The genetics of Parkinson disease

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240 · see citing works

Parkinson disease

Poewe, W., Seppi, K., Tanner, C. M., Halliday, G. M., Brundin, P., Volkmann, J., Schrag, A.-E., & Lang, A. E. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.13 · Cited by 5,415 · see citing works

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227 · see citing works

α-Synuclein Locus Triplication Causes Parkinson's Disease

Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., et al. (2003) · Science · doi:10.1126/science.1090278 · Cited by 4,383 · see citing works

AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836 · see citing works

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>

Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481 · see citing works

Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

Zimprich, A. A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M. J., Lincoln, S., Kachergus, J. M., Hulihan, M., Uitti, R. J., Calne, D. B., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.005 · Cited by 3,024 · see citing works

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C. J., Squitieri, F., Ibáñez, P., Joosse, M., et al. (2003) · Science · doi:10.1126/science.1077209 · Cited by 2,800 · see citing works

The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia

Zarranz, J. J., Alegre, J., Gómez‐Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atarés, B., et al. (2004) · Annals of Neurology · doi:10.1002/ana.10795 · Cited by 2,737 · see citing works

Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease

Paisán‐Ruiz, C., Jain, S., Evans, E. W., Gilks, W. P., Simón, J., van der Brug, M., de Munaín, A. L., Aparicio, S. F., Gil, A. M., Khan, N. L., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.023 · Cited by 2,416 · see citing works

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease

International Parkinson's Disease Genomics Consortium (IPDGC), Nalls, M. A., Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI), 23andMe, GenePD, NeuroGenetics Research Consortium (NGRC), Hussman Institute of Human Genomics (HIHG), Investigator, T. A. J. D., (CHARGE), C. F. H. A. A. R. I. G. E., North American Brain Expression Consortium (NABEC), et al. (2014) · Nature Genetics · doi:10.1038/ng.3043 · Cited by 1,895 · see citing works

The ubiquitin pathway in Parkinson's disease

Leroy, E., Boyer, R., Auburger, G. W. J., Leube, B., Ulm, G., Mezey, É., Harta, G., Brownstein, M., Jonnalagada, S., Chernova, T., et al. (1998) · Nature · doi:10.1038/26652 · Cited by 1,572 · see citing works

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

Healy, D. G., Falchi, M., O’Sullivan, S. S., Bonifati, V., Dürr, A., Bressman, S., Brice, A., Aasly, J. O., Zabetian, C. P., Goldwurm, S., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70117-0 · Cited by 1,523 · see citing works

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

Satake, W., Nakabayashi, Y., Mizuta, I., Hirota, Y., Ito, C., Kubo, M., Kawaguchi, T., Tsunoda, T., Watanabe, M., Takeda, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.485 · Cited by 1,308 · see citing works

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

Ramirez, A., Heimbach, A., Gründemann, J., Stiller, B., Hampshire, D., Cid, L. P., Goebel, I., Mubaidin, A. F., Wriekat, A.-L., Roeper, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1884 · Cited by 1,208 · see citing works

Causal relation between α-synuclein locus duplication as a cause of familial Parkinson's disease

Ibáñez, P., Bonnet, A. M., Débarges, B., Lohmann, E., Tison, F., Agid, Y., Dürr, A., Brice, A., & Pollak, P. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17104-3 · Cited by 1,042 · see citing works

Parkinson's disease: from monogenic forms to genetic susceptibility factors

Lesage, S., & Brice, A. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp012 · Cited by 946 · see citing works

Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons

Goldberg, M. S., Fleming, S. M., Palacino, J. J., Cepeda, C., Lam, H. A., Bhatnagar, A., Meloni, E. G., Wu, N., Ackerson, L. C., Klapstein, G. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308947200 · Cited by 913 · see citing works

A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease

Zimprich, A. A., Benet‐Pagès, A., Struhal, W., Graf, E., Eck, S. H., Offman, M. N., Haubenberger, D., Spielberger, S., Schulte, E. C., Lichtner, P., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.06.008 · Cited by 885 · see citing works

VPS35 Mutations in Parkinson Disease

Vilariño‐Güell, C., Wider, C. W., Ross, O. A., Dächsel, J. C., Kachergus, J. M., Lincoln, S., Soto‐Ortolaza, A. I., Cobb, S. A., Wilhoite, G. J., Bacon, J. A., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.06.001 · Cited by 877 · see citing works

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

Obeso, J. A., Stamelou, M., Goetz, C. G., Poewe, W., Lang, A. E., Weintraub, D., Burn, D., Halliday, G. M., Bezard, E., Przedborski, S., et al. (2017) · Movement Disorders · doi:10.1002/mds.27115 · Cited by 859 · see citing works

Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling

Cremona, O., Paolo, G. D., Wenk, M. R., Lüthi, A., Kim, W. T., Takei, K., DANIELL, L. W., Nemoto, Y., Shears, S. B., Flavell, R. A., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81649-9 · Cited by 836 · see citing works

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

Polymeropoulos, M. H., Higgins, J. J., Golbe, L. I., Johnson, W. G., Ide, S. E., Di Iorio, G., Sanges, G., Stenroos, E. S., Pho, L. T., Schaffer, A. A., et al. (1996) · Science · doi:10.1126/science.274.5290.1197 · Cited by 788 · see citing works

G51D α‐synuclein mutation causes a novel Parkinsonian–pyramidal syndrome

Lesage, S., Anheim, M., Letournel, F., Bousset, L., Honoré, A., Rozas, N., Pieri, L., Madiona, K., Dürr, A., Melki, R., et al. (2013) · Annals of Neurology · doi:10.1002/ana.23894 · Cited by 697 · see citing works

Alpha‐synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

Appel‐Cresswell, S., Vilariño‐Güell, C., Encarnacion, M. J., Sherman, H. E., Yu, I. S., Shah, B., Weir, D. M., Thompson, C., Szu‐Tu, C., Trinh, J., et al. (2013) · Movement Disorders · doi:10.1002/mds.25421 · Cited by 669 · see citing works

A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2–q13.1

Funayama, M., Hasegawa, K., Kowa, H., Saito, M., Tsuji, S., & Obata, F. (2002) · Annals of Neurology · doi:10.1002/ana.10113 · Cited by 666 · see citing works

What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease

Corti, O., Lesage, S., & Brice, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00022.2010 · Cited by 610 · see citing works

The link between the GBA gene and parkinsonism

Sidransky, E., & Lopez, G. J. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70190-4 · Cited by 586 · see citing works

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

Strauss, K. M., Martins, L. M., Plun‐Favreau, H., Marx, F. P., Kautzmann, S., Berg, D., Gasser, T., Wszolek, Z., Müller, T. H., Bornemann, A., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi215 · Cited by 569 · see citing works

A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

Pasanen, P., Myllykangas, L., Siitonen, M., Raunio, A., Kaakkola, S., Lyytinen, J., Tienari, P. J., Pöyhönen, M., & Paetau, A. E. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.024 · Cited by 535 · see citing works

α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

Gitler, A. D., Chesi, A., Geddie, M. L., Strathearn, K. E., Hamamichi, S., Hill, K. J., Caldwell, K. A., Caldwell, G. A., Cooper, A. A., Rochet, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.300 · Cited by 535 · see citing works

PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron

Morgan, N. V., Westaway, S. K., Morton, J. E. V., Gregory, A., Gissen, P., Sonek, S., Cangül, H., Coryell, J. C., Canham, N. L. E., Nardocci, N., et al. (2006) · Nature Genetics · doi:10.1038/ng1826 · Cited by 532 · see citing works

Parkinson Disease Subtypes

Thenganatt, M. A., & Jankovic, J. J. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.6233 · Cited by 510 · see citing works

Collaborative Analysis of α-Synuclein Gene Promoter Variability and Parkinson Disease

Maraganore, D. M. (2006) · JAMA · doi:10.1001/jama.296.6.661 · Cited by 508 · see citing works

Localization of a Novel Locus for Autosomal Recessive Early-Onset Parkinsonism, PARK6, on Human Chromosome 1p35-p36

Valente, E. M., Bentivoglio, A. R., Dixon, P. H., Ferraris, A., Ialongo, T., Frontali, M., Albanese, A., & Wood, N. W. (2001) · The American Journal of Human Genetics · doi:10.1086/319522 · Cited by 493 · see citing works

Characterization of PLA2G6 as a locus for dystonia‐parkinsonism

Paisán‐Ruiz, C., Bhatia, K. P., Li, A., Hernandez, D. G., Davis, M. B., Wood, N. W., Hardy, J., Houlden, H., Singleton, A., & Schneider, S. A. (2008) · Annals of Neurology · doi:10.1002/ana.21415 · Cited by 479 · see citing works

A novel α-synuclein missense mutation in Parkinson disease

Proukakis, C., Dudzik, C. G., Brier, T., Mackay, D. S., Cooper, J. A. D., Millhauser, G. L., Houlden, H., & Schapira, A. H. V. (2013) · Neurology · doi:10.1212/wnl.0b013e31828727ba · Cited by 465 · see citing works

A susceptibility locus for Parkinson's disease maps to chromosome 2p13

Gasser, T., Müller‐Myhsok, B., Wszołek, Z. K., Oehlmann, R., Calne, D. B., Bonifati, V., Bereznai, B., Fabrizio, E., Vieregge, P., & Horstmann, R. D. (1998) · Nature Genetics · doi:10.1038/ng0398-262 · Cited by 456 · see citing works

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?

Kiely, A. P., Asi, Y. T., Kara, E., Limousin, P. D., Ling, H., Lewis, P. A., Proukakis, C., Quinn, N. P., Lees, A. J., Hardy, J., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1096-7 · Cited by 450 · see citing works

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

Lesage, S., Drouet, V., Majounie, E., Deramecourt, V., Jacoupy, M., Nicolas, A., Cormier‐Dequaire, F., Hassoun, S. M., Pujol, C., Ciura, S., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.01.014 · Cited by 438 · see citing works

Survival and dementia in GBA ‐associated Parkinson's disease: T he mutation matters

Cilia, R., Tùnesi, S., Marotta, G., Cereda, E., Siri, C., Tesei, S., Zecchinelli, A., Canesi, M., Mariani, C. B., Meucci, N., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24777 · Cited by 407 · see citing works

Exploring Braak’s hypothesis of Parkinson’s disease

Rietdijk, C. D., Perez-Pardo, P., Garssen, J., van Wezel, R. J. A., & Kraneveld, A. D. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00037 · Cited by 395 · see citing works

Parkinson's disease: Autoimmunity and neuroinflammation

VIRGILIO, A. D., Greco, A., Fabbrini, G., Inghilleri, M., Rizzo, M. I., Gallo, A., Conte, M., Rosato, C., Appiani, M. C., & VINCENTIIS, M. D. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.07.022 · Cited by 391 · see citing works

The role of pathogenic DJ‐1 mutations in Parkinson's disease

Abou‐Sleiman, P. M., Healy, D. G., Quinn, N. P., Lees, A. J., & Wood, N. W. (2003) · Annals of Neurology · doi:10.1002/ana.10675 · Cited by 381 · see citing works

PARK7, a Novel Locus for Autosomal Recessive Early-Onset Parkinsonism, on Chromosome 1p36

van Duijn, C. M., Dekker, M. C. J., Bonifati, V., Galjaard, R. H., Houwing‐Duistermaat, J. J., Snijders, P. J. L. M., Testers, L., Breedveld, G. J., Horstink, M. W. I. M., Sandkuijl, L. A., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/322996 · Cited by 378 · see citing works

Neuropathological Staging of Brain Pathology in Sporadic Parkinson’s disease: Separating the Wheat from the Chaff

Braak, H., & Del Tredici, K. (2017) · Journal of Parkinson’s Disease · doi:10.3233/jpd-179001 · Cited by 372 · see citing works

Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27.

Matsumine, H., Saito, M., Shimoda‐Matsubayashi, S., Tanaka, H., Ishikawa, A., Nakagawa-Hattori, Y., Yokochi, M., Kobayashi, T., Igarashi, S., Takano, H., et al. (1997) · Europe PMC (PubMed Central) · Cited by 371 · see citing works

Differential effects of severe vs mild GBA mutations on Parkinson disease

Gan‐Or, Z., Amshalom, I., Kilarski, L. L., Bar‐Shira, A., Gana‐Weisz, M., Mirelman, A., Marder, K. S., Bressman, S., Giladi, N., & Orr‐Urtreger, A. (2015) · Neurology · doi:10.1212/wnl.0000000000001315 · Cited by 366 · see citing works

FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome

Fonzo, A. D., Dekker, M. C. J., Montagna, P., Baruzzi, A., Yonova, E. H., Guedes, L. C., Szczerbińska, A., Zhao, T., Dubbel, L., Wouters, C. H., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000338144.10967.2b · Cited by 363 · see citing works

CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study

Funayama, M., Ohe, K., Amo, T., Furuya, N., Yamaguchi, J., Saiki, S., Li, Y., Ogaki, K., Ando, M., Yoshino, H., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70266-2 · Cited by 351 · see citing works

The Sac1 Domain of SYNJ 1 Identified Mutated in a Family with Early‐Onset Progressive P arkinsonism with Generalized Seizures

Krebs, C. E., Karkheiran, S., Powell, J., Cao, M., Makarov, V., Darvish, H., Paolo, G. D., Walker, R. H., Shahidi, G. A., Buxbaum, J. D., et al. (2013) · Human Mutation · doi:10.1002/humu.22372 · Cited by 336 · see citing works

Mutation in theSYNJ1Gene Associated with Autosomal Recessive, Early-Onset Parkinsonism

Quadri, M., Fang, M., Picillo, M., Olgiati, S., Breedveld, G. J., Graafland, J., Wu, B., Xu, F., Erro, R., Amboni, M., et al. (2013) · Human Mutation · doi:10.1002/humu.22373 · Cited by 320 · see citing works

A Deleterious Mutation in DNAJC6 Encoding the Neuronal-Specific Clathrin-Uncoating Co-Chaperone Auxilin, Is Associated with Juvenile Parkinsonism

Edvardson, S., Cinnamon, Y., Ta‐Shma, A., Shaag, A., Yim, Y.-I., Zenvirt, S., Jalas, C., Lesage, S., Brice, A., Taraboulos, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036458 · Cited by 318 · see citing works

DNAJC13 mutations in Parkinson disease

Vilariño‐Güell, C., Rajput, A. H., Milnerwood, A. J., Shah, B., Szu‐Tu, C., Trinh, J., Yu, I. S., Encarnacion, M. J., Munsie, L. N., Tapia, L., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt570 · Cited by 313 · see citing works

Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease

Chartier‐Harlin, M., Dächsel, J. C., Vilariño‐Güell, C., Lincoln, S., Leprêtre, F., Hulihan, M., Kachergus, J. M., Milnerwood, A. J., Tapia, L., Song, M.-S., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.08.009 · Cited by 298 · see citing works

The genetic background of Parkinson's disease: current progress and future prospects

Kalinderi, K., Bostantjopoulou, S., & Fidani, L. (2016) · Acta Neurologica Scandinavica · doi:10.1111/ane.12563 · Cited by 280 · see citing works

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

Gray, C. W., Ward, R. V., Karran, E. H., Turconi, S., Rowles, A., Viglienghi, D., Southan, C., BARTON, A. J. L., Fantom, K. G. M., West, A., et al. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01589.x · Cited by 278 · see citing works

A susceptibility gene for late‐onset idiopathic Parkinson's disease

Hicks, A. A., Pétursson, H., Jónsson, T., Stefánsson, H., Johannsdottir, H., Sainz, J., Frigge, M. L., Kong, A., Gulcher, J. R., Stefánsson, K., et al. (2002) · Annals of Neurology · doi:10.1002/ana.10324 · Cited by 260 · see citing works

Genome-wide Linkage Analysis of a Parkinsonian-Pyramidal Syndrome Pedigree by 500 K SNP Arrays

Shojaee, S., Sina, F., Banihosseini, S. S., Kazemi, M., Kalhor, R., Shahidi, G. A., Fakhrai-Rad, H., Ronaghi, M., & Elahi, E. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.05.005 · Cited by 257 · see citing works

Parkin structure and function

Seirafi, M., Kozlov, G., & Gehring, K. (2015) · The FEBS Journal · doi:10.1111/febs.13249 · Cited by 256 · see citing works

A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor

Farrer, M. J. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.1.81 · Cited by 249 · see citing works

Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression

Henry, A. G., Aghamohammadzadeh, S., Samaroo, H., Chen, Y., Mou, K., Needle, E., & Hirst, W. D. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv314 · Cited by 235 · see citing works

Comparison of Parkinson Risk in Ashkenazi Jewish Patients With Gaucher Disease andGBAHeterozygotes

Alcalay, R. N., Dinur, T., Quinn, T., Sakanaka, K., Levy, O., Waters, C., Fahn, S., Dorovski, T., Chung, W. K., Pauciulo, M. W., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.313 · Cited by 216 · see citing works

Autosomal dominant Parkinson's disease caused by SNCA duplications

Konno, T., Ross, O. A., Puschmann, A., Dickson, D. W., & Wszołek, Z. K. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.09.007 · Cited by 210 · see citing works

Loss ofPLA2G6leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction

Kinghorn, K. J., Castillo-Quan, J. I., Bartolomé, F. B., Angelova, P. R., Li, L., Pope, S. A. S., Cochemé, H. M., Khan, S., Asghari, S., Bhatia, K. P., et al. (2015) · Brain · doi:10.1093/brain/awv132 · Cited by 197 · see citing works

D NAJC 6 M utations A ssociated W ith E arly‐ O nset P arkinson's D isease

Olgiati, S., Quadri, M., Fang, M., Rood, J. P. M. A., Saute, J. A. M., Chien, H. F., Bouwkamp, C. G., Graafland, J., Minneboo, M., Breedveld, G. J., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24553 · Cited by 197 · see citing works

DNAJC6 is responsible for juvenile parkinsonism with phenotypic variability

Köroğlu, Ç., Baysal-Kıraç, L., Çetinkaya, M., Karasoy, H., & Tolun, A. (2012) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2012.11.006 · Cited by 190 · see citing works

Mutations in the GIGYF2 (TNRC15) Gene at the PARK11 Locus in Familial Parkinson Disease

Lautier, C., Goldwurm, S., Dürr, A., Giovannone, B., Tsiaras, W. G., Pezzoli, G., Brice, A., & Smith, R. J. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.015 · Cited by 177 · see citing works

Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein

Dhungel, N., Eleuteri, S., Li, L.-B., Kramer, N. J., Chartron, J. W., Spencer, B. J., Kosberg, K. A., Fields, J. A., Stafa, K., Adame, A., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.11.027 · Cited by 176 · see citing works

Identification of TMEM230 mutations in familial Parkinson's disease

Deng, H., Shi, Y., Yang, Y., Ahmeti, K., Miller, N., Huang, C., Cheng, L., Zhai, H., Deng, S., Nuytemans, K., et al. (2016) · Nature Genetics · doi:10.1038/ng.3589 · Cited by 171 · see citing works

LRRK2 pathobiology in Parkinson's disease

Martin, I., Kim, J. W., Dawson, V. L., & Dawson, T. M. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12949 · Cited by 168 · see citing works

An updated review of Parkinson's disease genetics and clinicopathological correlations

Ferreira, M., & Massano, J. (2017) · Acta Neurologica Scandinavica · doi:10.1111/ane.12616 · Cited by 167 · see citing works

Significant Linkage of Parkinson Disease to Chromosome 2q36-37

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α-Synuclein-Based Animal Models of Parkinson's Disease: Challenges and Opportunities in a New Era

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