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Cited by 487Gut microbiota and healthParkinson's Disease Mechanisms and TreatmentsGastrointestinal motility and disorders

Analysis of Gut Microbiota in Patients with Parkinson’s Disease

Open access
Petrov, V. A., Saltykova, I. V., Zhukova, I. A., Alifirova, V. M., Zhukova, N. G., Dorofeeva, Yu. B., Tyakht, A. V., Kovarsky, B. A. +11 more·2017·Bulletin of Experimental Biology and Medicine
DOI 10.1007/s10517-017-3700-7
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Abstract

Gut microbiota of patients with Parkinson's disease and healthy volunteers was analyzed by the method of high throughput 16S rRNA sequencing of bacterial genomes. In patients with Parkinson's diseases, changes in the content of 9 genera and 15 species of microorganisms were revealed: reduced content of Dorea, Bacteroides, Prevotella, Faecalibacterium, Bacteroides massiliensis, Stoquefichus massiliensis, Bacteroides coprocola, Blautia glucerasea, Dorea longicatena, Bacteroides dorei, Bacteroides plebeus, Prevotella copri, Coprococcus eutactus, and Ruminococcus callidus, and increased content of Christensenella, Catabacter, Lactobacillus, Oscillospira, Bifidobacterium, Christensenella minuta, Catabacter hongkongensis, Lactobacillus mucosae, Ruminococcus bromii, and Papillibacter cinnamivorans. This microbiological pattern of gut microflora can trigger local inflammation followed by aggregation of α-synuclein and generation of Lewy bodies.

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References 14 · Cited by 487

Research works printed but not linked: 56

  1. Barry G., Mattick J. S. The role of regulatory RNA in cognitive evolution //Trends in cognitive sciences. -2012. -Т. 16. -№. 10. -С. 497-503. doi: 10.1016/j.tics.2012.08.007. · DOI
  2. Berstad K., Berstad J. E. R. Parkinson's disease; the hibernating spore hypothesis //Medical hypotheses. -2017. -Т. 104. -С. 48-53. doi: 10.1016/j.mehy.2017.05.022. · DOI
  3. Bhattarai Y. et al. Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT3 receptor expression via acetate production //American Journal of Physiology-Gastrointestinal and Liver Physiology. -2017. -Т. 313. -№.
  4. Bien-Ly N., Watts R. J. The Blood-Brain Barrier's Gut Check //Science translational medicine. -2014. -Т. 6. -№. 263. -С. 263fs46-263fs46. doi: 10.1126/scitranslmed.aaa2543 · DOI
  5. Borg I., Groenen P. J. F. Modern multidimensional scaling: Theory and applications. -Springer Science & Business Media, 2005. ISBN 0-387-94845-7
  6. Braniste V. et al. The gut microbiota influences blood-brain barrier permeability in mice //Science translational medicine. -2014. -Т. 6. -№. 263. -С. 263ra158- 263ra158. doi:10.1126/scitranslmed.3009759. · DOI · Paper page
  7. Brooks G. et al. Jawetz Melnick&Adelbergs Medical Microbiology 26/E. - McGraw Hill Professional, 2012. ISBN 71815783
  8. Brüssow H. Turning the inside out: the microbiology of atopic dermatitis //Environmental microbiology. -2016. -Т. 18. -№. 7. -С. 2089-2102. doi: 10.1111/1462-2920.13050. · DOI
  9. Chao A. Nonparametric estimation of the number of classes in a population //Scandinavian Journal of statistics. -1984. -С. 265-270.
  10. Charlson E. S. et al. Topographical continuity of bacterial populations in the healthy human respiratory tract //American journal of respiratory and critical care medicine. - 2011. -Т. 184. -№. 8. -С. 957-963. doi: 10.1164/rccm.201104-0655OC · DOI · Paper page
  11. Cox P. A., Kostrzewa R. M., Guillemin G. J. BMAA and neurodegenerative illness //Neurotoxicity research. -2018. -Т. 33. -№. 1. -С. 178-183. doi: 10.1007/s12640- 017-9753-6 · DOI
  12. Craven M. et al. Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohn's disease //PLoS One. -2012. -Т. 7. -№. 7. -С. E41594. doi: 10.1007/s12640-017-9753-6 · DOI
  13. Deng H., Wang P., Jankovic J. The genetics of Parkinson disease //Ageing research reviews. -2018. -Т. 42. -С. 72-85. doi: 10.1016/j.arr.2017.12.007 · DOI · Paper page
  14. Dewhirst F. E. et al. The human oral microbiome //Journal of bacteriology. -2010.
  15. Dreno B. et al. Skin microbiome and acne vulgaris: Staphylococcus, a new actor in acne //Experimental dermatology. -2017. -Т. 26. -№. 9. -С. 798-803. doi: 10.1111/exd.13296 · DOI
  16. Fernando M. R. et al. Butyrate enhances antibacterial effects while suppressing other features of alternative activation in IL-4-induced macrophages //American Journal of Physiology-Gastrointestinal and Liver Physiology. -2016. -Т. 310. -№.
  17. Forsythe P., Kunze W. A. Voices from within: gut microbes and the CNS //Cellular and molecular life sciences. -2013. -Т. 70. -№. 1. -С. 55-69. doi: 10.1007/s00018- 012-1028-z 100) · DOI
  18. Gaig C., Tolosa E. When does Parkinson's disease begin? //Movement Disorders. - 2009. -Т. 24. -№. S2. -С. 656-664. doi:10.1002/mds.22672 105 · DOI
  19. Goldstein D. S. et al. Cardiac sympathetic denervation in Parkinson disease //Annals of internal medicine. -2000. -Т. 133. -№. 5. -С. 338-347. 109
  20. Hague K. et al. The distribution of Lewy bodies in pure autonomic failure: autopsy findings and review of the literature //Acta neuropathologica. -1997. -Т. 94. -№. 2. - С. 192-196. 115
  21. Hamer H. M. et al. The role of butyrate on colonic function //Alimentary pharmacology & therapeutics. -2008. -Т. 27. -№. 2. -С. 104-119. doi:10.1111/j.1365-2036.2007.03562.x 118 · DOI
  22. D. J., Yu K. Idiot's Bayes-not so stupid after all? //International statistical review. -2001. -Т. 69. -№. 3. -С. 385-398. doi: 10.1111/j.1751- 5823.2001.tb00465.x 119 · DOI
  23. Hawkes C. H., Del Tredici K., Braak H. A timeline for Parkinson's disease //Parkinsonism & related disorders. -2010. -Т. 16. -№. 2. -С. 79-84. doi: 10.1016/j.parkreldis.2009.08.007. 123 · DOI
  24. Heckman M. G. et al. Parkinson's disease susceptibility variants and severity of Lewy body pathology //Parkinsonism & related disorders. -2017. -Т. 44. -С. 79-84. doi: 10.1016/j.parkreldis.2017.09.009 124 · DOI
  25. Hegarty S. V., Sullivan A. M., O'Keeffe G. W. The Epigenome as a therapeutic target for Parkinson's disease //Neural regeneration research. -2016. -Т. 11. -№. 11. - С. 1735. doi:10.4103/1673-5374.194803. · DOI
  26. Heijtz R. D. et al. Normal gut microbiota modulates brain development and behavior //Proceedings of the National Academy of Sciences. -2011. -Т. 108. -№. 7
  27. Holzer P., Farzi A. Neuropeptides and the microbiota-gut-brain axis //Microbial endocrinology: the microbiota-gut-brain axis in health and disease. -Springer, New York, NY, 2014. -С. 195-219. doi:10.1007/978-1-4939-0897-4_9 133 · DOI
  28. Hotelling H. Analysis of a complex of statistical variables into principal components //Journal of educational psychology. -1933. -Т. 24. -№. 6. -С. 417. 136
  29. Imhann F. et al. Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease //Gut. -2016. -С. Gutjnl- 2016-312135. doi: 10.1136/gutjnl-2016-312135 139 · DOI
  30. Jin H. et al. Histone Hyperacetylation Up-regulates Protein Kinase Cδ in Dopaminergic Neurons to Induce Cell Death RELEVANCE TO EPIGENETIC MECHANISMS OF NEURODEGENERATION IN PARKINSON DISEASE //Journal of Biological Chemistry. -2014. -Т. 289. -№. 50. -С. 34743-34767. doi:10.1074/jbc.M114.576702. 145 · DOI
  31. Jumas-Bilak E., Marchandin H. The phylum synergistetes //The Prokaryotes. - Springer Berlin Heidelberg, 2014. -С. 931-954. ISBN 978-3-642-38954-2. doi: 10.1007/978-3-642-38954-2_384 146 · DOI
  32. Kramer P., Bressan P. Humans as superorganisms: How microbes, viruses, imprinted genes, and other selfish entities shape our behavior //Perspectives on Psychological Science. -2015. -Т. 10. -№. 4. -С. 464-481. doi: 10.1177/1745691615583131. 157 · DOI
  33. Kuhn M. et al. Caret package //Journal of statistical software. -2008. -Т. 28. - №. 5. -С. 1-26. 158
  34. Liu B. et al. Vagotomy and Parkinson disease A Swedish register-based matched- cohort study //Neurology. -2017. -Т. 88. -№. 21. -С. 1996-2002. doi:10.1212/WNL.0000000000003961 175 · DOI
  35. Magliacane S. et al. Causal transfer learning //arXiv preprint arXiv:1707.06422. - 2017. 182 · arXiv
  36. Meuric V. et al. Signature of microbial dysbiosis in periodontitis //Applied and environmental microbiology. -2017. -Т. 83. -№. 14. -С. E00462-17. doi: 10.1128/AEM.00462-17. 190 · DOI
  37. Montiel-Castro A. J. et al. The microbiota-gut-brain axis: neurobehavioral correlates, health and sociality //Frontiers in integrative neuroscience. -2013. -Т. 7. - С. 70. doi: 10.3389/fnint.2013.00070 197 · DOI
  38. Müller D. B. et al. The plant microbiota: systems-level insights and perspectives //annual review of genetics. -2016. -Т. 50. -С. 211-234. doi:10.1146/annurev-genet- 120215-034952 200 · DOI
  39. Murray A. E. et al. Microbiome composition and diversity of the ice-dwelling sea anemone, Edwardsiella andrillae //Integrative and comparative biology. -2016. -Т. 56. -№. 4. -С. 542-555. doi: 10.1093/icb/icw095. 202 · DOI
  40. Nishiyama K. et al. Bifidobacterium bifidum Extracellular Sialidase Enhances 2017. -Т. 8. -№. 5. -С. E00928-17. doi:10.1128/mBio.00928-17 206 · DOI
  41. Parkinson J.An essay on the shaking palsy. 1817. Переиздано в Parkinson J. An essay on the shaking palsy //The Journal of neuropsychiatry and clinical neurosciences. -2002. -Т. 14. -№. 2. -С. 223-236. 210
  42. Rutherford S. T., Bassler B. L. Bacterial quorum sensing: its role in virulence and possibilities for its control //Cold Spring Harbor perspectives in medicine. -2012. -Т. 2. -№. 11. -С. A012427. doi: 10.1101/cshperspect.a012427 234 · DOI
  43. Saedisomeolia A., Ashoori M. Riboflavin in Human Health: A Review of Current Evidences //Advances in food and nutrition research. -Academic Press, 2018. -Т. 83. -С. 57-81. doi: 10.1016/bs.afnr.2017.11.002 235 · DOI
  44. Saint-Georges-Chaumet Y. et al. Targeting microbiota-mitochondria inter-talk: Microbiota control mitochondria metabolism //Cellular and Molecular Biology. -2015. -Т. 61. -№. 4. -С. 121-124. doi : 10.14715/cmb/2015.61.4.20 236 · DOI
  45. Shen C. H. et al. Association between tuberculosis and Parkinson disease: a nationwide, population-based cohort study //Medicine. -2016. -Т. 95. -№. 8. doi:10.1097/MD.0000000000002883. 250 · DOI
  46. Stiemsma L. T. et al. The hygiene hypothesis: current perspectives and future therapies //ImmunoTargets and therapy. -2015. -Т. 4. -С. 143. doi: 10.2147/ITT.S61528 260) · DOI
  47. Stilling R. M. et al. Friends with social benefits: host-microbe interactions as a driver of brain evolution and development? //Frontiers in cellular and infection microbiology. -2014. -Т. 4. -С. 147. doi: 10.3389/fcimb.2014.00147 261 · DOI
  48. Sullivan A. et al. The microbiome and the pathophysiology of asthma //Respiratory research. -2016. -Т. 17. -№. 1. -С. 163. doi: 10.1186/s12931-016- 0479-4 264 · DOI
  49. N. S. Regulatory peptides of the gut and brain //Canadian Journal of Surgery. -1983. -Т. 26. -№. 3. -С. 211-3, 228. 270
  50. Velázquez O. C., Lederer H. M., Rombeau J. L. Butyrate and the colonocyte //Dietary fiber in health and disease. -Springer, Boston, MA, 1997. -С. 123-134. 280
  51. Villanueva R. Neurobiology of major depressive disorder //Neural plasticity. - 2013. -Т. 2013. doi: 10.1155/2013/873278 281 · DOI
  52. Visanji N. P. et al. The prion hypothesis in Parkinson's disease: Braak to the future //Acta neuropathologica communications. -2013. -Т. 1. -№. 1. -С. 2. doi:10.1186/2051-5960-1-2 282 · DOI
  53. Wang W. et al. Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein //Proceedings of the National Academy of Sciences. -2016. -Т. 113. -№. 34
  54. Wirdefeldt K. et al. Epidemiology and etiology of Parkinson's disease: a review of the evidence //European journal of epidemiology. -2011. -Т. 26. -№. 1. -С. 1. doi:10.1007/s10654-011-9581-6 295 · DOI
  55. Yozgat Y. et al. Sphingomonas paucimobilis bacteraemia and shock in a patient with rheumatic carditis //Indian journal of medical microbiology. -2014. -Т. 32. -№.
  56. Yu G. et al. Molecular characterization of the human stomach microbiota in gastric cancer patients //Frontiers in cellular and infection microbiology. -2017. -Т. 7. -С. 302. doi: 10.3389/fcimb.2017.00302 301 · DOI

Authors
Petrov, V. A., Saltykova, I. V., Zhukova, I. A., Alifirova, V. M., Zhukova, N. G., Dorofeeva, Y. B., Tyakht, A. V., Kovarsky, B. A., Alekseev, D. G., Kostryukova, E. S., Mironova, Y. S., Izhboldina, O. P., Nikitina, M. A., Perevozchikova, T. V., Fait, E. A., Babenko, V. V., Vakhitova, M. T., Govorun, V. M., & Sazonov, A. E.
Affiliations
  • Siberian State Medical University (RU)
  • Federal Medical-Biological Agency (RU)
  • Institute of Bioorganic Chemistry (RU)
ORCID
Venue
Bulletin of Experimental Biology and Medicine
Publisher
Springer Science and Business Media LLC
Published
2017-04
Volume
162
Issue
6
Pages
734-737
ISSN
  • 0007-4888 (ISSN-L)
  • 1573-8221
DOI
10.1007/s10517-017-3700-7
OpenAlex
W2607019262
Cited by
487
References
14
Citations by year
2026: 23 · 2025: 40 · 2024: 50 · 2023: 58 · 2022: 79 · 2021: 88 · 2020: 65 · 2019: 50 · 2018: 29 · 2017: 4 · 2016: 1
FWCI
16.53
Type
journal article
Language
en
Open access
Licence
Locations
  • Bulletin of Experimental Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
  • ORBi (University of Liège) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
Parkinson's disease, gut microbiota, gut-brain axis, alpha-synuclein aggregation, Lewy bodies, inflammation, 16S rRNA gene sequencing, bacterial genera, Lactobacillus, Oscillospira, Bacteroides, Prevotella, Ruminococcus
MeSH terms
Gastrointestinal Microbiome, Aged, DNA, Bacterial, Feces, Female, Gram-Negative Bacteria, Gram-Positive Bacteria, Humans, Male, Middle Aged, Parkinson Disease, Phylogeny, RNA, Ribosomal, 16S, Case-Control Studies, Sequence Analysis, DNA, Biodiversity, DNA Barcoding, Taxonomic

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