Effect of Acute Emotional Stress on Proteomic Profile of Selected Brain Areas and Lysosomal Proteolysis in Rats with Different Behavioral Activity
Abstract
We compared proteome profiles of selected brain areas (cortex, amygdala, hippocampus, and reticular formation) and measured cathepsins B and D activity in liver lysosomal fraction in rats with different behavioral activity under conditions of emotional stress. In passive rats, the expression of some proteins in various brain regions was changed and baseline cathepsin B activity was higher than in active animals. Taken together, the results attest to differences in the adaptive response formation in rats, depending on behavioral features.
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The preliminary division of animals according to their behavior increases the repeatability of obtained results [43,44].
“The preliminary division of animals according to their behavior increases the repeatability of obtained results [43,44].”
From Anxiolytic and Antioxidant Effect of Phytoecdysteroids and Polyphenols from Chenopodium quinoa on an In Vivo Restraint Stress Model (2022) · cites this paper as [43]
Individual behavioral differences play an important role in the adaptation of animals to stress.
“An important role in the adaptation of animals to stress is played by individual behavioral differences, which have been confirmed by the results of previous studies [39,40].”
From Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of Spinacia oleracea L. (2021) · cites this paper as [39]
Preliminary separation of animals into groups similar in behavior increases the verifiability of the obtained results.
“Preliminary separation of animals into groups similar in behavior increases the verifiability of the obtained results [39,40].”
From Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of Spinacia oleracea L. (2021) · cites this paper as [39]
Rats with different behaviors demonstrate different adaptive responses to stress.
“Rats with different behaviors demonstrate different adaptive responses to stress.”
From Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of Spinacia oleracea L. (2021) · cites this paper as [39]
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Self-citationEffect of Coenzyme Q10 on Proteomic Profile of Rat Plasma under Conditions of Metabolic Stress
Шаранова, Н. Э., Baturina, V. A., Васильев, А. В., & Gapparov, M. M. G. (2011) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-011-1414-9 · Cited by 9 · see citing works
Proteomic Study of Rat Hippocampus Under Conditions of Emotional Stress
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Self-citationBiochemical Features in Rats with Different Behavioral Activity under Conditions of Emotional Stress
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Sidorova, Y. S., Shipelin, V. A., Petrov, N. A., Zorin, S. N., & Mazo, V. K. (2022) · Molecules · doi:10.3390/molecules27249003 · Cited by 11 · see citing works
Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of Spinacia oleracea L.
Sidorova, Y. S., Shipelin, V. A., Petrov, N. A., Zorin, S. N., & Mazo, V. K. (2021) · Plants · doi:10.3390/plants10122555 · Cited by 11 · see citing works
- Authors
- Sharanova, N. E., Kirbaeva, N. V., Toropygin, I. Y., Khryapova, E. V., Koplik, E. V., Soto, C. K., Pertsov, S. S., & Vasiliev, A. V.
- Affiliations
- Federal Research Centre of Nutrition and Biotechnology (RU)
- Institute of Biomedical Chemistry (RU)
- Institute of Normal Physiology named after P.K. Anokhin (RU)
- Venue
- Bulletin of Experimental Biology and Medicine
- Published
- 2016-07
- Volume
- 161
- Issue
- 3
- Pages
- 355-358
- ISSN
- 0007-4888 (ISSN-L)
- 1573-8221
- OpenAlex
- W2514707081
- Cited by
- 6
- References
- 9
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2019: 2
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bulletin of Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- acute emotional stress, brain proteome, lysosomal proteolysis, cathepsin B, cathepsin D, behavioral activity, amygdala, hippocampus, cerebral cortex, reticular formation, adaptive response, liver lysosomes
- MeSH terms
- Animals, Brain, Cathepsin B, Cathepsin D, Hippocampus, Lysosomes, Male, Stress, Psychological, Rats, Wistar, Proteomics, Rats, Proteolysis
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