Cited by 165Neuroscience and Neural EngineeringElectronic Packaging and Soldering TechnologiesAnalog and Mixed-Signal Circuit Design

Integrated wireless neural interface based on the Utah electrode array

Kim, S., Bhandari, R., Klein, M., Negi, S., Rieth, L., Tathireddy, P., Toepper, M., Oppermann, H. +1 more·2009·Biomedical Microdevices

Abstract

This report presents results from research towards a fully integrated, wireless neural interface consisting of a 100-channel microelectrode array, a custom-designed signal processing and telemetry IC, an inductive power receiving coil, and SMD capacitors. An integration concept for such a device was developed, and the materials and methods used to implement this concept were investigated. We developed a multi-level hybrid assembly process that used the Utah Electrode Array (UEA) as a circuit board. The signal processing IC was flip-chip bonded to the UEA using Au/Sn reflow soldering, and included amplifiers for up to 100 channels, signal processing units, an RF transmitter, and a power receiving and clock recovery module. An under bump metallization (UBM) using potentially biocompatible materials was developed and optimized, which consisted of a sputter deposited Ti/Pt/Au thin film stack with layer thicknesses of 50/150/150 nm, respectively. After flip-chip bonding, an underfiller was applied between the IC and the UEA to improve mechanical stability and prevent fluid ingress in in vivo conditions. A planar power receiving coil fabricated by patterning electroplated gold films on polyimide substrates was connected to the IC by using a custom metallized ceramic spacer and SnCu reflow soldering. The SnCu soldering was also used to assemble SMD capacitors on the UEA. The mechanical properties and stability of the optimized interconnections between the UEA and the IC and SMD components were measured. Measurements included the tape tests to evaluate UBM adhesion, shear testing between the Au/Sn solder bumps and the substrate, and accelerated lifetime testing of the long-term stability for the underfiller material coated with a a-SiC(x):H by PECVD, which was intended as a device encapsulation layer. The materials and processes used to generate the integrated neural interface device were found to yield a robust and reliable integrated package.

Integrity signals

Registry

Crossref · 10.1007/s10544-008-9251-y

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Wireless versions of the UEA and other systems have been developed, but these prototype systems are not yet sufficiently robust for clinical use.

    “A clinical cortical visual prosthesis would be expected to use wireless actuation of the electrode arrays, and although wireless versions of the UEA and other systems have been developed (31, 50, 51), these prototype systems are not yet sufficiently robust for clinical use.”

The citation lists haven’t been fetched yet

References 47 · Cited by 165

Authors
Kim, S., Bhandari, R., Klein, M., Negi, S., Rieth, L., Tathireddy, P., Toepper, M., Oppermann, H., & Solzbacher, F.
Affiliations
  • University of Utah (US)
  • Fraunhofer Institute for Reliability and Microintegration (DE)
Corresponding author
Kim, S.
Venue
Biomedical Microdevices
Published
2008-12-10
Volume
11
Issue
2
Pages
453-466
ISSN
  • 1387-2176 (ISSN-L)
  • 1572-8781
OpenAlex
W1991326578
Cited by
165
References
47
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 11 · 2019: 5 · 2018: 8 · 2017: 12 · 2016: 12 · 2015: 9 · 2014: 19 · 2013: 20 · 2012: 6
FWCI
4.61
Type
journal article
Language
en
Open access
closed
Locations
  • Biomedical Microdevices (publishedVersion)
  • PubMed (publishedVersion)
  • Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion)
  • Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
Funders
  • National Institutes of Health
  • Defense Advanced Research Projects Agency
  • U.S. Public Health Service (HHSN265200423621C)
  • National Institute of Neurological Disorders and Stroke
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electronic Packaging and Soldering Technologies
  • Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
Keywords
wireless neural interface, Utah electrode array, microelectrode arrays, flip-chip bonding, under bump metallization, underfill, electroplated gold, polyimide substrate, tape test, shear testing, accelerated life testing, biomaterials
MeSH terms
Electrodes, Implanted, Electrophysiology, Equipment Design, Microelectrodes, Sensitivity and Specificity, Signal Processing, Computer-Assisted, Telemetry, Reproducibility of Results, Systems Integration, Equipment Failure Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review