Integrated wireless neural interface based on the Utah electrode array
Abstract
This report presents results from research towards a fully integrated, wireless neural interface consisting of a 100-channel microelectrode array, a custom-designed signal processing and telemetry IC, an inductive power receiving coil, and SMD capacitors. An integration concept for such a device was developed, and the materials and methods used to implement this concept were investigated. We developed a multi-level hybrid assembly process that used the Utah Electrode Array (UEA) as a circuit board. The signal processing IC was flip-chip bonded to the UEA using Au/Sn reflow soldering, and included amplifiers for up to 100 channels, signal processing units, an RF transmitter, and a power receiving and clock recovery module. An under bump metallization (UBM) using potentially biocompatible materials was developed and optimized, which consisted of a sputter deposited Ti/Pt/Au thin film stack with layer thicknesses of 50/150/150 nm, respectively. After flip-chip bonding, an underfiller was applied between the IC and the UEA to improve mechanical stability and prevent fluid ingress in in vivo conditions. A planar power receiving coil fabricated by patterning electroplated gold films on polyimide substrates was connected to the IC by using a custom metallized ceramic spacer and SnCu reflow soldering. The SnCu soldering was also used to assemble SMD capacitors on the UEA. The mechanical properties and stability of the optimized interconnections between the UEA and the IC and SMD components were measured. Measurements included the tape tests to evaluate UBM adhesion, shear testing between the Au/Sn solder bumps and the substrate, and accelerated lifetime testing of the long-term stability for the underfiller material coated with a a-SiC(x):H by PECVD, which was intended as a device encapsulation layer. The materials and processes used to generate the integrated neural interface device were found to yield a robust and reliable integrated package.
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Wireless versions of the UEA and other systems have been developed, but these prototype systems are not yet sufficiently robust for clinical use.
“A clinical cortical visual prosthesis would be expected to use wireless actuation of the electrode arrays, and although wireless versions of the UEA and other systems have been developed (31, 50, 51), these prototype systems are not yet sufficiently robust for clinical use.”
From Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex (2021) · cites this paper as [50]
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References 47 · Cited by 165
- Authors
- Kim, S., Bhandari, R., Klein, M., Negi, S., Rieth, L., Tathireddy, P., Toepper, M., Oppermann, H., & Solzbacher, F.
- Affiliations
- University of Utah (US)
- Fraunhofer Institute for Reliability and Microintegration (DE)
- Corresponding author
- Kim, S.
- Venue
- Biomedical Microdevices
- Published
- 2008-12-10
- Volume
- 11
- Issue
- 2
- Pages
- 453-466
- ISSN
- 1387-2176 (ISSN-L)
- 1572-8781
- OpenAlex
- W1991326578
- Cited by
- 165
- References
- 47
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 11 · 2019: 5 · 2018: 8 · 2017: 12 · 2016: 12 · 2015: 9 · 2014: 19 · 2013: 20 · 2012: 6
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biomedical Microdevices (publishedVersion)
- PubMed (publishedVersion)
- Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- Funders
- National Institutes of Health
- Defense Advanced Research Projects Agency
- U.S. Public Health Service (HHSN265200423621C)
- National Institute of Neurological Disorders and Stroke
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electronic Packaging and Soldering Technologies
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Keywords
- wireless neural interface, Utah electrode array, microelectrode arrays, flip-chip bonding, under bump metallization, underfill, electroplated gold, polyimide substrate, tape test, shear testing, accelerated life testing, biomaterials
- MeSH terms
- Electrodes, Implanted, Electrophysiology, Equipment Design, Microelectrodes, Sensitivity and Specificity, Signal Processing, Computer-Assisted, Telemetry, Reproducibility of Results, Systems Integration, Equipment Failure Analysis
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