sexual Behavior, Sexual Partners, Homosexuality, Male, Substance-Related Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review