Effects of Tripeptide Gly-His-Lys in Pain-Induced Aggressive-Defensive Behavior in Rats
Abstract
We studied the effect of Gly-His -Lys tripeptide administered intraperitoneally in doses of 5, 15, 50 and 150 μg/kg on pain-induced aggressive-defensive behavior. A foot-shock model of aggression in rats grouped in pairs in an electrified chamber was used. Analgesic and antiaggresiogenic effects of the peptide were demonstrated. It was found the L-lysine residue plays the key role in these effects, because they were observed under the influence of L-lysine administration in doses close to its equimolar content in the studied tripeptide.
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In rats, attacks were reduced 5-fold when rats were placed into an aggression-stimulating environment 12 minutes after injection of 0.5 micrograms GHK per kilogram of body weight.
“The attacks were reduced 5-fold, when rats were placed into an agression-stimulating environment 12 min after the injection of 0.5 micrograms GHK per kilogram of body weight.”
From Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data (2018) · cites this paper as [55]
If scaled up for human weight, the rat anti-aggression result suggests that a similar effect might be induced in humans by 35 micrograms of GHK, a very low and safe dosage.
“If scaled up for human weight, this suggests that a similar effect might be induced in humans by 35 micrograms of GHK, which is a very low and safe dosage [55].”
From Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data (2018) · cites this paper as [55]
Cites
The human tri-peptide GHK and tissue remodeling
Pickart, L. (2008) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/156856208784909435 · Cited by 218 · see citing works
Pagani, J. H., Zhao, M., Cui, Z., Williams Avram, S. K., Caruana, D. A., Dudek, S. M., & Young, W. S. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.47 · Cited by 204 · see citing works
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Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data
Pickart, L., & Margolina, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071987 · Cited by 158 · see citing works
- Authors
- Sever’yanova, L. А., & Dolgintsev, M. E.
- Venue
- Bulletin of Experimental Biology and Medicine
- Published
- 2017-11-27
- Volume
- 164
- Issue
- 2
- Pages
- 140-143
- ISSN
- 0007-4888 (ISSN-L)
- 1573-8221
- OpenAlex
- W2768836879
- Cited by
- 5
- References
- 2
- Citations by year
- 2022: 1 · 2019: 1 · 2018: 3
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bulletin of Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- analgesic effect, antiaggressive effects, L-lysine, intraperitoneal administration
- MeSH terms
- Aggression, Analgesics, Animals, Electroshock, Lysine, Male, Oligopeptides, Pain, Tranquilizing Agents, Rats, Wistar, Rats
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