Vascular Endothelial Growth Factor and its Receptors in the Placenta of Pregnant Women with Obesity
Abstract
Comparative morphological study of placentas from women with obesity and normal body weight was performed. Expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR-1, VEGFR-2, VEGFR-3) was detected by immunohistochemical methods. Nonbranching angiogenesis predominated in the placentas from obese women. Immunohistochemical analysis showed reduced intensity of the reaction to VEGF in the syncytiotrophoblast and vascular endothelium of stem villi and enhanced VEGF expression in non-villous cytotrophoblast and endothelial cells of capillaries of mature intermediate and terminal villi; reduced expression of VEGFR-1 and increased levels of VEGFR-2 and VEGFR-3 in the studied structures were also noted.
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There is some evidence of changes in angiogenesis in the placenta of obese women.
“There is also some evidence of changes in angiogenesis in the placenta of obese women (157).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [157]
Cites
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CHILDHOOD OBESITY, HYPERTENSION, THE METABOLIC SYNDROME AND ADULT CARDIOVASCULAR DISEASE
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Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
- Authors
- Dubova, E. A., Pavlov, K. A., Borovkova, E. I., Bayramova, M. A., Makarov, I. O., & Shchegolev, A. I.
- Affiliations
- Sechenov University (RU)
- ORCID
- Borovkova, E. I.
- Venue
- Bulletin of Experimental Biology and Medicine
- Published
- 2011-06
- Volume
- 151
- Issue
- 2
- Pages
- 253-258
- ISSN
- 0007-4888 (ISSN-L)
- 1573-8221
- OpenAlex
- W2001500221
- Cited by
- 37
- References
- 11
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 6 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Bulletin of Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- vascular endothelial growth factor, VEGF receptors, VEGFR1, VEGFR2, VEGFR-3, placenta, maternal obesity, placental angiogenesis, syncytiotrophoblast, cytotrophoblast, placental villi, capillary endothelium
- MeSH terms
- Adult, Chorionic Villi, Endothelium, Vascular, Female, Humans, Obesity, Placenta, Pregnancy, Trophoblasts, Gene Expression, Case-Control Studies, Receptors, Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor A
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