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Cited by 106Hormonal and reproductive studiesNutrition and Health in AgingMuscle Physiology and Disorders

The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.

Sex hormones and skeletal muscle weakness

Open access
Sipilä, Sarianna, Narici, Marco, Kjaer, Michael, Pöllänen, Eija, Atkinson, Ross A., Hansen, Mette, Kovanen, Vuokko·2013·Biogerontology
DOI 10.1007/s10522-013-9425-8
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Abstract

Human ageing is accompanied with deterioration in endocrine functions the most notable and well characterized of which being the decrease in the production of sex hormones. Current research literature suggests that low sex hormone concentration may be among the key mechanism for sarcopenia and muscle weakness. Within the European large scale MYOAGE project, the role of sex hormones, estrogens and testosterone, in causing the aging-related loss of muscle mass and function was further investigated. Hormone replacement therapy (HRT) in women is shown to diminish age-associated muscle loss, loss in fast muscle function (power), and accumulation of fat in skeletal muscle. Further HRT raises the protein synthesis rate in skeletal muscle after resistance training, and has an anabolic effect upon connective tissue in both skeletal muscle and tendon, which influences matrix structure and mechanical properties. HRT influences gene expression in e.g. cytoskeletal and cell-matrix proteins, has a stimulating effect upon IGF-I, and a role in IL-6 and adipokine regulation. Despite low circulating steroid-hormone level, postmenopausal women have a high local concentration of steroidogenic enzymes in skeletal muscle.

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Metadata

Authors
Sipilä, S., Narici, M., Kjaer, M., Pöllänen, E., Atkinson, R. A., Hansen, M., & Kovanen, V.
Affiliations
  • University of Jyväskylä (FI)
  • University of Nottingham (GB)
  • Manchester Academic Health Science Centre (GB)
  • Aarhus University (DK)
Corresponding author
Sipilä, Sarianna
ORCID
Venue
Biogerontology
Publisher
Springer Science and Business Media LLC
Published
2013-05-01
Volume
14
Issue
3
Pages
231-245
ISSN
  • 1389-5729 (ISSN-L)
  • 1573-6768
DOI
10.1007/s10522-013-9425-8
OpenAlex
W2168506543
Cited by
106
References
81
Citations by year
2026: 7 · 2025: 13 · 2024: 8 · 2023: 11 · 2022: 10 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 11 · 2017: 7 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 2
FWCI
0.88
Type
journal article
Language
en
Open access
Licence
Locations
  • Biogerontology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Funders
  • Academy of Finland
  • Medical Research Council (MR/K00414X/1)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
sex hormones, skeletal muscle weakness, sarcopenia, aging, hormone replacement therapy, estrogen, testosterone, postmenopausal women, muscle mass loss, resistance training, insulin-like growth factor I, adipokines, interleukin-6, tendons, connective tissue, steroidogenic enzymes
MeSH terms
Aging, Estrogens, Female, Humans, Male, Gonadal Steroid Hormones, Testosterone, Muscle, Skeletal, Muscle Weakness, Hormone Replacement Therapy

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