Effect of Rhaponticum carthamoides Extract on Structural and Metabolic Parameters of Erythrocytes in Rats with Cerebral Ischemia
Abstract
Cerebral ischemia in rats was accompanied by an increase in erythrocyte degradation, which results from changes in lipid composition of their membranes. The content of lipids and phospholipid fraction (phosphatidylcholine, sphingomyelin, and phosphatidylserine) decreased, while the relative content of lysophospholipids increased in erythrocyte membranes. The course of treatment with Rhaponticum carthamoides extract (150 mg/kg perorally, 5 days) contributed to an increase in the contents of total lipids and phospholipids (primarily of sphingomyelin and phosphatidylserine) and decrease in the ratio of lysophospholipids in the erythrocyte membrane of rats with cerebral ischemia. Morphological characteristics of erythrocytes returned to normal, which manifested in an increase in the number of discocytes and decrease in the count of degenerated cells.
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There are no observable indications or symptoms of toxicity for Rhaponticum carthamoides, indicating a wide margin of safety.
“There are no observable indications or symptoms of toxicity, indicating a wide margin of safety [44,133,134,135,136,137,138,139,140,141,142].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [140]
In vivo investigations of Rhaponticum carthamoides include cognitive function effects, metabolic regulation, stress management, and cytotoxicity.
“These investigations include a wide range of activities, such as cognitive function effects, metabolic regulation, stress management, and cytotoxicity [44,133,134,135,136,137,138,139,140,141,142].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [140]
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A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189 · see citing works
The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes
Dodge, J. T., Mitchell, C. D., & Hanahan, D. J. (1963) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(63)90042-0 · Cited by 4,419 · see citing works
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Plant Adaptogens—History and Future Perspectives
Todorova, V., Ivanov, K., Delattre, C., Nalbantova, V., Karcheva-Bahchevanska, D., & Ivanova, S. (2021) · Nutrients · doi:10.3390/nu13082861 · Cited by 121 · see citing works
Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition
Todorova, V., Ivanova, S., Chakarov, D., Kraev, K., & Ivanov, K. (2024) · Nutrients · doi:10.3390/nu16091382 · Cited by 31 · see citing works
“[140] The impact of different levels of R. carthamoides hay meal in rat diets.”
Background
- Authors
- Plotnikov, M. B., Aliev, O. I., Vasil’ev, A. S., Andreeva, V. Y., Krasnov, E. A., & Kalinkina, G. I.
- Affiliations
- Siberian State Medical University (RU)
- ORCID
- Andreeva, V. Yu.
- Venue
- Bulletin of Experimental Biology and Medicine
- Published
- 2008-07
- Volume
- 146
- Issue
- 1
- Pages
- 45-48
- ISSN
- 0007-4888 (ISSN-L)
- 1573-8221
- OpenAlex
- W2064434743
- Cited by
- 10
- References
- 2
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2021: 1 · 2020: 1 · 2015: 1 · 2014: 1
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Bulletin of Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
- Keywords
- Rhaponticum carthamoides, cerebral ischemia, erythrocytes, erythrocyte membrane lipids, phospholipids, sphingomyelin, phosphatidylserine, lysophospholipids, erythrocyte morphology, discocytes, plant extracts, neuroprotection
- MeSH terms
- Animals, Brain Ischemia, Erythrocytes, Male, Phospholipids, Plant Extracts, Rats, Wistar, Leuzea, Rats
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