Plant extracts and natural compounds used against UVB-induced photoaging
Open accessAbstract
Skin is continuously exposed to a variety of environmental stresses, including ultraviolet (UV) radiation. UVB is an inherent component of sunlight that crosses the epidermis and reaches the upper dermis, leading to increased oxidative stress, activation of inflammatory response and accumulation of DNA damage among other effects. The increase in UVB radiation on earth due to the destruction of stratospheric ozone poses a major environmental threat to the skin, increasing the risk of damage with long-term consequences, such as photoaging and photocarcinogenesis. Extracts from plants and natural compounds have been historically used in traditional medicine in the form of teas and ointments but the effect of most of these compounds has yet to be verified. Regarding the increasing concern of the population with issues related to quality of life and appearance, the cosmetic market for anti-aging and photoprotective products based on natural compounds is continuously growing, and there is increasing requirement of expansion on research in this field. In this review we summarized the most current and relevant information concerning plant extracts and natural compounds that are able to protect or mitigate the deleterious effects caused by photoaging in different experimental models.
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Natural compounds used against photoaging comprise phenolic compounds including flavonoids, phenolic acids, and stilbenes derived from plants such as tea, grape, bergamot, fernblock, rooibos, grapefruit, and red orange.
“Natural compounds used against photoaging comprise phenolic compounds, including flavonoids (catechins, isoflavones, proanthocyanidins, and anthocyanins), phenolic acids (benzoic, gallic, and cinnamic acids), and stilbenes derived from plants such as tea, grape, bergamot, fernblock, rooibos, grapefruit, and red orange [4, 88, 90].”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [88]
Phenolic compounds, ascorbic acid, and carotenoids derived from different plant species are able to protect the skin by preventing UV penetration, reducing inflammation and oxidative stress, and influencing several survival signalling pathways.
“Phenolic compounds, ascorbic acid and carotenoids, derived from different plant species, are able to protect the skin by preventing UV penetration, reducing inflammation and oxidative stress, and influencing several survival signalling pathways.”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [88]
Capsanthin and capsorubin from red pepper fruits have protective properties against UVB-induced DNA damage in human dermal fibroblasts.
“Carotenoids capsanthin and capsorubin from red pepper (Capsicum annuum L.) fruits have also been found to have protective properties against UVB-induced DNA damage in human dermal fibroblasts [88, 108].”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [88]
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References 59 · Cited by 218
- Authors
- Cavinato, M., Waltenberger, B., Baraldo, G., Grade, C. V. C., Stuppner, H., & Jansen-Dürr, P.
- Affiliations
- Universität Innsbruck (AT)
- Universidade Federal da Integração Latino-Americana (BR)
- Corresponding author
- Cavinato, Maria
- Venue
- Biogerontology
- Published
- 2017-07-12
- Volume
- 18
- Issue
- 4
- Pages
- 499-516
- ISSN
- 1389-5729 (ISSN-L)
- 1573-6768
- PMC
- PMC5514221
- OpenAlex
- W2734749797
- Cited by
- 218
- References
- 59
- Citations by year
- 2026: 10 · 2025: 20 · 2024: 24 · 2023: 37 · 2022: 38 · 2021: 23 · 2020: 35 · 2019: 21 · 2018: 8 · 2017: 2
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Biogerontology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Library of the University of Innsbruck (University of Innsbruck) (submittedVersion, cc-by)
- Funders
- CNPq (201892/2012-0)
- Österreichische Forschungsförderungsgesellschaft (FP7 FRAILOMIC, 848474)
- Austrian and Tyrolean Science Funds (FWF P-28039)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- UV-B radiation, photoaging, plant extracts, natural compounds, photoprotection, anti-aging cosmetics, oxidative stress, DNA damage, inflammation, photocarcinogenesis, stratospheric ozone depletion, traditional medicine
- MeSH terms
- Animals, Biological Products, Cosmetics, Humans, Plant Extracts, Skin, Sunlight, Ultraviolet Rays, Signal Transduction, Skin Aging, Risk Assessment, Models, Animal
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